Immune response and protection of cattle and pigs generated by a vaccinia virus recombinant expressing the F protein of rinderpest virus.
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Immune response and protection of cattle and pigs generated by a vaccinia virus recombinant expressing the F protein of rinderpest virus. / Belsham, G. J.; Anderson, E. C.; Murray, P. K.; Anderson, J.; Barrett, T.
I: The Veterinary Record, Bind 124, Nr. 25, 24.06.1989, s. 655-658.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Immune response and protection of cattle and pigs generated by a vaccinia virus recombinant expressing the F protein of rinderpest virus.
AU - Belsham, G. J.
AU - Anderson, E. C.
AU - Murray, P. K.
AU - Anderson, J.
AU - Barrett, T.
PY - 1989/6/24
Y1 - 1989/6/24
N2 - The immune response of cattle and pigs to a vaccinia recombinant virus containing the fusion (F) protein gene of rinderpest virus was examined. Half the cattle and all the pigs gave humoral response to primary vaccination and all the cattle gave an anamnestic response to a second vaccination 28 days after the primary vaccination. All the cattle after a single or secondary vaccination were completely protected clinically after exposure to a lethal dose of the Saudi 1/81 strain of virus. Prior vaccination with another TK- vaccinia recombinant (VVCAT) suppressed, but did not abrogate, the immune response to the rinderpest F recombinant. The pigs gave a humoral immune response in the absence of any local reaction at the site of vaccination.
AB - The immune response of cattle and pigs to a vaccinia recombinant virus containing the fusion (F) protein gene of rinderpest virus was examined. Half the cattle and all the pigs gave humoral response to primary vaccination and all the cattle gave an anamnestic response to a second vaccination 28 days after the primary vaccination. All the cattle after a single or secondary vaccination were completely protected clinically after exposure to a lethal dose of the Saudi 1/81 strain of virus. Prior vaccination with another TK- vaccinia recombinant (VVCAT) suppressed, but did not abrogate, the immune response to the rinderpest F recombinant. The pigs gave a humoral immune response in the absence of any local reaction at the site of vaccination.
UR - http://www.scopus.com/inward/record.url?scp=0024977645&partnerID=8YFLogxK
U2 - 10.1136/vr.124.25.655
DO - 10.1136/vr.124.25.655
M3 - Journal article
C2 - 2763430
AN - SCOPUS:0024977645
VL - 124
SP - 655
EP - 658
JO - Veterinary Record
JF - Veterinary Record
SN - 0042-4900
IS - 25
ER -
ID: 381229261