Identification of the mononuclear cell infiltrate in the superior cervical ganglion of athymic nude and euthymic rats after guanethidine-induced sympathectomy

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Standard

Identification of the mononuclear cell infiltrate in the superior cervical ganglion of athymic nude and euthymic rats after guanethidine-induced sympathectomy. / Thygesen, P; Hougen, H P; Christensen, H B; Rygaard, J; Svendsen, O; Juul, P.

I: International Journal of Immunopharmacology, Bind 12, Nr. 3, 1990, s. 327-30.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Thygesen, P, Hougen, HP, Christensen, HB, Rygaard, J, Svendsen, O & Juul, P 1990, 'Identification of the mononuclear cell infiltrate in the superior cervical ganglion of athymic nude and euthymic rats after guanethidine-induced sympathectomy', International Journal of Immunopharmacology, bind 12, nr. 3, s. 327-30.

APA

Thygesen, P., Hougen, H. P., Christensen, H. B., Rygaard, J., Svendsen, O., & Juul, P. (1990). Identification of the mononuclear cell infiltrate in the superior cervical ganglion of athymic nude and euthymic rats after guanethidine-induced sympathectomy. International Journal of Immunopharmacology, 12(3), 327-30.

Vancouver

Thygesen P, Hougen HP, Christensen HB, Rygaard J, Svendsen O, Juul P. Identification of the mononuclear cell infiltrate in the superior cervical ganglion of athymic nude and euthymic rats after guanethidine-induced sympathectomy. International Journal of Immunopharmacology. 1990;12(3):327-30.

Author

Thygesen, P ; Hougen, H P ; Christensen, H B ; Rygaard, J ; Svendsen, O ; Juul, P. / Identification of the mononuclear cell infiltrate in the superior cervical ganglion of athymic nude and euthymic rats after guanethidine-induced sympathectomy. I: International Journal of Immunopharmacology. 1990 ; Bind 12, Nr. 3. s. 327-30.

Bibtex

@article{a3be01f642e147569f68d42dd921f4b1,
title = "Identification of the mononuclear cell infiltrate in the superior cervical ganglion of athymic nude and euthymic rats after guanethidine-induced sympathectomy",
abstract = "Guanethidine sulphate 40 mg/kg intraperitoneally for 14 days induced chromatolysis and nerve cell death in the superior cervical ganglia of athymic nude (rnu/rnu) LEW/Mol rats and their euthymic (+/rnu) LEW/Mol heterozygous littermates. Histologically the sympathetic ganglia were dominated by an infiltration of small inflammatory cells. By means of monoclonal antibodies these cells were identified. The number of B-lymphocytes increased following guanethidine in both athymic and euthymic rats. The number of T-lymphocytes increased to a great extent in euthymic rats, but was virtually missing in athymic rats. The number of NK-cells and monocytes/macrophages increased in both athymic and euthymic rats. The conclusion is, that guanethidine exerts a direct effect on sympathetic ganglion cells followed by a thymus-independent immune response.",
keywords = "Animals, Antibodies, Monoclonal, B-Lymphocytes, Body Weight, Cell Count, Ganglia, Sympathetic, Guanethidine, Immunoenzyme Techniques, Killer Cells, Natural, Leukocytes, Mononuclear, Male, Organ Size, Rats, Rats, Mutant Strains, Rats, Nude, Spleen, Sympathectomy, Chemical",
author = "P Thygesen and Hougen, {H P} and Christensen, {H B} and J Rygaard and O Svendsen and P Juul",
year = "1990",
language = "English",
volume = "12",
pages = "327--30",
journal = "International Journal of Immunopharmacology",
issn = "0192-0561",
publisher = "Elsevier",
number = "3",

}

RIS

TY - JOUR

T1 - Identification of the mononuclear cell infiltrate in the superior cervical ganglion of athymic nude and euthymic rats after guanethidine-induced sympathectomy

AU - Thygesen, P

AU - Hougen, H P

AU - Christensen, H B

AU - Rygaard, J

AU - Svendsen, O

AU - Juul, P

PY - 1990

Y1 - 1990

N2 - Guanethidine sulphate 40 mg/kg intraperitoneally for 14 days induced chromatolysis and nerve cell death in the superior cervical ganglia of athymic nude (rnu/rnu) LEW/Mol rats and their euthymic (+/rnu) LEW/Mol heterozygous littermates. Histologically the sympathetic ganglia were dominated by an infiltration of small inflammatory cells. By means of monoclonal antibodies these cells were identified. The number of B-lymphocytes increased following guanethidine in both athymic and euthymic rats. The number of T-lymphocytes increased to a great extent in euthymic rats, but was virtually missing in athymic rats. The number of NK-cells and monocytes/macrophages increased in both athymic and euthymic rats. The conclusion is, that guanethidine exerts a direct effect on sympathetic ganglion cells followed by a thymus-independent immune response.

AB - Guanethidine sulphate 40 mg/kg intraperitoneally for 14 days induced chromatolysis and nerve cell death in the superior cervical ganglia of athymic nude (rnu/rnu) LEW/Mol rats and their euthymic (+/rnu) LEW/Mol heterozygous littermates. Histologically the sympathetic ganglia were dominated by an infiltration of small inflammatory cells. By means of monoclonal antibodies these cells were identified. The number of B-lymphocytes increased following guanethidine in both athymic and euthymic rats. The number of T-lymphocytes increased to a great extent in euthymic rats, but was virtually missing in athymic rats. The number of NK-cells and monocytes/macrophages increased in both athymic and euthymic rats. The conclusion is, that guanethidine exerts a direct effect on sympathetic ganglion cells followed by a thymus-independent immune response.

KW - Animals

KW - Antibodies, Monoclonal

KW - B-Lymphocytes

KW - Body Weight

KW - Cell Count

KW - Ganglia, Sympathetic

KW - Guanethidine

KW - Immunoenzyme Techniques

KW - Killer Cells, Natural

KW - Leukocytes, Mononuclear

KW - Male

KW - Organ Size

KW - Rats

KW - Rats, Mutant Strains

KW - Rats, Nude

KW - Spleen

KW - Sympathectomy, Chemical

M3 - Journal article

C2 - 2184138

VL - 12

SP - 327

EP - 330

JO - International Journal of Immunopharmacology

JF - International Journal of Immunopharmacology

SN - 0192-0561

IS - 3

ER -

ID: 44514488