Early systolic lengthening by speckle tracking echocardiography predicts outcome after coronary artery bypass surgery

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Standard

Early systolic lengthening by speckle tracking echocardiography predicts outcome after coronary artery bypass surgery. / Brainin, Philip; Lindberg, Søren; Olsen, Flemming J.; Pedersen, Sune; Iversen, Allan; Galatius, Søren; Fritz-Hansen, Thomas; Gislason, Gunnar; Søgaard, Peter; Møgelvang, Rasmus; Biering-Sørensen, Tor.

I: IJC Heart and Vasculature, Bind 34, 100799, 2021.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Brainin, P, Lindberg, S, Olsen, FJ, Pedersen, S, Iversen, A, Galatius, S, Fritz-Hansen, T, Gislason, G, Søgaard, P, Møgelvang, R & Biering-Sørensen, T 2021, 'Early systolic lengthening by speckle tracking echocardiography predicts outcome after coronary artery bypass surgery', IJC Heart and Vasculature, bind 34, 100799. https://doi.org/10.1016/j.ijcha.2021.100799

APA

Brainin, P., Lindberg, S., Olsen, F. J., Pedersen, S., Iversen, A., Galatius, S., Fritz-Hansen, T., Gislason, G., Søgaard, P., Møgelvang, R., & Biering-Sørensen, T. (2021). Early systolic lengthening by speckle tracking echocardiography predicts outcome after coronary artery bypass surgery. IJC Heart and Vasculature, 34, [100799]. https://doi.org/10.1016/j.ijcha.2021.100799

Vancouver

Brainin P, Lindberg S, Olsen FJ, Pedersen S, Iversen A, Galatius S o.a. Early systolic lengthening by speckle tracking echocardiography predicts outcome after coronary artery bypass surgery. IJC Heart and Vasculature. 2021;34. 100799. https://doi.org/10.1016/j.ijcha.2021.100799

Author

Brainin, Philip ; Lindberg, Søren ; Olsen, Flemming J. ; Pedersen, Sune ; Iversen, Allan ; Galatius, Søren ; Fritz-Hansen, Thomas ; Gislason, Gunnar ; Søgaard, Peter ; Møgelvang, Rasmus ; Biering-Sørensen, Tor. / Early systolic lengthening by speckle tracking echocardiography predicts outcome after coronary artery bypass surgery. I: IJC Heart and Vasculature. 2021 ; Bind 34.

Bibtex

@article{ac3c9aef2e444f6bb1bc709680e8c684,
title = "Early systolic lengthening by speckle tracking echocardiography predicts outcome after coronary artery bypass surgery",
abstract = "Background: Early systolic lengthening (ESL), a paradoxical stretch of myocardial fibers, has been linked to loss of myocardial viability and contractile dysfunction. We assessed the long-term prognostic potential of ESL in coronary artery bypass graft (CABG) patients. Methods: We retrospectively included patients (n = 709; mean age 68 years; 85% men) who underwent speckle tracking echocardiography (median 15 days) prior to CABG. Endpoints were cardiovascular death (CVD) and all-cause mortality. We assessed amplitude of ESL (%), defined as peak positive strain, and duration of ESL (ms), determined as time from Q-wave on the ECG to peak positive strain. We applied Cox models adjusted for clinical risk assessed as EuroSCORE II. Results: During median follow-up of 3.8 years [IQR 2.7–4.9 years], 45 (6%) experienced CVD and 80 (11%) died. In survival analyses adjusted for EuroSCORE II, each 1% increase in amplitude of ESL was associated with CVD (HR 1.35 [95%CI 1.09–1.68], P = 0.006) and all-cause mortality (HR 1.29 [95%CI 1.08–1.54], P = 0.004). Similar findings applied to duration of ESL (per 10ms increase) and CVD (HR 1.12 [95%CI 1.02–1.23], P = 0.016) and all-cause mortality (HR 1.09 [95%CI 1.01––1.17], P = 0.031). The prognostic value of ESL amplitude was modified by sex (P interaction < 0.05), such that the prognostic value was greater in women for both endpoints. When adding ESL duration to EuroSCORE II, the net reclassification index improved significantly for both CVD and all-cause mortality. Conclusions: Assessment of ESL provides independent and incremental prognostic information in addition to the EuroSCORE II for CVD and all-cause mortality in CABG patients.",
keywords = "Deformation, Prognosis, Revascularization, Systolic lengthening",
author = "Philip Brainin and S{\o}ren Lindberg and Olsen, {Flemming J.} and Sune Pedersen and Allan Iversen and S{\o}ren Galatius and Thomas Fritz-Hansen and Gunnar Gislason and Peter S{\o}gaard and Rasmus M{\o}gelvang and Tor Biering-S{\o}rensen",
note = "Publisher Copyright: {\textcopyright} 2021 The Authors",
year = "2021",
doi = "10.1016/j.ijcha.2021.100799",
language = "English",
volume = "34",
journal = "IJC Heart and Vasculature",
issn = "2352-9067",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Early systolic lengthening by speckle tracking echocardiography predicts outcome after coronary artery bypass surgery

AU - Brainin, Philip

AU - Lindberg, Søren

AU - Olsen, Flemming J.

AU - Pedersen, Sune

AU - Iversen, Allan

AU - Galatius, Søren

AU - Fritz-Hansen, Thomas

AU - Gislason, Gunnar

AU - Søgaard, Peter

AU - Møgelvang, Rasmus

AU - Biering-Sørensen, Tor

N1 - Publisher Copyright: © 2021 The Authors

PY - 2021

Y1 - 2021

N2 - Background: Early systolic lengthening (ESL), a paradoxical stretch of myocardial fibers, has been linked to loss of myocardial viability and contractile dysfunction. We assessed the long-term prognostic potential of ESL in coronary artery bypass graft (CABG) patients. Methods: We retrospectively included patients (n = 709; mean age 68 years; 85% men) who underwent speckle tracking echocardiography (median 15 days) prior to CABG. Endpoints were cardiovascular death (CVD) and all-cause mortality. We assessed amplitude of ESL (%), defined as peak positive strain, and duration of ESL (ms), determined as time from Q-wave on the ECG to peak positive strain. We applied Cox models adjusted for clinical risk assessed as EuroSCORE II. Results: During median follow-up of 3.8 years [IQR 2.7–4.9 years], 45 (6%) experienced CVD and 80 (11%) died. In survival analyses adjusted for EuroSCORE II, each 1% increase in amplitude of ESL was associated with CVD (HR 1.35 [95%CI 1.09–1.68], P = 0.006) and all-cause mortality (HR 1.29 [95%CI 1.08–1.54], P = 0.004). Similar findings applied to duration of ESL (per 10ms increase) and CVD (HR 1.12 [95%CI 1.02–1.23], P = 0.016) and all-cause mortality (HR 1.09 [95%CI 1.01––1.17], P = 0.031). The prognostic value of ESL amplitude was modified by sex (P interaction < 0.05), such that the prognostic value was greater in women for both endpoints. When adding ESL duration to EuroSCORE II, the net reclassification index improved significantly for both CVD and all-cause mortality. Conclusions: Assessment of ESL provides independent and incremental prognostic information in addition to the EuroSCORE II for CVD and all-cause mortality in CABG patients.

AB - Background: Early systolic lengthening (ESL), a paradoxical stretch of myocardial fibers, has been linked to loss of myocardial viability and contractile dysfunction. We assessed the long-term prognostic potential of ESL in coronary artery bypass graft (CABG) patients. Methods: We retrospectively included patients (n = 709; mean age 68 years; 85% men) who underwent speckle tracking echocardiography (median 15 days) prior to CABG. Endpoints were cardiovascular death (CVD) and all-cause mortality. We assessed amplitude of ESL (%), defined as peak positive strain, and duration of ESL (ms), determined as time from Q-wave on the ECG to peak positive strain. We applied Cox models adjusted for clinical risk assessed as EuroSCORE II. Results: During median follow-up of 3.8 years [IQR 2.7–4.9 years], 45 (6%) experienced CVD and 80 (11%) died. In survival analyses adjusted for EuroSCORE II, each 1% increase in amplitude of ESL was associated with CVD (HR 1.35 [95%CI 1.09–1.68], P = 0.006) and all-cause mortality (HR 1.29 [95%CI 1.08–1.54], P = 0.004). Similar findings applied to duration of ESL (per 10ms increase) and CVD (HR 1.12 [95%CI 1.02–1.23], P = 0.016) and all-cause mortality (HR 1.09 [95%CI 1.01––1.17], P = 0.031). The prognostic value of ESL amplitude was modified by sex (P interaction < 0.05), such that the prognostic value was greater in women for both endpoints. When adding ESL duration to EuroSCORE II, the net reclassification index improved significantly for both CVD and all-cause mortality. Conclusions: Assessment of ESL provides independent and incremental prognostic information in addition to the EuroSCORE II for CVD and all-cause mortality in CABG patients.

KW - Deformation

KW - Prognosis

KW - Revascularization

KW - Systolic lengthening

U2 - 10.1016/j.ijcha.2021.100799

DO - 10.1016/j.ijcha.2021.100799

M3 - Journal article

C2 - 34124339

AN - SCOPUS:85107864606

VL - 34

JO - IJC Heart and Vasculature

JF - IJC Heart and Vasculature

SN - 2352-9067

M1 - 100799

ER -

ID: 273646833