Endurance training improves insulin sensitivity and body composition in prostate cancer patients treated with androgen deprivation therapy
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Endurance training improves insulin sensitivity and body composition in prostate cancer patients treated with androgen deprivation therapy. / Hvid, Thine; Winding, Kamilla; Rinnov, Anders; Dejgaard, Thomas Engel; Thomsen, Carsten; Iversen, Peter; Brasso, Klaus; Mikines, Kari J; van Hall, Gerrit; Lindegaard, Birgitte; Solomon, Thomas; Pedersen, Bente K.
I: Endocrine - Related Cancer, Bind 20, Nr. 5, 2013, s. 621-32.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Endurance training improves insulin sensitivity and body composition in prostate cancer patients treated with androgen deprivation therapy
AU - Hvid, Thine
AU - Winding, Kamilla
AU - Rinnov, Anders
AU - Dejgaard, Thomas Engel
AU - Thomsen, Carsten
AU - Iversen, Peter
AU - Brasso, Klaus
AU - Mikines, Kari J
AU - van Hall, Gerrit
AU - Lindegaard, Birgitte
AU - Solomon, Thomas
AU - Pedersen, Bente K
PY - 2013
Y1 - 2013
N2 - Insulin resistance and changes in body composition are side effects of androgen deprivation therapy (ADT) given to prostate cancer patients. The present study investigated whether endurance training improves insulin sensitivity and body composition in ADT-treated prostate cancer patients. Nine men undergoing ADT for prostate cancer and ten healthy men with normal testosterone levels underwent 12 weeks of endurance training. Primary endpoints were insulin sensitivity (euglycemic-hyperinsulinemic clamps with concomitant glucose-tracer infusion) and body composition (dual-energy X-ray absorptiometry and magnetic resonance imaging). The secondary endpoint was systemic inflammation. Statistical analysis was carried out using two-way ANOVA. Endurance training increased VO2max (ml(O2)/min per kg) by 11 and 13% in the patients and controls respectively (P
AB - Insulin resistance and changes in body composition are side effects of androgen deprivation therapy (ADT) given to prostate cancer patients. The present study investigated whether endurance training improves insulin sensitivity and body composition in ADT-treated prostate cancer patients. Nine men undergoing ADT for prostate cancer and ten healthy men with normal testosterone levels underwent 12 weeks of endurance training. Primary endpoints were insulin sensitivity (euglycemic-hyperinsulinemic clamps with concomitant glucose-tracer infusion) and body composition (dual-energy X-ray absorptiometry and magnetic resonance imaging). The secondary endpoint was systemic inflammation. Statistical analysis was carried out using two-way ANOVA. Endurance training increased VO2max (ml(O2)/min per kg) by 11 and 13% in the patients and controls respectively (P
U2 - 10.1530/ERC-12-0393
DO - 10.1530/ERC-12-0393
M3 - Journal article
C2 - 23744766
VL - 20
SP - 621
EP - 632
JO - Endocrine - Related Cancer
JF - Endocrine - Related Cancer
SN - 1351-0088
IS - 5
ER -
ID: 50217662