Fetal biomarkers for lower urinary tract obstruction secondary to posterior urethral valves
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Fetal biomarkers for lower urinary tract obstruction secondary to posterior urethral valves. / Schanstra, Joost P.; Decramer, Stéphane; Buffin-Meyer, Bénédicte; Klein, Julie; Fossum, Magdalena; Wu, Hsi Yang.
I: Journal of Pediatric Urology, 2024.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Fetal biomarkers for lower urinary tract obstruction secondary to posterior urethral valves
AU - Schanstra, Joost P.
AU - Decramer, Stéphane
AU - Buffin-Meyer, Bénédicte
AU - Klein, Julie
AU - Fossum, Magdalena
AU - Wu, Hsi Yang
N1 - Publisher Copyright: © 2024 The Authors
PY - 2024
Y1 - 2024
N2 - Today, prenatal diagnosis of congenital urogenital malformations is mostly dependent on anatomical variations found on imaging. However, these findings can mislead us in telling us when to intervene, and about post-natal prognosis. Since many findings are dependent on multiple assessments, delayed diagnosis can occur, leading to less optimal outcomes compared to early intervention. Analyses of fetal urinary biomarkers have been proposed as a method of finding biological changes that are predictive for diagnosis and prognosis in fetuses at risk of kidney disease. We interviewed a group of researchers that have demonstrated that by combining multiple omics traits extracted from fetal urine, the biological variability found in single omics data can be circumvented. By analyzing multiple fetal urine peptides and metabolites at single time point, the prognostic power of postnatal renal outcome in fetuses with lower urinary tract obstruction is significantly increased. In this interview, we inquired about the technical aspects of the tests, challenges, and limitations the research group have come across, and how they envision the future for multi-omics fetal analysis in the clinic.
AB - Today, prenatal diagnosis of congenital urogenital malformations is mostly dependent on anatomical variations found on imaging. However, these findings can mislead us in telling us when to intervene, and about post-natal prognosis. Since many findings are dependent on multiple assessments, delayed diagnosis can occur, leading to less optimal outcomes compared to early intervention. Analyses of fetal urinary biomarkers have been proposed as a method of finding biological changes that are predictive for diagnosis and prognosis in fetuses at risk of kidney disease. We interviewed a group of researchers that have demonstrated that by combining multiple omics traits extracted from fetal urine, the biological variability found in single omics data can be circumvented. By analyzing multiple fetal urine peptides and metabolites at single time point, the prognostic power of postnatal renal outcome in fetuses with lower urinary tract obstruction is significantly increased. In this interview, we inquired about the technical aspects of the tests, challenges, and limitations the research group have come across, and how they envision the future for multi-omics fetal analysis in the clinic.
KW - Biomarkers
KW - Fetal medicine
KW - Obstructive kidney disease
KW - Pediatric urology
KW - Urethral Valves
KW - Urinary Peptides
U2 - 10.1016/j.jpurol.2024.01.011
DO - 10.1016/j.jpurol.2024.01.011
M3 - Review
C2 - 38280830
AN - SCOPUS:85185154931
JO - Journal of Pediatric Urology
JF - Journal of Pediatric Urology
SN - 1477-5131
ER -
ID: 386455158