Immunohistochemical characterization of integrin alfa 6 in uterus and cervix of the cynomolgus monkeys (Macaca fascicularis) with MfPV3 infection

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Immunohistochemical characterization of integrin alfa 6 in uterus and cervix of the cynomolgus monkeys (Macaca fascicularis) with MfPV3 infection. / Setyawaty, Dyah; Mariya, Silmi; Prabandari, Silvia A.; Boilessen, Ditte Rahbaek; Holst, Peter Johannes; Darusman, Huda Shalahudin.

I: Journal of Medical Primatology, Bind 53, Nr. 1, e12690, 2024.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Setyawaty, D, Mariya, S, Prabandari, SA, Boilessen, DR, Holst, PJ & Darusman, HS 2024, 'Immunohistochemical characterization of integrin alfa 6 in uterus and cervix of the cynomolgus monkeys (Macaca fascicularis) with MfPV3 infection', Journal of Medical Primatology, bind 53, nr. 1, e12690. https://doi.org/10.1111/jmp.12690

APA

Setyawaty, D., Mariya, S., Prabandari, S. A., Boilessen, D. R., Holst, P. J., & Darusman, H. S. (2024). Immunohistochemical characterization of integrin alfa 6 in uterus and cervix of the cynomolgus monkeys (Macaca fascicularis) with MfPV3 infection. Journal of Medical Primatology, 53(1), [e12690]. https://doi.org/10.1111/jmp.12690

Vancouver

Setyawaty D, Mariya S, Prabandari SA, Boilessen DR, Holst PJ, Darusman HS. Immunohistochemical characterization of integrin alfa 6 in uterus and cervix of the cynomolgus monkeys (Macaca fascicularis) with MfPV3 infection. Journal of Medical Primatology. 2024;53(1). e12690. https://doi.org/10.1111/jmp.12690

Author

Setyawaty, Dyah ; Mariya, Silmi ; Prabandari, Silvia A. ; Boilessen, Ditte Rahbaek ; Holst, Peter Johannes ; Darusman, Huda Shalahudin. / Immunohistochemical characterization of integrin alfa 6 in uterus and cervix of the cynomolgus monkeys (Macaca fascicularis) with MfPV3 infection. I: Journal of Medical Primatology. 2024 ; Bind 53, Nr. 1.

Bibtex

@article{76f82f208bf74b55b7705dc794a8de6f,
title = "Immunohistochemical characterization of integrin alfa 6 in uterus and cervix of the cynomolgus monkeys (Macaca fascicularis) with MfPV3 infection",
abstract = "Background: Cervical cancer is an abnormal growth of cervical tissue epithelial cells due to persistent human papilloma virus (HPV) infection. Cynomolgus monkeys (Macaca fascicularis) can be naturally and spontaneously infected with M. fascicularis Papillomavirus Type 3 (MfPV3), a virus that is phylogenetically closely related to human oncogenic HPV (HPV-16 and HPV-34), and therefore a potentially beneficial for modeling HPV disease. This study aims to evaluate the expression of the integrin alpha 6 (ITGα6) receptor in cynomolgus monkeys spontaneously infected with MfPV3, which this receptor also found in human infected with HPV. Methods: The study was done on archived Formalin-fixed Paraffin-Embedded (FFPE) samples of uterine and cervix tissue of cynomolgus monkeys. Immunohistochemistry was also performed to quantify the expression levels of ITGα6. Results: The results showed 80% of the samples positive Cervical Intraepithelial Neoplasia (CIN) and increased expression of ITGα6 significantly in Positive-MfPV3 group than negative-MfPV3 group. Conclusions: This indicated the potential of cynomolgus monkeys as a spontaneous oncogenesis model of PV infection type.",
keywords = "cynomolgus monkeys, human papilloma virus, immunohistochemistry, ITGα6",
author = "Dyah Setyawaty and Silmi Mariya and Prabandari, {Silvia A.} and Boilessen, {Ditte Rahbaek} and Holst, {Peter Johannes} and Darusman, {Huda Shalahudin}",
note = "Publisher Copyright: {\textcopyright} 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.",
year = "2024",
doi = "10.1111/jmp.12690",
language = "English",
volume = "53",
journal = "Journal of Medical Primatology",
issn = "0047-2565",
publisher = "Wiley-Blackwell",
number = "1",

}

RIS

TY - JOUR

T1 - Immunohistochemical characterization of integrin alfa 6 in uterus and cervix of the cynomolgus monkeys (Macaca fascicularis) with MfPV3 infection

AU - Setyawaty, Dyah

AU - Mariya, Silmi

AU - Prabandari, Silvia A.

AU - Boilessen, Ditte Rahbaek

AU - Holst, Peter Johannes

AU - Darusman, Huda Shalahudin

N1 - Publisher Copyright: © 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

PY - 2024

Y1 - 2024

N2 - Background: Cervical cancer is an abnormal growth of cervical tissue epithelial cells due to persistent human papilloma virus (HPV) infection. Cynomolgus monkeys (Macaca fascicularis) can be naturally and spontaneously infected with M. fascicularis Papillomavirus Type 3 (MfPV3), a virus that is phylogenetically closely related to human oncogenic HPV (HPV-16 and HPV-34), and therefore a potentially beneficial for modeling HPV disease. This study aims to evaluate the expression of the integrin alpha 6 (ITGα6) receptor in cynomolgus monkeys spontaneously infected with MfPV3, which this receptor also found in human infected with HPV. Methods: The study was done on archived Formalin-fixed Paraffin-Embedded (FFPE) samples of uterine and cervix tissue of cynomolgus monkeys. Immunohistochemistry was also performed to quantify the expression levels of ITGα6. Results: The results showed 80% of the samples positive Cervical Intraepithelial Neoplasia (CIN) and increased expression of ITGα6 significantly in Positive-MfPV3 group than negative-MfPV3 group. Conclusions: This indicated the potential of cynomolgus monkeys as a spontaneous oncogenesis model of PV infection type.

AB - Background: Cervical cancer is an abnormal growth of cervical tissue epithelial cells due to persistent human papilloma virus (HPV) infection. Cynomolgus monkeys (Macaca fascicularis) can be naturally and spontaneously infected with M. fascicularis Papillomavirus Type 3 (MfPV3), a virus that is phylogenetically closely related to human oncogenic HPV (HPV-16 and HPV-34), and therefore a potentially beneficial for modeling HPV disease. This study aims to evaluate the expression of the integrin alpha 6 (ITGα6) receptor in cynomolgus monkeys spontaneously infected with MfPV3, which this receptor also found in human infected with HPV. Methods: The study was done on archived Formalin-fixed Paraffin-Embedded (FFPE) samples of uterine and cervix tissue of cynomolgus monkeys. Immunohistochemistry was also performed to quantify the expression levels of ITGα6. Results: The results showed 80% of the samples positive Cervical Intraepithelial Neoplasia (CIN) and increased expression of ITGα6 significantly in Positive-MfPV3 group than negative-MfPV3 group. Conclusions: This indicated the potential of cynomolgus monkeys as a spontaneous oncogenesis model of PV infection type.

KW - cynomolgus monkeys

KW - human papilloma virus

KW - immunohistochemistry

KW - ITGα6

U2 - 10.1111/jmp.12690

DO - 10.1111/jmp.12690

M3 - Journal article

C2 - 38345331

AN - SCOPUS:85182478571

VL - 53

JO - Journal of Medical Primatology

JF - Journal of Medical Primatology

SN - 0047-2565

IS - 1

M1 - e12690

ER -

ID: 389796096