TY - JOUR

T1 - Genomic responses in rat cerebral cortex after traumatic brain injury

AU - von Gertten, Christina

AU - Flores Morales, Amilcar

AU - Holmin, Staffan

AU - Mathiesen, Tiit

AU - Nordqvist, Ann-Christin Sandberg

PY - 2005

Y1 - 2005

N2 - Traumatic brain injury (TBI) initiates a complex sequence of destructive and neuroprotective cellular responses. The initial mechanical injury is followed by an extended time period of secondary brain damage. Due to the complicated pathological picture a better understanding of the molecular events occurring during this secondary phase of injury is needed. This study was aimed at analysing gene expression patterns following cerebral cortical contusion in rat using high throughput microarray technology with the goal of identifying genes involved in an early and in a more delayed phase of trauma, as genomic responses behind secondary mechanisms likely are time-dependent.

AB - Traumatic brain injury (TBI) initiates a complex sequence of destructive and neuroprotective cellular responses. The initial mechanical injury is followed by an extended time period of secondary brain damage. Due to the complicated pathological picture a better understanding of the molecular events occurring during this secondary phase of injury is needed. This study was aimed at analysing gene expression patterns following cerebral cortical contusion in rat using high throughput microarray technology with the goal of identifying genes involved in an early and in a more delayed phase of trauma, as genomic responses behind secondary mechanisms likely are time-dependent.

U2 - 10.1186/1471-2202-6-69

DO - 10.1186/1471-2202-6-69

M3 - Journal article

C2 - 16318630

VL - 6

SP - 69

JO - B M C Neuroscience

JF - B M C Neuroscience

SN - 1471-2202

ER -