Inhibition of sodium-proton-exchanger subtype 3-mediated sodium absorption in the gut: A new antihypertensive concept
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
Standard
Inhibition of sodium-proton-exchanger subtype 3-mediated sodium absorption in the gut : A new antihypertensive concept. / Linz, Benedikt; Saljic, Arnela; Hohl, Mathias; Gawalko, Monika; Jespersen, Thomas; Sanders, Prashanthan; Bohm, Michael; Linz, Dominik.
I: IJC Heart and Vasculature, Bind 29, 100591, 2020.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Inhibition of sodium-proton-exchanger subtype 3-mediated sodium absorption in the gut
T2 - A new antihypertensive concept
AU - Linz, Benedikt
AU - Saljic, Arnela
AU - Hohl, Mathias
AU - Gawalko, Monika
AU - Jespersen, Thomas
AU - Sanders, Prashanthan
AU - Bohm, Michael
AU - Linz, Dominik
PY - 2020
Y1 - 2020
N2 - Arterial hypertension is one of the main contributors to cardiovascular diseases, including stroke, heart failure, and coronary heart disease. Salt plays a major role in the regulation of blood pressure and is one of the most critical factors for hypertension and stroke. At the individual level, effective salt reduction is difficult to achieve and available methods for managing sodium balance are lacking for many patients. As part of the ingested food, salt is absorbed in the gastrointestinal tract by the sodium proton exchanger subtype 3 (NHE3 also known as Slc9a3), influencing extracellular fluid volume and blood pressure.In this review, we discuss the beneficial effects of pharmacological inhibition of NHE3-mediated sodium absorption in the gut and focus on the effect on blood pressure and end-organ damage. (C) 2020 Published by Elsevier B.V.
AB - Arterial hypertension is one of the main contributors to cardiovascular diseases, including stroke, heart failure, and coronary heart disease. Salt plays a major role in the regulation of blood pressure and is one of the most critical factors for hypertension and stroke. At the individual level, effective salt reduction is difficult to achieve and available methods for managing sodium balance are lacking for many patients. As part of the ingested food, salt is absorbed in the gastrointestinal tract by the sodium proton exchanger subtype 3 (NHE3 also known as Slc9a3), influencing extracellular fluid volume and blood pressure.In this review, we discuss the beneficial effects of pharmacological inhibition of NHE3-mediated sodium absorption in the gut and focus on the effect on blood pressure and end-organ damage. (C) 2020 Published by Elsevier B.V.
KW - Hypertension
KW - Blood pressure
KW - Salt
KW - Sodium-proton-exchanger
KW - Gut
KW - IRRITABLE-BOWEL-SYNDROME
KW - BLOOD-PRESSURE
KW - HUMAN MICROBIOME
KW - NHE3 EXPRESSION
KW - DIETARY-SODIUM
KW - SALT INTAKE
KW - TENAPANOR
KW - KIDNEY
KW - WATER
KW - HYPERTENSION
U2 - 10.1016/j.ijcha.2020.100591
DO - 10.1016/j.ijcha.2020.100591
M3 - Review
C2 - 32760780
VL - 29
JO - IJC Heart and Vasculature
JF - IJC Heart and Vasculature
SN - 2352-9067
M1 - 100591
ER -
ID: 248296761