Gastric cancer risk in achlorhydric patients. A long-term follow-up study
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Gastric cancer risk in achlorhydric patients. A long-term follow-up study. / Svendsen, Jesper Hastrup; Dahl, C; Svendsen, L B; Christiansen, P M.
I: Scandinavian Journal of Gastroenterology, Bind 21, Nr. 1, 01.01.1986, s. 16-20.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Gastric cancer risk in achlorhydric patients. A long-term follow-up study
AU - Svendsen, Jesper Hastrup
AU - Dahl, C
AU - Svendsen, L B
AU - Christiansen, P M
PY - 1986/1/1
Y1 - 1986/1/1
N2 - Achlorhydria, determined by the augmented histamine test, is the functional expression of the most severe atrophic gastritis and is followed by a 4- to 6-fold increased risk of gastric cancer, as we found 5 cancers in 114 patients after a mean observation period of 8.4 years. The cancers developed from 1 to 17 years after achlorhydria diagnosis--three cases after more than 9 years. The study showed no difference in gastric cancer risk between patients with and without pernicious anaemia. Spontaneous achlorhydria is the late result of atrophic gastritis, which should be regarded the premalignant condition. The development of gastric cancer from pharmacologically reduced acid secretion must be regarded as highly hypothetical, since this is not followed by atrophic gastritis.
AB - Achlorhydria, determined by the augmented histamine test, is the functional expression of the most severe atrophic gastritis and is followed by a 4- to 6-fold increased risk of gastric cancer, as we found 5 cancers in 114 patients after a mean observation period of 8.4 years. The cancers developed from 1 to 17 years after achlorhydria diagnosis--three cases after more than 9 years. The study showed no difference in gastric cancer risk between patients with and without pernicious anaemia. Spontaneous achlorhydria is the late result of atrophic gastritis, which should be regarded the premalignant condition. The development of gastric cancer from pharmacologically reduced acid secretion must be regarded as highly hypothetical, since this is not followed by atrophic gastritis.
KW - Achlorhydria
KW - Adult
KW - Aged
KW - Denmark
KW - Female
KW - Follow-Up Studies
KW - Humans
KW - Male
KW - Middle Aged
KW - Risk
KW - Stomach Neoplasms
KW - Time Factors
M3 - Journal article
C2 - 3952447
VL - 21
SP - 16
EP - 20
JO - Scandinavian Journal of Gastroenterology
JF - Scandinavian Journal of Gastroenterology
SN - 0036-5521
IS - 1
ER -
ID: 32477339