Host defense peptides human β defensin 2 and LL-37 ameliorate murine necrotizing enterocolitis

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Standard

Host defense peptides human β defensin 2 and LL-37 ameliorate murine necrotizing enterocolitis. / Lueschow-Guijosa, Shiloh R.; Stanford, Amy H.; Berger, Jennifer N.; Gong, Huiyu; Boly, Timothy J.; Jensen, Benjamin A.H.; Nordkild, Peter; Leegwater, Alexandra J.; Wehkamp, Jan; Underwood, Mark A.; McElroy, Steven J.

I: iScience, Bind 27, Nr. 6, 109993, 2024.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Lueschow-Guijosa, SR, Stanford, AH, Berger, JN, Gong, H, Boly, TJ, Jensen, BAH, Nordkild, P, Leegwater, AJ, Wehkamp, J, Underwood, MA & McElroy, SJ 2024, 'Host defense peptides human β defensin 2 and LL-37 ameliorate murine necrotizing enterocolitis', iScience, bind 27, nr. 6, 109993. https://doi.org/10.1016/j.isci.2024.109993

APA

Lueschow-Guijosa, S. R., Stanford, A. H., Berger, J. N., Gong, H., Boly, T. J., Jensen, B. A. H., Nordkild, P., Leegwater, A. J., Wehkamp, J., Underwood, M. A., & McElroy, S. J. (2024). Host defense peptides human β defensin 2 and LL-37 ameliorate murine necrotizing enterocolitis. iScience, 27(6), [109993]. https://doi.org/10.1016/j.isci.2024.109993

Vancouver

Lueschow-Guijosa SR, Stanford AH, Berger JN, Gong H, Boly TJ, Jensen BAH o.a. Host defense peptides human β defensin 2 and LL-37 ameliorate murine necrotizing enterocolitis. iScience. 2024;27(6). 109993. https://doi.org/10.1016/j.isci.2024.109993

Author

Lueschow-Guijosa, Shiloh R. ; Stanford, Amy H. ; Berger, Jennifer N. ; Gong, Huiyu ; Boly, Timothy J. ; Jensen, Benjamin A.H. ; Nordkild, Peter ; Leegwater, Alexandra J. ; Wehkamp, Jan ; Underwood, Mark A. ; McElroy, Steven J. / Host defense peptides human β defensin 2 and LL-37 ameliorate murine necrotizing enterocolitis. I: iScience. 2024 ; Bind 27, Nr. 6.

Bibtex

@article{51736806c5ed4941a64836e26a92ac30,
title = "Host defense peptides human β defensin 2 and LL-37 ameliorate murine necrotizing enterocolitis",
abstract = "Necrotizing enterocolitis (NEC) is a leading cause of preterm infant morbidity and mortality. Treatment for NEC is limited and non-targeted, which makes new treatment and prevention strategies critical. Host defense peptides (HDPs) are essential components of the innate immune system and have multifactorial mechanisms in host defense. LL-37 and hBD2 are two HDPs that have been shown in prior literature to protect from neonatal sepsis-induced mortality or adult inflammatory bowel disease, respectively. Therefore, this article sought to understand if these two HDPs could influence NEC severity in murine preclinical models. NEC was induced in P14-16 C57Bl/6 mice and HDPs were provided as a pretreatment or treatment. Both LL-37 and hBD2 resulted in decreased NEC injury scores as a treatment and hBD2 as a pretreatment. Our data suggest LL-37 functions through antimicrobial properties, while hBD2 functions through decreases in inflammation and improvement of intestinal barrier integrity.",
keywords = "Biological sciences, Immunology, Molecular biology",
author = "Lueschow-Guijosa, {Shiloh R.} and Stanford, {Amy H.} and Berger, {Jennifer N.} and Huiyu Gong and Boly, {Timothy J.} and Jensen, {Benjamin A.H.} and Peter Nordkild and Leegwater, {Alexandra J.} and Jan Wehkamp and Underwood, {Mark A.} and McElroy, {Steven J.}",
note = "Publisher Copyright: {\textcopyright} 2024 The Authors",
year = "2024",
doi = "10.1016/j.isci.2024.109993",
language = "English",
volume = "27",
journal = "iScience",
issn = "2589-0042",
publisher = "Elsevier",
number = "6",

}

RIS

TY - JOUR

T1 - Host defense peptides human β defensin 2 and LL-37 ameliorate murine necrotizing enterocolitis

AU - Lueschow-Guijosa, Shiloh R.

AU - Stanford, Amy H.

AU - Berger, Jennifer N.

AU - Gong, Huiyu

AU - Boly, Timothy J.

AU - Jensen, Benjamin A.H.

AU - Nordkild, Peter

AU - Leegwater, Alexandra J.

AU - Wehkamp, Jan

AU - Underwood, Mark A.

AU - McElroy, Steven J.

N1 - Publisher Copyright: © 2024 The Authors

PY - 2024

Y1 - 2024

N2 - Necrotizing enterocolitis (NEC) is a leading cause of preterm infant morbidity and mortality. Treatment for NEC is limited and non-targeted, which makes new treatment and prevention strategies critical. Host defense peptides (HDPs) are essential components of the innate immune system and have multifactorial mechanisms in host defense. LL-37 and hBD2 are two HDPs that have been shown in prior literature to protect from neonatal sepsis-induced mortality or adult inflammatory bowel disease, respectively. Therefore, this article sought to understand if these two HDPs could influence NEC severity in murine preclinical models. NEC was induced in P14-16 C57Bl/6 mice and HDPs were provided as a pretreatment or treatment. Both LL-37 and hBD2 resulted in decreased NEC injury scores as a treatment and hBD2 as a pretreatment. Our data suggest LL-37 functions through antimicrobial properties, while hBD2 functions through decreases in inflammation and improvement of intestinal barrier integrity.

AB - Necrotizing enterocolitis (NEC) is a leading cause of preterm infant morbidity and mortality. Treatment for NEC is limited and non-targeted, which makes new treatment and prevention strategies critical. Host defense peptides (HDPs) are essential components of the innate immune system and have multifactorial mechanisms in host defense. LL-37 and hBD2 are two HDPs that have been shown in prior literature to protect from neonatal sepsis-induced mortality or adult inflammatory bowel disease, respectively. Therefore, this article sought to understand if these two HDPs could influence NEC severity in murine preclinical models. NEC was induced in P14-16 C57Bl/6 mice and HDPs were provided as a pretreatment or treatment. Both LL-37 and hBD2 resulted in decreased NEC injury scores as a treatment and hBD2 as a pretreatment. Our data suggest LL-37 functions through antimicrobial properties, while hBD2 functions through decreases in inflammation and improvement of intestinal barrier integrity.

KW - Biological sciences

KW - Immunology

KW - Molecular biology

U2 - 10.1016/j.isci.2024.109993

DO - 10.1016/j.isci.2024.109993

M3 - Journal article

AN - SCOPUS:85194103706

VL - 27

JO - iScience

JF - iScience

SN - 2589-0042

IS - 6

M1 - 109993

ER -

ID: 393508620