"High-Risk" Clinical and Inflammatory Clusters in COPD of Chinese Descent

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

"High-Risk" Clinical and Inflammatory Clusters in COPD of Chinese Descent. / Tiew, Pei Yee; Ko, Fanny Wai San; Narayana, Jayanth Kumar; Poh, Mau Ern; Xu, Huiying; Neo, Han Yee; Loh, Li-Cher; Ong, Choo Khoon; Mac Aogáin, Micheál; Tan, Jessica Han Ying; Kamaruddin, Nabilah Husna; Sim, Gerald Jiong Hui; Lapperre, Therese S; Koh, Mariko Siyue; Hui, David Shu Cheong; Abisheganaden, John Arputhan; Tee, Augustine; Tsaneva-Atanasova, Krasimira; Chotirmall, Sanjay H.

I: Chest, Bind 158, Nr. 1, 07.2020, s. 145-156.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Tiew, PY, Ko, FWS, Narayana, JK, Poh, ME, Xu, H, Neo, HY, Loh, L-C, Ong, CK, Mac Aogáin, M, Tan, JHY, Kamaruddin, NH, Sim, GJH, Lapperre, TS, Koh, MS, Hui, DSC, Abisheganaden, JA, Tee, A, Tsaneva-Atanasova, K & Chotirmall, SH 2020, '"High-Risk" Clinical and Inflammatory Clusters in COPD of Chinese Descent', Chest, bind 158, nr. 1, s. 145-156. https://doi.org/10.1016/j.chest.2020.01.043

APA

Tiew, P. Y., Ko, F. W. S., Narayana, J. K., Poh, M. E., Xu, H., Neo, H. Y., Loh, L-C., Ong, C. K., Mac Aogáin, M., Tan, J. H. Y., Kamaruddin, N. H., Sim, G. J. H., Lapperre, T. S., Koh, M. S., Hui, D. S. C., Abisheganaden, J. A., Tee, A., Tsaneva-Atanasova, K., & Chotirmall, S. H. (2020). "High-Risk" Clinical and Inflammatory Clusters in COPD of Chinese Descent. Chest, 158(1), 145-156. https://doi.org/10.1016/j.chest.2020.01.043

Vancouver

Tiew PY, Ko FWS, Narayana JK, Poh ME, Xu H, Neo HY o.a. "High-Risk" Clinical and Inflammatory Clusters in COPD of Chinese Descent. Chest. 2020 jul.;158(1):145-156. https://doi.org/10.1016/j.chest.2020.01.043

Author

Tiew, Pei Yee ; Ko, Fanny Wai San ; Narayana, Jayanth Kumar ; Poh, Mau Ern ; Xu, Huiying ; Neo, Han Yee ; Loh, Li-Cher ; Ong, Choo Khoon ; Mac Aogáin, Micheál ; Tan, Jessica Han Ying ; Kamaruddin, Nabilah Husna ; Sim, Gerald Jiong Hui ; Lapperre, Therese S ; Koh, Mariko Siyue ; Hui, David Shu Cheong ; Abisheganaden, John Arputhan ; Tee, Augustine ; Tsaneva-Atanasova, Krasimira ; Chotirmall, Sanjay H. / "High-Risk" Clinical and Inflammatory Clusters in COPD of Chinese Descent. I: Chest. 2020 ; Bind 158, Nr. 1. s. 145-156.

Bibtex

@article{4633f1b6cc1f44529454ee9ec4416fc7,

title = "{"}High-Risk{"} Clinical and Inflammatory Clusters in COPD of Chinese Descent",

abstract = "BACKGROUND: COPD is a heterogeneous disease demonstrating inter-individual variation. A high COPD prevalence in Chinese populations is described, but little is known about disease clusters and prognostic outcomes in the Chinese population across Southeast Asia. We aim to determine if clusters of Chinese patients with COPD exist and their association with systemic inflammation and clinical outcomes.RESEARCH QUESTION: We aim to determine if clusters of Chinese patients with COPD exist and their association with clinical outcomes and inflammation.STUDY DESIGN AND METHODS: Chinese patients with stable COPD were prospectively recruited into two cohorts (derivation and validation) from six hospitals across three Southeast Asian countries (Singapore, Malaysia, and Hong Kong; n = 1,480). Each patient was followed more than 2 years. Clinical data (including co-morbidities) were employed in unsupervised hierarchical clustering (followed by validation) to determine the existence of patient clusters and their prognostic outcome. Accompanying systemic cytokine assessments were performed in a subset (n = 336) of patients with COPD to determine if inflammatory patterns and associated networks characterized the derived clusters.RESULTS: Five patient clusters were identified including: (1) ex-TB, (2) diabetic, (3) low comorbidity: low-risk, (4) low comorbidity: high-risk, and (5) cardiovascular. The cardiovascular and ex-TB clusters demonstrate highest mortality (independent of Global Initiative for Chronic Obstructive Lung Disease assessment) and illustrate diverse cytokine patterns with complex inflammatory networks.INTERPRETATION: We describe clusters of Chinese patients with COPD, two of which represent high-risk clusters. The cardiovascular and ex-TB patient clusters exhibit high mortality, significant inflammation, and complex cytokine networks. Clinical and inflammatory risk stratification of Chinese patients with COPD should be considered for targeted intervention to improve disease outcomes.",

author = "Tiew, {Pei Yee} and Ko, {Fanny Wai San} and Narayana, {Jayanth Kumar} and Poh, {Mau Ern} and Huiying Xu and Neo, {Han Yee} and Li-Cher Loh and Ong, {Choo Khoon} and {Mac Aog{\'a}in}, Miche{\'a}l and Tan, {Jessica Han Ying} and Kamaruddin, {Nabilah Husna} and Sim, {Gerald Jiong Hui} and Lapperre, {Therese S} and Koh, {Mariko Siyue} and Hui, {David Shu Cheong} and Abisheganaden, {John Arputhan} and Augustine Tee and Krasimira Tsaneva-Atanasova and Chotirmall, {Sanjay H}",

year = "2020",

month = jul,

doi = "10.1016/j.chest.2020.01.043",

language = "English",

volume = "158",

pages = "145--156",

journal = "Chest",

issn = "0012-3692",

publisher = "American College of Chest Physicians",

number = "1",

}

RIS

TY - JOUR

T1 - "High-Risk" Clinical and Inflammatory Clusters in COPD of Chinese Descent

AU - Tiew, Pei Yee

AU - Ko, Fanny Wai San

AU - Narayana, Jayanth Kumar

AU - Poh, Mau Ern

AU - Xu, Huiying

AU - Neo, Han Yee

AU - Loh, Li-Cher

AU - Ong, Choo Khoon

AU - Mac Aogáin, Micheál

AU - Tan, Jessica Han Ying

AU - Kamaruddin, Nabilah Husna

AU - Sim, Gerald Jiong Hui

AU - Lapperre, Therese S

AU - Koh, Mariko Siyue

AU - Hui, David Shu Cheong

AU - Abisheganaden, John Arputhan

AU - Tee, Augustine

AU - Tsaneva-Atanasova, Krasimira

AU - Chotirmall, Sanjay H

PY - 2020/7

Y1 - 2020/7

N2 - BACKGROUND: COPD is a heterogeneous disease demonstrating inter-individual variation. A high COPD prevalence in Chinese populations is described, but little is known about disease clusters and prognostic outcomes in the Chinese population across Southeast Asia. We aim to determine if clusters of Chinese patients with COPD exist and their association with systemic inflammation and clinical outcomes.RESEARCH QUESTION: We aim to determine if clusters of Chinese patients with COPD exist and their association with clinical outcomes and inflammation.STUDY DESIGN AND METHODS: Chinese patients with stable COPD were prospectively recruited into two cohorts (derivation and validation) from six hospitals across three Southeast Asian countries (Singapore, Malaysia, and Hong Kong; n = 1,480). Each patient was followed more than 2 years. Clinical data (including co-morbidities) were employed in unsupervised hierarchical clustering (followed by validation) to determine the existence of patient clusters and their prognostic outcome. Accompanying systemic cytokine assessments were performed in a subset (n = 336) of patients with COPD to determine if inflammatory patterns and associated networks characterized the derived clusters.RESULTS: Five patient clusters were identified including: (1) ex-TB, (2) diabetic, (3) low comorbidity: low-risk, (4) low comorbidity: high-risk, and (5) cardiovascular. The cardiovascular and ex-TB clusters demonstrate highest mortality (independent of Global Initiative for Chronic Obstructive Lung Disease assessment) and illustrate diverse cytokine patterns with complex inflammatory networks.INTERPRETATION: We describe clusters of Chinese patients with COPD, two of which represent high-risk clusters. The cardiovascular and ex-TB patient clusters exhibit high mortality, significant inflammation, and complex cytokine networks. Clinical and inflammatory risk stratification of Chinese patients with COPD should be considered for targeted intervention to improve disease outcomes.

AB - BACKGROUND: COPD is a heterogeneous disease demonstrating inter-individual variation. A high COPD prevalence in Chinese populations is described, but little is known about disease clusters and prognostic outcomes in the Chinese population across Southeast Asia. We aim to determine if clusters of Chinese patients with COPD exist and their association with systemic inflammation and clinical outcomes.RESEARCH QUESTION: We aim to determine if clusters of Chinese patients with COPD exist and their association with clinical outcomes and inflammation.STUDY DESIGN AND METHODS: Chinese patients with stable COPD were prospectively recruited into two cohorts (derivation and validation) from six hospitals across three Southeast Asian countries (Singapore, Malaysia, and Hong Kong; n = 1,480). Each patient was followed more than 2 years. Clinical data (including co-morbidities) were employed in unsupervised hierarchical clustering (followed by validation) to determine the existence of patient clusters and their prognostic outcome. Accompanying systemic cytokine assessments were performed in a subset (n = 336) of patients with COPD to determine if inflammatory patterns and associated networks characterized the derived clusters.RESULTS: Five patient clusters were identified including: (1) ex-TB, (2) diabetic, (3) low comorbidity: low-risk, (4) low comorbidity: high-risk, and (5) cardiovascular. The cardiovascular and ex-TB clusters demonstrate highest mortality (independent of Global Initiative for Chronic Obstructive Lung Disease assessment) and illustrate diverse cytokine patterns with complex inflammatory networks.INTERPRETATION: We describe clusters of Chinese patients with COPD, two of which represent high-risk clusters. The cardiovascular and ex-TB patient clusters exhibit high mortality, significant inflammation, and complex cytokine networks. Clinical and inflammatory risk stratification of Chinese patients with COPD should be considered for targeted intervention to improve disease outcomes.

U2 - 10.1016/j.chest.2020.01.043

DO - 10.1016/j.chest.2020.01.043

M3 - Journal article

C2 - 32092320

VL - 158

SP - 145

EP - 156

JO - Chest

JF - Chest

SN - 0012-3692

IS - 1

ER -

ID: 251937604

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