HLA-B27 in juvenile chronic arthritis
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HLA-B27 in juvenile chronic arthritis. / Friis, J; Morling, N; Pedersen, F K; Heilmann, C; Jørgensen, B; Svejgaard, A; Thomsen, K.
I: Journal of Rheumatology, Bind 12, Nr. 1, 1985, s. 119-22.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - HLA-B27 in juvenile chronic arthritis
AU - Friis, J
AU - Morling, N
AU - Pedersen, F K
AU - Heilmann, C
AU - Jørgensen, B
AU - Svejgaard, A
AU - Thomsen, K
N1 - Keywords: Adolescent; Adult; Arthritis; Child; Child, Preschool; HLA Antigens; HLA-B Antigens; HLA-B27 Antigen; Humans; Male; Sex Factors; Time Factors
PY - 1985
Y1 - 1985
N2 - The prevalence of HLA-B27 in 88 patients with juvenile chronic arthritis was 22/88 (25%) with little variation among the 3 commonly recognized onset types. This was significantly more frequent than the prevalence of 9.4% in a Danish reference population. A strong association was found between the HLA-B27 antigen and 3 subgroups of patients: (1) boys with pauciarticular and late onset disease; (2) girls with apophyseal joint fusion; (3) a group of patients in whom the clinical picture was compatible with reactive arthritis or incomplete Reiter's syndrome. When these 3 subgroups were excluded from the total patient population, only 8 of the remaining 63 patients carried the B27 antigen, i.e., 13%, which was not significantly different from the prevalence in the reference population. Thus, the 3 subgroups account completely for the increase of B27 in the entire group of patients.
AB - The prevalence of HLA-B27 in 88 patients with juvenile chronic arthritis was 22/88 (25%) with little variation among the 3 commonly recognized onset types. This was significantly more frequent than the prevalence of 9.4% in a Danish reference population. A strong association was found between the HLA-B27 antigen and 3 subgroups of patients: (1) boys with pauciarticular and late onset disease; (2) girls with apophyseal joint fusion; (3) a group of patients in whom the clinical picture was compatible with reactive arthritis or incomplete Reiter's syndrome. When these 3 subgroups were excluded from the total patient population, only 8 of the remaining 63 patients carried the B27 antigen, i.e., 13%, which was not significantly different from the prevalence in the reference population. Thus, the 3 subgroups account completely for the increase of B27 in the entire group of patients.
M3 - Journal article
C2 - 3872365
VL - 12
SP - 119
EP - 122
JO - Journal of Rheumatology
JF - Journal of Rheumatology
SN - 0315-162X
IS - 1
ER -
ID: 21610764