Infectious mononucleosis and risk of multiple sclerosis: Proxy or culprit?
Publikation: Bidrag til tidsskrift › Leder › Forskning › fagfællebedømt
Standard
Infectious mononucleosis and risk of multiple sclerosis : Proxy or culprit? / Hjalgrim, Henrik; Rostgaard, Klaus.
I: Multiple Sclerosis Journal, Bind 30, Nr. 4-5, 2024, s. 460-462.Publikation: Bidrag til tidsskrift › Leder › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Infectious mononucleosis and risk of multiple sclerosis
T2 - Proxy or culprit?
AU - Hjalgrim, Henrik
AU - Rostgaard, Klaus
PY - 2024
Y1 - 2024
N2 - In 2022, a study published in Science presented the hitherto strongest evidence that the development of multiple sclerosis (MS) depends on infection with the Epstein–Barr virus (EBV).1 Based on serological analyses of prospective samples from the American Department of Defense Serum Repository (DoDSR), the study demonstrated that among uninfected individuals, subsequent infection with EBV was associated with a 32-fold increased risk of MS.1Meanwhile infection with other viruses was not associated with MS risk in the study. Also, serum levels of neurofilament light chain, which is a marker of neuroaxonal degeneration, began to increase only after infection with EBV, further strengthening the case against the virus.1The association between EBV and MS is interesting and important for several reasons. First, it may pave the way for a more detailed understanding of MS pathogenesis (e.g. Vietzen et al.2) and inspire the design of novel treatments.3,4 Second, it implies that MS may one day be preventable, for example, through vaccinations against EBV, encouraging efforts to develop such.
AB - In 2022, a study published in Science presented the hitherto strongest evidence that the development of multiple sclerosis (MS) depends on infection with the Epstein–Barr virus (EBV).1 Based on serological analyses of prospective samples from the American Department of Defense Serum Repository (DoDSR), the study demonstrated that among uninfected individuals, subsequent infection with EBV was associated with a 32-fold increased risk of MS.1Meanwhile infection with other viruses was not associated with MS risk in the study. Also, serum levels of neurofilament light chain, which is a marker of neuroaxonal degeneration, began to increase only after infection with EBV, further strengthening the case against the virus.1The association between EBV and MS is interesting and important for several reasons. First, it may pave the way for a more detailed understanding of MS pathogenesis (e.g. Vietzen et al.2) and inspire the design of novel treatments.3,4 Second, it implies that MS may one day be preventable, for example, through vaccinations against EBV, encouraging efforts to develop such.
U2 - 10.1177/13524585241237708
DO - 10.1177/13524585241237708
M3 - Editorial
C2 - 38511833
AN - SCOPUS:85188438601
VL - 30
SP - 460
EP - 462
JO - Multiple Sclerosis Journal
JF - Multiple Sclerosis Journal
SN - 1352-4585
IS - 4-5
ER -
ID: 387260968