Long-term carriage and evolution of VREfmLong-term carriage and evolution of vancomycin-resistant Enterococcus faecium: A genomic study on consecutive isolates
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Long-term carriage and evolution of VREfmLong-term carriage and evolution of vancomycin-resistant Enterococcus faecium : A genomic study on consecutive isolates. / Knudsen, Maja Johanne Sondergaard; Samaniego Castruita, Jose Alfredo; Mollerup, Sarah; Holzknecht, Barbara Juliane; Hoppe, Morten; Westh, Henrik; Pinholt, Mette; Rubin, Ingrid Maria Cecilia.
I: JAC-Antimicrobial Resistance, Bind 6, Nr. 1, dlad153, 2024.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Long-term carriage and evolution of VREfmLong-term carriage and evolution of vancomycin-resistant Enterococcus faecium
T2 - A genomic study on consecutive isolates
AU - Knudsen, Maja Johanne Sondergaard
AU - Samaniego Castruita, Jose Alfredo
AU - Mollerup, Sarah
AU - Holzknecht, Barbara Juliane
AU - Hoppe, Morten
AU - Westh, Henrik
AU - Pinholt, Mette
AU - Rubin, Ingrid Maria Cecilia
N1 - Publisher Copyright: © 2023 The Author(s). Published by Oxford University Press on behalf of British Society for Antimicrobial Chemotherapy.
PY - 2024
Y1 - 2024
N2 - Objectives: To determine if vancomycin-resistant Enterococcus faecium (VREfm) carriers carry the same VREfm clone after a minimum follow-up of 365days. For those carrying the same clone, we investigated the genomic evolution per year per genome. Methods: We used WGS results to assign VREfm clones to each isolate and determine clone shifts. Finally, we calculated distance in core-genome MLST alleles, and the number of SNPs between consecutive VREfm isolates from patients carrying the same VREfm clone. Results: In total, 44.2% of patients carried the same VREfm clone, and the genomic evolution was 1.8 alleles and 2.6 SNPs per genome per year. Conclusions: In our population of long-term carriers, we calculated a molecular clock of 2.6 SNPs.
AB - Objectives: To determine if vancomycin-resistant Enterococcus faecium (VREfm) carriers carry the same VREfm clone after a minimum follow-up of 365days. For those carrying the same clone, we investigated the genomic evolution per year per genome. Methods: We used WGS results to assign VREfm clones to each isolate and determine clone shifts. Finally, we calculated distance in core-genome MLST alleles, and the number of SNPs between consecutive VREfm isolates from patients carrying the same VREfm clone. Results: In total, 44.2% of patients carried the same VREfm clone, and the genomic evolution was 1.8 alleles and 2.6 SNPs per genome per year. Conclusions: In our population of long-term carriers, we calculated a molecular clock of 2.6 SNPs.
U2 - 10.1093/jacamr/dlad153
DO - 10.1093/jacamr/dlad153
M3 - Journal article
C2 - 38161962
AN - SCOPUS:85183077228
VL - 6
JO - JAC-Antimicrobial Resistance
JF - JAC-Antimicrobial Resistance
SN - 2632-1823
IS - 1
M1 - dlad153
ER -
ID: 381057968