HLA studies of endemic african kaposi's sarcoma patients and matched controls: No association with hla‐DR5
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HLA studies of endemic african kaposi's sarcoma patients and matched controls : No association with hla‐DR5. / Melbye, Mads; Kestens, Luc; Gigase, Paul L.; Biggar, Robert J.; Schreuder, Geziena M.T.
I: International Journal of Cancer, Bind 39, Nr. 2, 15.02.1987, s. 182-184.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - HLA studies of endemic african kaposi's sarcoma patients and matched controls
T2 - No association with hla‐DR5
AU - Melbye, Mads
AU - Kestens, Luc
AU - Gigase, Paul L.
AU - Biggar, Robert J.
AU - Schreuder, Geziena M.T.
PY - 1987/2/15
Y1 - 1987/2/15
N2 - In the search for a genetic factor involved in the etiology of Kaposi's sarcoma, several studies have recently focused on a significantly increased HLA determinant, DR5, as well as a decreased DR3, among patients with both the classical and the AIDS‐related form of Kaposi's sarcoma. To test the consistency of this phenomenon, we analysed the frequencies of HLA immunogenetic markers in 23 histologically confirmed Kaposi's sarcoma patients from Central Africa, where this tumor is endemic, and a local sex‐ and tribe‐matched control group. No definite association was observed for any of the HLA antigens, including DR5 and DR3. We were not able to support the hypothesis that the same HLA‐associated immune susceptibility factors are involved in all types of Kaposi's sarcoma.
AB - In the search for a genetic factor involved in the etiology of Kaposi's sarcoma, several studies have recently focused on a significantly increased HLA determinant, DR5, as well as a decreased DR3, among patients with both the classical and the AIDS‐related form of Kaposi's sarcoma. To test the consistency of this phenomenon, we analysed the frequencies of HLA immunogenetic markers in 23 histologically confirmed Kaposi's sarcoma patients from Central Africa, where this tumor is endemic, and a local sex‐ and tribe‐matched control group. No definite association was observed for any of the HLA antigens, including DR5 and DR3. We were not able to support the hypothesis that the same HLA‐associated immune susceptibility factors are involved in all types of Kaposi's sarcoma.
UR - http://www.scopus.com/inward/record.url?scp=0023139425&partnerID=8YFLogxK
U2 - 10.1002/ijc.2910390210
DO - 10.1002/ijc.2910390210
M3 - Journal article
C2 - 3492448
AN - SCOPUS:0023139425
VL - 39
SP - 182
EP - 184
JO - Acta - Unio Internationalis Contra Cancrum
JF - Acta - Unio Internationalis Contra Cancrum
SN - 0898-6924
IS - 2
ER -
ID: 260893137