Growth kinetics of four human breast carcinomas grown in nude mice

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Standard

Growth kinetics of four human breast carcinomas grown in nude mice. / Spang-Thomsen, M; Rygaard, K; Hansen, L; Halvorsen, A C; Vindeløv, L L; Brünner, N.

I: Breast Cancer Research and Treatment, Bind 14, Nr. 2, 1989, s. 235-43.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Spang-Thomsen, M, Rygaard, K, Hansen, L, Halvorsen, AC, Vindeløv, LL & Brünner, N 1989, 'Growth kinetics of four human breast carcinomas grown in nude mice', Breast Cancer Research and Treatment, bind 14, nr. 2, s. 235-43.

APA

Spang-Thomsen, M., Rygaard, K., Hansen, L., Halvorsen, A. C., Vindeløv, L. L., & Brünner, N. (1989). Growth kinetics of four human breast carcinomas grown in nude mice. Breast Cancer Research and Treatment, 14(2), 235-43.

Vancouver

Spang-Thomsen M, Rygaard K, Hansen L, Halvorsen AC, Vindeløv LL, Brünner N. Growth kinetics of four human breast carcinomas grown in nude mice. Breast Cancer Research and Treatment. 1989;14(2):235-43.

Author

Spang-Thomsen, M ; Rygaard, K ; Hansen, L ; Halvorsen, A C ; Vindeløv, L L ; Brünner, N. / Growth kinetics of four human breast carcinomas grown in nude mice. I: Breast Cancer Research and Treatment. 1989 ; Bind 14, Nr. 2. s. 235-43.

Bibtex

@article{32bad3a0654f11de8bc9000ea68e967b,
title = "Growth kinetics of four human breast carcinomas grown in nude mice",
abstract = "The immune-deficient nude mouse with human tumor xenografts is an appropriate model system for performing detailed growth kinetic examinations. In the present study one estrogen and progesterone receptor-negative (T60) and three receptor-positive (Br-10, MCF-7, T61) human breast cancer xenografts in nude mice were investigated. The proliferative tumor characteristics were examined by growth curves, thymidine labelling technique, and flow cytometric DNA analysis performed on fine-needle aspirations. The results showed that the tumors had growth kinetics comparable to other human tumor types with cell generation times of 42 to 60 hours. The three receptor-positive tumors had slower growth rate, larger tumor volume doubling time, and smaller growth fraction and labelling index than the receptor-negative tumor. However, no single proliferation parameter was sufficient to characterize the growth kinetics of individual tumors or to describe proliferative differences between the tumors.",
author = "M Spang-Thomsen and K Rygaard and L Hansen and Halvorsen, {A C} and Vindel{\o}v, {L L} and N Br{\"u}nner",
note = "Keywords: Animals; Breast Neoplasms; Cell Cycle; DNA, Neoplasm; Flow Cytometry; Humans; Mice; Mice, Nude; Mitotic Index; Neoplasm Transplantation; Receptors, Estrogen; Receptors, Progesterone; Tumor Cells, Cultured",
year = "1989",
language = "English",
volume = "14",
pages = "235--43",
journal = "Breast Cancer Research and Treatment",
issn = "0167-6806",
publisher = "Springer",
number = "2",

}

RIS

TY - JOUR

T1 - Growth kinetics of four human breast carcinomas grown in nude mice

AU - Spang-Thomsen, M

AU - Rygaard, K

AU - Hansen, L

AU - Halvorsen, A C

AU - Vindeløv, L L

AU - Brünner, N

N1 - Keywords: Animals; Breast Neoplasms; Cell Cycle; DNA, Neoplasm; Flow Cytometry; Humans; Mice; Mice, Nude; Mitotic Index; Neoplasm Transplantation; Receptors, Estrogen; Receptors, Progesterone; Tumor Cells, Cultured

PY - 1989

Y1 - 1989

N2 - The immune-deficient nude mouse with human tumor xenografts is an appropriate model system for performing detailed growth kinetic examinations. In the present study one estrogen and progesterone receptor-negative (T60) and three receptor-positive (Br-10, MCF-7, T61) human breast cancer xenografts in nude mice were investigated. The proliferative tumor characteristics were examined by growth curves, thymidine labelling technique, and flow cytometric DNA analysis performed on fine-needle aspirations. The results showed that the tumors had growth kinetics comparable to other human tumor types with cell generation times of 42 to 60 hours. The three receptor-positive tumors had slower growth rate, larger tumor volume doubling time, and smaller growth fraction and labelling index than the receptor-negative tumor. However, no single proliferation parameter was sufficient to characterize the growth kinetics of individual tumors or to describe proliferative differences between the tumors.

AB - The immune-deficient nude mouse with human tumor xenografts is an appropriate model system for performing detailed growth kinetic examinations. In the present study one estrogen and progesterone receptor-negative (T60) and three receptor-positive (Br-10, MCF-7, T61) human breast cancer xenografts in nude mice were investigated. The proliferative tumor characteristics were examined by growth curves, thymidine labelling technique, and flow cytometric DNA analysis performed on fine-needle aspirations. The results showed that the tumors had growth kinetics comparable to other human tumor types with cell generation times of 42 to 60 hours. The three receptor-positive tumors had slower growth rate, larger tumor volume doubling time, and smaller growth fraction and labelling index than the receptor-negative tumor. However, no single proliferation parameter was sufficient to characterize the growth kinetics of individual tumors or to describe proliferative differences between the tumors.

M3 - Journal article

C2 - 2605350

VL - 14

SP - 235

EP - 243

JO - Breast Cancer Research and Treatment

JF - Breast Cancer Research and Treatment

SN - 0167-6806

IS - 2

ER -

ID: 12870976