Glycine: a long-sought novel ligand for GPR158
Publikation: Bidrag til tidsskrift › Letter › Forskning › fagfællebedømt
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Glycine : a long-sought novel ligand for GPR158. / Rosenkilde, Mette Marie; Mathiesen, Jesper Mosolff.
I: Trends in Pharmacological Sciences, Bind 44, Nr. 8, 2023, s. 489-491.Publikation: Bidrag til tidsskrift › Letter › Forskning › fagfællebedømt
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TY - JOUR
T1 - Glycine
T2 - a long-sought novel ligand for GPR158
AU - Rosenkilde, Mette Marie
AU - Mathiesen, Jesper Mosolff
N1 - Publisher Copyright: © 2023 Elsevier Ltd
PY - 2023
Y1 - 2023
N2 - G-protein-coupled receptors (GPCRs) are important drug targets with chemically diverse ligands and varying intracellular coupling partners. Recent work by Laboute et al. deorphanized GPR158 as a metabotropic glycine receptor (mGlyR), thereby providing evidence of a novel neuromodulatory system involving this non-canonical Class C receptor with an impact on cognition and affective states.
AB - G-protein-coupled receptors (GPCRs) are important drug targets with chemically diverse ligands and varying intracellular coupling partners. Recent work by Laboute et al. deorphanized GPR158 as a metabotropic glycine receptor (mGlyR), thereby providing evidence of a novel neuromodulatory system involving this non-canonical Class C receptor with an impact on cognition and affective states.
KW - class C GPCRs
KW - glycine
KW - GPR158
KW - metabotropic receptor
U2 - 10.1016/j.tips.2023.05.004
DO - 10.1016/j.tips.2023.05.004
M3 - Letter
C2 - 37321907
AN - SCOPUS:85162846179
VL - 44
SP - 489
EP - 491
JO - Trends in Pharmacological Sciences
JF - Trends in Pharmacological Sciences
SN - 0165-6147
IS - 8
ER -
ID: 359041294