Immune Cell Alterations in Psychotic Disorders: A Comprehensive Systematic Review and Meta-analysis

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Standard

Immune Cell Alterations in Psychotic Disorders : A Comprehensive Systematic Review and Meta-analysis. / Clausen, Max; Christensen, Rune H. B.; da Re, Maria; Benros, Michael E.

I: Biological Psychiatry, Bind 96, Nr. 5, 2024, s. 331-341.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Clausen, M, Christensen, RHB, da Re, M & Benros, ME 2024, 'Immune Cell Alterations in Psychotic Disorders: A Comprehensive Systematic Review and Meta-analysis', Biological Psychiatry, bind 96, nr. 5, s. 331-341. https://doi.org/10.1016/j.biopsych.2023.11.029

APA

Clausen, M., Christensen, R. H. B., da Re, M., & Benros, M. E. (2024). Immune Cell Alterations in Psychotic Disorders: A Comprehensive Systematic Review and Meta-analysis. Biological Psychiatry, 96(5), 331-341. https://doi.org/10.1016/j.biopsych.2023.11.029

Vancouver

Clausen M, Christensen RHB, da Re M, Benros ME. Immune Cell Alterations in Psychotic Disorders: A Comprehensive Systematic Review and Meta-analysis. Biological Psychiatry. 2024;96(5):331-341. https://doi.org/10.1016/j.biopsych.2023.11.029

Author

Clausen, Max ; Christensen, Rune H. B. ; da Re, Maria ; Benros, Michael E. / Immune Cell Alterations in Psychotic Disorders : A Comprehensive Systematic Review and Meta-analysis. I: Biological Psychiatry. 2024 ; Bind 96, Nr. 5. s. 331-341.

Bibtex

@article{5ec64c86d5e64b54a53e8a581ad6029a,
title = "Immune Cell Alterations in Psychotic Disorders: A Comprehensive Systematic Review and Meta-analysis",
abstract = "BACKGROUND: A comprehensive meta-analysis on the composition of circulating immune cells from both the myeloid and lymphoid line including specialized subsets in blood and cerebrospinal fluid (CSF) of patients with psychotic disorders compared to healthy controls have been lacking.METHODS: Multiple databases (PubMed, EMBASE, Cochrane Library, Web of Science, ClinicalTrials.gov and PsycINFO) were searched for eligible studies up until October 18, 2022. All studies investigating circulating immune cells in the blood and CSF from patients with psychotic disorders (ICD-10: F20 and F22-29) compared to healthy controls were included.RESULTS: A total of 86 studies were included in the meta-analysis. In the blood, the following categories of immune cells were elevated: leukocyte count (31 studies, SMD=0.35; 95%-CI: 0.24-0.46), granulocyte count (4 studies, SMD=0.57; 95%-CI: 0.12-1.01), neutrophile granulocyte count (21 studies, SMD=0.32; 95%-CI: 0.11-0.54), monocyte count (23 studies, SMD=0.40; 95%-CI: 0.23-0.56) and B lymphocyte count (10 studies, SMD=0.26; 95%-CI: 0.04-0.48). Additionally, the neutrophile/lymphocyte ratio (23 studies, SMD=0.40; 95%-CI: 0.19-0.60), the monocyte/lymphocyte ratio (9 studies, SMD=0.31; 95%-CI: 0.04-0.57), and the platelet/lymphocyte ratio (10 studies, SMD=0.23; 95%-CI: 0.03-0.43) were elevated. The CSF cell count showed similar tendency but was not significantly elevated (3 studies, SMD = 0.14; 95%-CI: -0.04 to 0.32).CONCLUSION: The results indicate a broad activation of the immune system in psychotic disorders with cells from both the myeloid and the lymphoid line being elevated. However, CSF analyses were lacking in most of the studies, and many studies were hampered by insufficient adjustment for confounding factors as BMI and smoking.",
author = "Max Clausen and Christensen, {Rune H. B.} and {da Re}, Maria and Benros, {Michael E.}",
note = "Copyright {\textcopyright} 2024. Published by Elsevier Inc.",
year = "2024",
doi = "10.1016/j.biopsych.2023.11.029",
language = "English",
volume = "96",
pages = "331--341",
journal = "Biological Psychiatry",
issn = "0006-3223",
publisher = "Elsevier",
number = "5",

}

RIS

TY - JOUR

T1 - Immune Cell Alterations in Psychotic Disorders

T2 - A Comprehensive Systematic Review and Meta-analysis

AU - Clausen, Max

AU - Christensen, Rune H. B.

AU - da Re, Maria

AU - Benros, Michael E.

N1 - Copyright © 2024. Published by Elsevier Inc.

PY - 2024

Y1 - 2024

N2 - BACKGROUND: A comprehensive meta-analysis on the composition of circulating immune cells from both the myeloid and lymphoid line including specialized subsets in blood and cerebrospinal fluid (CSF) of patients with psychotic disorders compared to healthy controls have been lacking.METHODS: Multiple databases (PubMed, EMBASE, Cochrane Library, Web of Science, ClinicalTrials.gov and PsycINFO) were searched for eligible studies up until October 18, 2022. All studies investigating circulating immune cells in the blood and CSF from patients with psychotic disorders (ICD-10: F20 and F22-29) compared to healthy controls were included.RESULTS: A total of 86 studies were included in the meta-analysis. In the blood, the following categories of immune cells were elevated: leukocyte count (31 studies, SMD=0.35; 95%-CI: 0.24-0.46), granulocyte count (4 studies, SMD=0.57; 95%-CI: 0.12-1.01), neutrophile granulocyte count (21 studies, SMD=0.32; 95%-CI: 0.11-0.54), monocyte count (23 studies, SMD=0.40; 95%-CI: 0.23-0.56) and B lymphocyte count (10 studies, SMD=0.26; 95%-CI: 0.04-0.48). Additionally, the neutrophile/lymphocyte ratio (23 studies, SMD=0.40; 95%-CI: 0.19-0.60), the monocyte/lymphocyte ratio (9 studies, SMD=0.31; 95%-CI: 0.04-0.57), and the platelet/lymphocyte ratio (10 studies, SMD=0.23; 95%-CI: 0.03-0.43) were elevated. The CSF cell count showed similar tendency but was not significantly elevated (3 studies, SMD = 0.14; 95%-CI: -0.04 to 0.32).CONCLUSION: The results indicate a broad activation of the immune system in psychotic disorders with cells from both the myeloid and the lymphoid line being elevated. However, CSF analyses were lacking in most of the studies, and many studies were hampered by insufficient adjustment for confounding factors as BMI and smoking.

AB - BACKGROUND: A comprehensive meta-analysis on the composition of circulating immune cells from both the myeloid and lymphoid line including specialized subsets in blood and cerebrospinal fluid (CSF) of patients with psychotic disorders compared to healthy controls have been lacking.METHODS: Multiple databases (PubMed, EMBASE, Cochrane Library, Web of Science, ClinicalTrials.gov and PsycINFO) were searched for eligible studies up until October 18, 2022. All studies investigating circulating immune cells in the blood and CSF from patients with psychotic disorders (ICD-10: F20 and F22-29) compared to healthy controls were included.RESULTS: A total of 86 studies were included in the meta-analysis. In the blood, the following categories of immune cells were elevated: leukocyte count (31 studies, SMD=0.35; 95%-CI: 0.24-0.46), granulocyte count (4 studies, SMD=0.57; 95%-CI: 0.12-1.01), neutrophile granulocyte count (21 studies, SMD=0.32; 95%-CI: 0.11-0.54), monocyte count (23 studies, SMD=0.40; 95%-CI: 0.23-0.56) and B lymphocyte count (10 studies, SMD=0.26; 95%-CI: 0.04-0.48). Additionally, the neutrophile/lymphocyte ratio (23 studies, SMD=0.40; 95%-CI: 0.19-0.60), the monocyte/lymphocyte ratio (9 studies, SMD=0.31; 95%-CI: 0.04-0.57), and the platelet/lymphocyte ratio (10 studies, SMD=0.23; 95%-CI: 0.03-0.43) were elevated. The CSF cell count showed similar tendency but was not significantly elevated (3 studies, SMD = 0.14; 95%-CI: -0.04 to 0.32).CONCLUSION: The results indicate a broad activation of the immune system in psychotic disorders with cells from both the myeloid and the lymphoid line being elevated. However, CSF analyses were lacking in most of the studies, and many studies were hampered by insufficient adjustment for confounding factors as BMI and smoking.

U2 - 10.1016/j.biopsych.2023.11.029

DO - 10.1016/j.biopsych.2023.11.029

M3 - Journal article

C2 - 38185237

VL - 96

SP - 331

EP - 341

JO - Biological Psychiatry

JF - Biological Psychiatry

SN - 0006-3223

IS - 5

ER -

ID: 379352985