Individuals with type 2 diabetes have higher density of small intestinal neurotensin-expressing cells
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Neurotensin (NT) is a gastro-intestinal hormone involved in several pathways that regulate energy and glucose homeostasis. NT was hypothesized to act in synergy with incretin hormones to potentiate its anti-diabetic effects. Additionally, circulating NT levels were shown to rise after bariatric surgery-induced weight loss. Knowledge of NT-secreting cells distribution along the small intestine and its variation according to diabetes status could provide insights on NT role in mediating type 2 diabetes (T2D) improvement after bariatric surgery. So, our aims were to characterize NT-expressing cell distribution along the human small intestine and to compare the relative density of NT-expressing cells in the small intestine of individuals with and without T2D undergoing bariatric surgery for obesity treatment. Autopsy-derived small intestine fragments (n = 30) were obtained at every 20 cm along the entire intestinal length. Additionally, jejunum biopsies (n = 29) were obtained during elective gastric bypass interventions from patients with (n = 10) or without T2D (n = 18). NT-expressing cells were identified by immunohistochemistry and quantified via computerized morphometric analysis. NT-expressing cell density increased along the human small intestine. NT-expressing cell density was significantly higher from 200 cm distal to the duodenojejunal flexure onward, as well as in subjects with T2D when compared to those without T2D. NT-expressing cell density increases along the human small gut, and a higher density is found in individuals with T2D. This finding suggests a potential role for NT in the mechanisms of disease and T2D improvement observed after bariatric surgery.
Originalsprog | Engelsk |
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Tidsskrift | Molecular and Cellular Biochemistry |
Vol/bind | 478 |
Udgave nummer | 12 |
Sider (fra-til) | 2779-2787 |
ISSN | 0300-8177 |
DOI | |
Status | Udgivet - 2023 |
Bibliografisk note
Funding Information:
Open access funding provided by FCT|FCCN (b-on). This work was funded by the Foundation for Science and Technology (FCT) through the following funds: UIDB/00215/2020, UIDP/00215/2020 and LA/P/0064/2020.
Publisher Copyright:
© 2023, The Author(s).
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