Hepatic-intestinal disposal of endogenous human alpha atrial natriuretic factor99-126 in patients with cirrhosis

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Standard

Hepatic-intestinal disposal of endogenous human alpha atrial natriuretic factor99-126 in patients with cirrhosis. / Henriksen, Jens Henrik Sahl; Bendtsen, F; Schütten, H J; Warberg, J.

I: American Journal of Gastroenterology, Bind 85, Nr. 9, 1990, s. 1155-9.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Henriksen, JHS, Bendtsen, F, Schütten, HJ & Warberg, J 1990, 'Hepatic-intestinal disposal of endogenous human alpha atrial natriuretic factor99-126 in patients with cirrhosis', American Journal of Gastroenterology, bind 85, nr. 9, s. 1155-9.

APA

Henriksen, J. H. S., Bendtsen, F., Schütten, H. J., & Warberg, J. (1990). Hepatic-intestinal disposal of endogenous human alpha atrial natriuretic factor99-126 in patients with cirrhosis. American Journal of Gastroenterology, 85(9), 1155-9.

Vancouver

Henriksen JHS, Bendtsen F, Schütten HJ, Warberg J. Hepatic-intestinal disposal of endogenous human alpha atrial natriuretic factor99-126 in patients with cirrhosis. American Journal of Gastroenterology. 1990;85(9):1155-9.

Author

Henriksen, Jens Henrik Sahl ; Bendtsen, F ; Schütten, H J ; Warberg, J. / Hepatic-intestinal disposal of endogenous human alpha atrial natriuretic factor99-126 in patients with cirrhosis. I: American Journal of Gastroenterology. 1990 ; Bind 85, Nr. 9. s. 1155-9.

Bibtex

@article{971385a0326c11df8ed1000ea68e967b,
title = "Hepatic-intestinal disposal of endogenous human alpha atrial natriuretic factor99-126 in patients with cirrhosis",
abstract = "Hepatic-intestinal disposal of endogenous human alpha atrial natriuretic factor99-126 (ANF) was assessed in 13 patients with cirrhosis (six Child-Turcotte class A, five class B, and two class C) and eight control subjects. The Fick principle was applied during hepatic vein catheterization. Arterial ANF concentration in patients with cirrhosis [11.1 +/- 1.6 (SEM) pmol/L] was not significantly different from that of the control subjects (14.9 +/- 4.2 pmol/L, NS). Arteriohepatic venous extraction ratio of ANF (0.43 +/- 0.05 in cirrhosis vs 0.37 +/- 0.09 in controls, NS), hepatic-intestinal clearance (274 +/- 46 vs 237 +/- 46 ml/min, NS) and removal rate (2.9 +/- 0.88 vs 3.1 +/- 0.77 pmol/min, NS) were closely similar in patients and controls. The present results give no indication that significantly reduced hepatic-intestinal disposal of ANF has a role in causing altered circulating plasma levels of this peptide in cirrhosis. This is in keeping with the presence of vascular clearance receptors and peptidases for ANF degradation independent of hepatocellular function.",
author = "Henriksen, {Jens Henrik Sahl} and F Bendtsen and Sch{\"u}tten, {H J} and J Warberg",
note = "Keywords: Adult; Aged; Atrial Natriuretic Factor; Catheterization; Female; Hemodynamics; Hepatic Veins; Humans; Liver Cirrhosis, Alcoholic; Male; Metabolic Clearance Rate; Middle Aged",
year = "1990",
language = "English",
volume = "85",
pages = "1155--9",
journal = "The American Journal of Gastroenterology",
issn = "0002-9270",
publisher = "nature publishing group",
number = "9",

}

RIS

TY - JOUR

T1 - Hepatic-intestinal disposal of endogenous human alpha atrial natriuretic factor99-126 in patients with cirrhosis

AU - Henriksen, Jens Henrik Sahl

AU - Bendtsen, F

AU - Schütten, H J

AU - Warberg, J

N1 - Keywords: Adult; Aged; Atrial Natriuretic Factor; Catheterization; Female; Hemodynamics; Hepatic Veins; Humans; Liver Cirrhosis, Alcoholic; Male; Metabolic Clearance Rate; Middle Aged

PY - 1990

Y1 - 1990

N2 - Hepatic-intestinal disposal of endogenous human alpha atrial natriuretic factor99-126 (ANF) was assessed in 13 patients with cirrhosis (six Child-Turcotte class A, five class B, and two class C) and eight control subjects. The Fick principle was applied during hepatic vein catheterization. Arterial ANF concentration in patients with cirrhosis [11.1 +/- 1.6 (SEM) pmol/L] was not significantly different from that of the control subjects (14.9 +/- 4.2 pmol/L, NS). Arteriohepatic venous extraction ratio of ANF (0.43 +/- 0.05 in cirrhosis vs 0.37 +/- 0.09 in controls, NS), hepatic-intestinal clearance (274 +/- 46 vs 237 +/- 46 ml/min, NS) and removal rate (2.9 +/- 0.88 vs 3.1 +/- 0.77 pmol/min, NS) were closely similar in patients and controls. The present results give no indication that significantly reduced hepatic-intestinal disposal of ANF has a role in causing altered circulating plasma levels of this peptide in cirrhosis. This is in keeping with the presence of vascular clearance receptors and peptidases for ANF degradation independent of hepatocellular function.

AB - Hepatic-intestinal disposal of endogenous human alpha atrial natriuretic factor99-126 (ANF) was assessed in 13 patients with cirrhosis (six Child-Turcotte class A, five class B, and two class C) and eight control subjects. The Fick principle was applied during hepatic vein catheterization. Arterial ANF concentration in patients with cirrhosis [11.1 +/- 1.6 (SEM) pmol/L] was not significantly different from that of the control subjects (14.9 +/- 4.2 pmol/L, NS). Arteriohepatic venous extraction ratio of ANF (0.43 +/- 0.05 in cirrhosis vs 0.37 +/- 0.09 in controls, NS), hepatic-intestinal clearance (274 +/- 46 vs 237 +/- 46 ml/min, NS) and removal rate (2.9 +/- 0.88 vs 3.1 +/- 0.77 pmol/min, NS) were closely similar in patients and controls. The present results give no indication that significantly reduced hepatic-intestinal disposal of ANF has a role in causing altered circulating plasma levels of this peptide in cirrhosis. This is in keeping with the presence of vascular clearance receptors and peptidases for ANF degradation independent of hepatocellular function.

M3 - Journal article

C2 - 2143885

VL - 85

SP - 1155

EP - 1159

JO - The American Journal of Gastroenterology

JF - The American Journal of Gastroenterology

SN - 0002-9270

IS - 9

ER -

ID: 18690465