Effect of intraarticular osmic acid on synovial membrane volume and inflammation, determined by magnetic resonance imaging.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning
Standard
Effect of intraarticular osmic acid on synovial membrane volume and inflammation, determined by magnetic resonance imaging. / Østergaard, Mikkel; Stoltenberg, M; Gideon, P; Wieslander, S; Sonne-Holm, Stig; Kryger, Peter; Sonne, M.
I: Scandinavian Journal of Rheumatology, Bind 24, Nr. 1, 1995, s. 5-12.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Effect of intraarticular osmic acid on synovial membrane volume and inflammation, determined by magnetic resonance imaging.
AU - Østergaard, Mikkel
AU - Stoltenberg, M
AU - Gideon, P
AU - Wieslander, S
AU - Sonne-Holm, Stig
AU - Kryger, Peter
AU - Sonne, M
PY - 1995
Y1 - 1995
N2 - The changes in MR-determined synovial membrane volume, early synovial enhancement, and cartilage and bone erosions after osmic acid knee synovectomy were studied. Gadolinium-DTPA enhanced magnetic resonance imaging (MRI) of 18 knees with persistent arthritis was performed before and 1 month after treatment. The synovial membrane volume was significantly reduced (median -52%) in all 9 patients brought into clinical remission (p < 0.01), while no significant change was found in patients with clinical relapse. The early synovial enhancement was not significantly changed. MRI revealed progressive erosive changes in 2 patients. The time of relapse was correlated to a MR-erosion score, but not to early synovial enhancement or volumes of synovium or effusion (Spearman tests). MRI-determined synovial membrane volumes and early synovial enhancement may be objective quantitative markers of inflammation. MR-scores of cartilage and bone erosions are sensitive to progressive changes occurring within a month.
AB - The changes in MR-determined synovial membrane volume, early synovial enhancement, and cartilage and bone erosions after osmic acid knee synovectomy were studied. Gadolinium-DTPA enhanced magnetic resonance imaging (MRI) of 18 knees with persistent arthritis was performed before and 1 month after treatment. The synovial membrane volume was significantly reduced (median -52%) in all 9 patients brought into clinical remission (p < 0.01), while no significant change was found in patients with clinical relapse. The early synovial enhancement was not significantly changed. MRI revealed progressive erosive changes in 2 patients. The time of relapse was correlated to a MR-erosion score, but not to early synovial enhancement or volumes of synovium or effusion (Spearman tests). MRI-determined synovial membrane volumes and early synovial enhancement may be objective quantitative markers of inflammation. MR-scores of cartilage and bone erosions are sensitive to progressive changes occurring within a month.
M3 - Journal article
VL - 24
SP - 5
EP - 12
JO - Scandinavian Journal of Rheumatology
JF - Scandinavian Journal of Rheumatology
SN - 0300-9742
IS - 1
ER -
ID: 34061749