Effect of cimetidine on survival after gastric cancer.
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Effect of cimetidine on survival after gastric cancer. / Tønnesen, H; Knigge, U; Bülow, Steffen; Damm, P; Fischerman, K; Hesselfeldt, Peter; Hjortrup, A; Pedersen, I K; Pedersen, V M; Siemssen, O J.
I: Lancet, Bind 2, Nr. 8618, 1988, s. 990-992.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning
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TY - JOUR
T1 - Effect of cimetidine on survival after gastric cancer.
AU - Tønnesen, H
AU - Knigge, U
AU - Bülow, Steffen
AU - Damm, P
AU - Fischerman, K
AU - Hesselfeldt, Peter
AU - Hjortrup, A
AU - Pedersen, I K
AU - Pedersen, V M
AU - Siemssen, O J
PY - 1988
Y1 - 1988
N2 - The effect of cimetidine on survival was investigated in 181 patients with gastric cancer. Immediately after operation or the decision not to operate, the patients were randomised in double-blind fashion to placebo or cimetidine 400 mg twice daily for two years or until death, with review every three months. Median survival in the cimetidine group was 450 days (range 1-1826) and in the placebo group 316 days (1-1653). The relative survival rates (cimetidine/placebo) were 45%/28% at 1 year, 22%/13% at 2 years, 13%/7% at 3 years, 9%/3% at 4 years, and 2%/0% at 5 years. Survival in the cimetidine group was significantly longer than in the placebo group.
AB - The effect of cimetidine on survival was investigated in 181 patients with gastric cancer. Immediately after operation or the decision not to operate, the patients were randomised in double-blind fashion to placebo or cimetidine 400 mg twice daily for two years or until death, with review every three months. Median survival in the cimetidine group was 450 days (range 1-1826) and in the placebo group 316 days (1-1653). The relative survival rates (cimetidine/placebo) were 45%/28% at 1 year, 22%/13% at 2 years, 13%/7% at 3 years, 9%/3% at 4 years, and 2%/0% at 5 years. Survival in the cimetidine group was significantly longer than in the placebo group.
M3 - Journal article
VL - 2
SP - 990
EP - 992
JO - The Lancet
JF - The Lancet
SN - 0140-6736
IS - 8618
ER -
ID: 34044693