Long-term causes of death in patients with infective endocarditis who undergo medical therapy only or surgical treatment: A nationwide population-based study
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Long-term causes of death in patients with infective endocarditis who undergo medical therapy only or surgical treatment : A nationwide population-based study. / Østergaard, Lauge; Oestergaard, Louise Bruun; Lauridsen, Trine Kiilerich; Dahl, Anders; Chaudry, Mavish; Gislason, Gunnar; Torp-Pedersen, Christian; Bruun, Niels Eske; Valeur, Nana; Køber, Lars; Fosbøl, Emil Loldrup.
I: European Journal of Cardio-Thoracic Surgery, Bind 54, Nr. 5, 2018, s. 860-866.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Long-term causes of death in patients with infective endocarditis who undergo medical therapy only or surgical treatment
T2 - A nationwide population-based study
AU - Østergaard, Lauge
AU - Oestergaard, Louise Bruun
AU - Lauridsen, Trine Kiilerich
AU - Dahl, Anders
AU - Chaudry, Mavish
AU - Gislason, Gunnar
AU - Torp-Pedersen, Christian
AU - Bruun, Niels Eske
AU - Valeur, Nana
AU - Køber, Lars
AU - Fosbøl, Emil Loldrup
PY - 2018
Y1 - 2018
N2 - OBJECTIVES: It is known that patients surviving infective endocarditis have a poor long-term prognosis; however, few studies have addressed the long-term causes of death in patients surviving the initial hospitalization. METHODS: Using Danish administrative registries, we identified patients admitted to a hospital with 1st time infective endocarditis in the period from January 1996 to December 2014, who were alive at the time of discharge. The study population was categorized into (i) patients undergoing medical therapy only and (ii) patients undergoing surgical and medical treatment. We examined the cardiovascular and non-cardiovascular causes of death. Using the Cox analysis, we investigated the associated risk of dying from a specific prespecified cause of death (heart failure, infective endocarditis and stroke) within the surgery group when compared with the medically treated group. RESULTS: We identified 5576 patients: 4220 patients belonged to the medically treated group and 1356 patients to the surgery group. At the 10-year follow-up, the mortality rate was 63.1% and 41.6% in the medically treated group and the surgery group, respectively. Cardiovascular disease was the most frequent cause of death in both groups accounting for 52.5% in the medically treated group and 55.2% in the surgery group. Patients undergoing surgery were associated with a lower risk of dying from heart failure and stroke when compared with medically treated patients [hazard ratio = 0.66 (95% confidence interval: 0.46–0.94) and hazard ratio = 0.59 (95% confidence interval: 0.37–0.96), respectively]. CONCLUSIONS: No major differences were found in the main causes of death between groups. Patients in the surgical group were associated with a lower risk of dying from heart failure and stroke when compared with medically treated patients.
AB - OBJECTIVES: It is known that patients surviving infective endocarditis have a poor long-term prognosis; however, few studies have addressed the long-term causes of death in patients surviving the initial hospitalization. METHODS: Using Danish administrative registries, we identified patients admitted to a hospital with 1st time infective endocarditis in the period from January 1996 to December 2014, who were alive at the time of discharge. The study population was categorized into (i) patients undergoing medical therapy only and (ii) patients undergoing surgical and medical treatment. We examined the cardiovascular and non-cardiovascular causes of death. Using the Cox analysis, we investigated the associated risk of dying from a specific prespecified cause of death (heart failure, infective endocarditis and stroke) within the surgery group when compared with the medically treated group. RESULTS: We identified 5576 patients: 4220 patients belonged to the medically treated group and 1356 patients to the surgery group. At the 10-year follow-up, the mortality rate was 63.1% and 41.6% in the medically treated group and the surgery group, respectively. Cardiovascular disease was the most frequent cause of death in both groups accounting for 52.5% in the medically treated group and 55.2% in the surgery group. Patients undergoing surgery were associated with a lower risk of dying from heart failure and stroke when compared with medically treated patients [hazard ratio = 0.66 (95% confidence interval: 0.46–0.94) and hazard ratio = 0.59 (95% confidence interval: 0.37–0.96), respectively]. CONCLUSIONS: No major differences were found in the main causes of death between groups. Patients in the surgical group were associated with a lower risk of dying from heart failure and stroke when compared with medically treated patients.
KW - Cause of death
KW - Infective endocarditis
KW - Population study
U2 - 10.1093/ejcts/ezy156
DO - 10.1093/ejcts/ezy156
M3 - Journal article
C2 - 29648662
AN - SCOPUS:85053710095
VL - 54
SP - 860
EP - 866
JO - European Journal of Cardio-thoracic Surgery
JF - European Journal of Cardio-thoracic Surgery
SN - 1010-7940
IS - 5
ER -
ID: 218437143