Inhibition of small-conductance Ca2+-activated K+ channels terminates and protects against atrial fibrillation
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Inhibition of small-conductance Ca2+-activated K+ channels terminates and protects against atrial fibrillation. / Diness, Jonas Goldin; Sørensen, Ulrik S; Nissen, Jakob Dahl; Al-Shahib, Baha; Jespersen, Thomas; Grunnet, Morten; Hansen, Rie Schultz; Jespersen, Thomas.
I: Circulation. Arrhythmia and electrophysiology, Bind 3, Nr. 4, 08.2010, s. 380-90.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Inhibition of small-conductance Ca2+-activated K+ channels terminates and protects against atrial fibrillation
AU - Diness, Jonas Goldin
AU - Sørensen, Ulrik S
AU - Nissen, Jakob Dahl
AU - Al-Shahib, Baha
AU - Jespersen, Thomas
AU - Grunnet, Morten
AU - Hansen, Rie Schultz
AU - Jespersen, Thomas
PY - 2010/8
Y1 - 2010/8
N2 - Recently, evidence has emerged that small-conductance Ca(2+)-activated K(+) (SK) channels are predominantly expressed in the atria in a number of species including human. In rat, guinea pig, and rabbit ex vivo and in vivo models of atrial fibrillation (AF), we used 3 different SK channel inhibitors, UCL1684, N-(pyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine (ICA), and NS8593, to assess the hypothesis that pharmacological inhibition of SK channels is antiarrhythmic.
AB - Recently, evidence has emerged that small-conductance Ca(2+)-activated K(+) (SK) channels are predominantly expressed in the atria in a number of species including human. In rat, guinea pig, and rabbit ex vivo and in vivo models of atrial fibrillation (AF), we used 3 different SK channel inhibitors, UCL1684, N-(pyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine (ICA), and NS8593, to assess the hypothesis that pharmacological inhibition of SK channels is antiarrhythmic.
KW - 1-Naphthylamine
KW - Acetylcholine
KW - Action Potentials
KW - Alkanes
KW - Animals
KW - Anti-Arrhythmia Agents
KW - Atrial Fibrillation
KW - Cardiac Pacing, Artificial
KW - Dose-Response Relationship, Drug
KW - Electrocardiography
KW - Female
KW - Guinea Pigs
KW - Male
KW - Myocardium
KW - Perfusion
KW - Potassium Channel Blockers
KW - Potassium Channels, Calcium-Activated
KW - Pyridines
KW - Quinolinium Compounds
KW - Rabbits
KW - Rats
KW - Rats, Sprague-Dawley
KW - Thiazoles
KW - Time Factors
U2 - 10.1161/CIRCEP.110.957407
DO - 10.1161/CIRCEP.110.957407
M3 - Journal article
C2 - 20562443
VL - 3
SP - 380
EP - 390
JO - Circulation: Arrhythmia and Electrophysiology
JF - Circulation: Arrhythmia and Electrophysiology
SN - 1941-3149
IS - 4
ER -
ID: 33016849