Effects of xenogeneic, allogeneic and isogeneic thymus grafts on lymphocyte populations in peripheral lymphoid organs of the nude rat

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Standard

Effects of xenogeneic, allogeneic and isogeneic thymus grafts on lymphocyte populations in peripheral lymphoid organs of the nude rat. / Hougen, H P; Klausen, B; Stenvang, J P; Kraemmer, J; Rygaard, J.

I: Laboratory Animals, Bind 21, Nr. 2, 04.1987, s. 103-11.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Hougen, HP, Klausen, B, Stenvang, JP, Kraemmer, J & Rygaard, J 1987, 'Effects of xenogeneic, allogeneic and isogeneic thymus grafts on lymphocyte populations in peripheral lymphoid organs of the nude rat', Laboratory Animals, bind 21, nr. 2, s. 103-11.

APA

Hougen, H. P., Klausen, B., Stenvang, J. P., Kraemmer, J., & Rygaard, J. (1987). Effects of xenogeneic, allogeneic and isogeneic thymus grafts on lymphocyte populations in peripheral lymphoid organs of the nude rat. Laboratory Animals, 21(2), 103-11.

Vancouver

Hougen HP, Klausen B, Stenvang JP, Kraemmer J, Rygaard J. Effects of xenogeneic, allogeneic and isogeneic thymus grafts on lymphocyte populations in peripheral lymphoid organs of the nude rat. Laboratory Animals. 1987 apr.;21(2):103-11.

Author

Hougen, H P ; Klausen, B ; Stenvang, J P ; Kraemmer, J ; Rygaard, J. / Effects of xenogeneic, allogeneic and isogeneic thymus grafts on lymphocyte populations in peripheral lymphoid organs of the nude rat. I: Laboratory Animals. 1987 ; Bind 21, Nr. 2. s. 103-11.

Bibtex

@article{9469db1ca3554604bf9686d2282d90a4,
title = "Effects of xenogeneic, allogeneic and isogeneic thymus grafts on lymphocyte populations in peripheral lymphoid organs of the nude rat",
abstract = "In order to gain information about the effect of xenografted, allografted and isografted thymic tissue on peripheral lymphoid organs of immune-deficient rats, athymic nude LEW rats of ninth backcross-intercross were grafted with fetal calf and neonatal BDIX and LEW thymus. Adrenalectomy was also performed in some animals in order to obtain a possible enhancement of the immunological reconstitution. Both groups of isogeneic-thymus-grafted animals had more T helper cells than the nude controls. Furthermore, they had more densely populated paracortical areas in the inguinal lymph nodes and higher lymphocyte counts in the thoracic duct lymph. Finally, the inguinal lymph nodes contained germinal centres. Xenogeneic and allogeneic thymus transplants did not induce constant changes in the parameters observed compared with the untreated nudes. No clear difference was observed between the adrenalectomized and non-adrenalectomized thymic-isografted animals. We therefore conclude that of all the experimental animals examined the isografted nude rats show by far the best response and that adrenalectomy seems unnecessary for the success of neonatal isogeneic thymus grafts. We also conclude that the isogeneic-thymus-grafted nude rat is a suitable tool for immunological reconstitution studies.",
keywords = "Adrenalectomy, Animals, Crosses, Genetic, Lymphocytes, Rats, Rats, Inbred Lew, Rats, Nude, Thymus Gland, Transplantation, Heterologous, Transplantation, Homologous, Transplantation, Isogeneic",
author = "Hougen, {H P} and B Klausen and Stenvang, {J P} and J Kraemmer and J Rygaard",
year = "1987",
month = apr,
language = "English",
volume = "21",
pages = "103--11",
journal = "Laboratory Animals",
issn = "0023-6772",
publisher = "SAGE Publications",
number = "2",

}

RIS

TY - JOUR

T1 - Effects of xenogeneic, allogeneic and isogeneic thymus grafts on lymphocyte populations in peripheral lymphoid organs of the nude rat

AU - Hougen, H P

AU - Klausen, B

AU - Stenvang, J P

AU - Kraemmer, J

AU - Rygaard, J

PY - 1987/4

Y1 - 1987/4

N2 - In order to gain information about the effect of xenografted, allografted and isografted thymic tissue on peripheral lymphoid organs of immune-deficient rats, athymic nude LEW rats of ninth backcross-intercross were grafted with fetal calf and neonatal BDIX and LEW thymus. Adrenalectomy was also performed in some animals in order to obtain a possible enhancement of the immunological reconstitution. Both groups of isogeneic-thymus-grafted animals had more T helper cells than the nude controls. Furthermore, they had more densely populated paracortical areas in the inguinal lymph nodes and higher lymphocyte counts in the thoracic duct lymph. Finally, the inguinal lymph nodes contained germinal centres. Xenogeneic and allogeneic thymus transplants did not induce constant changes in the parameters observed compared with the untreated nudes. No clear difference was observed between the adrenalectomized and non-adrenalectomized thymic-isografted animals. We therefore conclude that of all the experimental animals examined the isografted nude rats show by far the best response and that adrenalectomy seems unnecessary for the success of neonatal isogeneic thymus grafts. We also conclude that the isogeneic-thymus-grafted nude rat is a suitable tool for immunological reconstitution studies.

AB - In order to gain information about the effect of xenografted, allografted and isografted thymic tissue on peripheral lymphoid organs of immune-deficient rats, athymic nude LEW rats of ninth backcross-intercross were grafted with fetal calf and neonatal BDIX and LEW thymus. Adrenalectomy was also performed in some animals in order to obtain a possible enhancement of the immunological reconstitution. Both groups of isogeneic-thymus-grafted animals had more T helper cells than the nude controls. Furthermore, they had more densely populated paracortical areas in the inguinal lymph nodes and higher lymphocyte counts in the thoracic duct lymph. Finally, the inguinal lymph nodes contained germinal centres. Xenogeneic and allogeneic thymus transplants did not induce constant changes in the parameters observed compared with the untreated nudes. No clear difference was observed between the adrenalectomized and non-adrenalectomized thymic-isografted animals. We therefore conclude that of all the experimental animals examined the isografted nude rats show by far the best response and that adrenalectomy seems unnecessary for the success of neonatal isogeneic thymus grafts. We also conclude that the isogeneic-thymus-grafted nude rat is a suitable tool for immunological reconstitution studies.

KW - Adrenalectomy

KW - Animals

KW - Crosses, Genetic

KW - Lymphocytes

KW - Rats

KW - Rats, Inbred Lew

KW - Rats, Nude

KW - Thymus Gland

KW - Transplantation, Heterologous

KW - Transplantation, Homologous

KW - Transplantation, Isogeneic

M3 - Journal article

C2 - 3496487

VL - 21

SP - 103

EP - 111

JO - Laboratory Animals

JF - Laboratory Animals

SN - 0023-6772

IS - 2

ER -

ID: 44516282