IL-6 has no acute effect on the regulation of urea synthesis in vivo in rats
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Clinical or experimentally induced, active inflammation up-regulates the in vivo capacity of urea synthesis (CUNS), which promotes nitrogen removal from the body and metabolic catabolism. We have shown that tumor necrosis factor a (TNF-a) up-regulates CUNS and increases interleukin 6 expression (IL-6) within hours of administration. The described effect of TNF-a on nitrogen homeostasis may, therefore, depend on IL-6.
Originalsprog | Engelsk |
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Tidsskrift | Scandinavian Journal of Clinical & Laboratory Investigation |
Vol/bind | 71 |
Udgave nummer | 2 |
Sider (fra-til) | 150-156 |
Antal sider | 7 |
ISSN | 0036-5513 |
DOI | |
Status | Udgivet - apr. 2011 |
ID: 38531833