Involvement of lymphocyte function-associated antigen-1 (LFA-1) in HIV infection: inhibition by monoclonal antibody.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning
Monoclonal antibodies (MAbs) against the alpha- and beta-chain of lymphocyte-associated antigen-1 (LFA-1) were examined for inhibition of HIV-1 infection in vitro. Infection of the T cell line MT4 and the monocytic cell line U937 by isolates HTLVIIIB and SSI-002, respectively was inhibited in a concentration dependent manner by MAb against the beta-chain but not against the alpha-chain. No cross-reactivity was found between MAb against LFA-1 and against the CD4 receptor (MAb Leu3a). MAbs against the beta-chain and the CD4 receptor were found to act synergistically in inhibiting HIV infection. These data indicate that the beta-chain of LFA-1 in addition to the CD4 receptor may be involved in HIV infection in vitro.
Bidragets oversatte titel | Involvement of lymphocyte function-associated antigen-1 (LFA-1) in HIV infection: inhibition by monoclonal antibody. |
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Originalsprog | Engelsk |
Tidsskrift | Scandinavian Journal of Infectious Diseases |
Vol/bind | 23 |
Udgave nummer | 1 |
Sider (fra-til) | 31-36 |
Antal sider | 6 |
ISSN | 0036-5548 |
Status | Udgivet - 1991 |
ID: 34124771