IL-6 gene polymorphism in rheumatoid arthritis, pauciarticular juvenile rheumatoid arthritis, systemic lupus erythematosus, and in healthy Danes
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IL-6 gene polymorphism in rheumatoid arthritis, pauciarticular juvenile rheumatoid arthritis, systemic lupus erythematosus, and in healthy Danes. / Fugger, L; Morling, N; Bendtzen, K; Ryder, L; Andersen, V; Heilman, C; Karup Pedersen, F; Friis, J; Halbert, P; Svejgaard, A.
I: Journal of Immunogenetics, Bind 16, Nr. 6, 1989, s. 461-5.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - IL-6 gene polymorphism in rheumatoid arthritis, pauciarticular juvenile rheumatoid arthritis, systemic lupus erythematosus, and in healthy Danes
AU - Fugger, L
AU - Morling, N
AU - Bendtzen, K
AU - Ryder, L
AU - Andersen, V
AU - Heilman, C
AU - Karup Pedersen, F
AU - Friis, J
AU - Halbert, P
AU - Svejgaard, A
N1 - Keywords: Arthritis, Juvenile Rheumatoid; Arthritis, Rheumatoid; DNA; Denmark; Gene Frequency; Genetic Markers; Humans; Interleukin-6; Lupus Erythematosus, Systemic; Phenotype; Polymorphism, Restriction Fragment Length
PY - 1989
Y1 - 1989
N2 - The restriction enzymes MspI and BglII identify two different two-allele restriction fragment length polymorphisms (RFLP) in the human IL-6 genes of healthy Danes. Co-dominant segregation was demonstrated for both marker-systems and the test for Hardy-Weinberg equilibrium showed no significant deviation from expectations. There is a strong correlation between the two marker systems. The two IL-6 RFLP's were studied in Danish patients with rheumatoid arthritis, pauciarticular juvenile rheumatoid arthritis, and systemic lupus erythematosus. The frequencies of the MspI and BglII marker phenotypes did not differ between healthy controls and the three disease groups. No extra or missing DNA fragments were observed in the disease groups when compared with controls.
AB - The restriction enzymes MspI and BglII identify two different two-allele restriction fragment length polymorphisms (RFLP) in the human IL-6 genes of healthy Danes. Co-dominant segregation was demonstrated for both marker-systems and the test for Hardy-Weinberg equilibrium showed no significant deviation from expectations. There is a strong correlation between the two marker systems. The two IL-6 RFLP's were studied in Danish patients with rheumatoid arthritis, pauciarticular juvenile rheumatoid arthritis, and systemic lupus erythematosus. The frequencies of the MspI and BglII marker phenotypes did not differ between healthy controls and the three disease groups. No extra or missing DNA fragments were observed in the disease groups when compared with controls.
M3 - Journal article
C2 - 2577114
VL - 16
SP - 461
EP - 465
JO - Journal of Immunogenetics
JF - Journal of Immunogenetics
SN - 0305-1811
IS - 6
ER -
ID: 21610463