Dynamics of nephron-vascular network
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Dynamics of nephron-vascular network. / Postnov, Dmitry; Postnov, D E; Marsh, D J; von Holstein-Rathlou, Niels-Henrik; Sosnovtseva, Olga.
I: Bulletin of Mathematical Biology, Bind 74, Nr. 12, 2012, s. 2820-41.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Dynamics of nephron-vascular network
AU - Postnov, Dmitry
AU - Postnov, D E
AU - Marsh, D J
AU - von Holstein-Rathlou, Niels-Henrik
AU - Sosnovtseva, Olga
PY - 2012
Y1 - 2012
N2 - The paper presents a modeling study of the spatial dynamics of a nephro-vascular network consisting of individual nephrons connected via a tree-like vascular branching structure. We focus on the effects of nonlinear mechanisms that are responsible for the formation of synchronous patterns in order to learn about processes not directly amenable to experimentation. We demonstrate that: (i) the nearest nephrons are synchronized in-phase due to a vascular propagated electrical coupling, (ii) the next few branching levels display a formation of phase-shifted patterns due to hemodynamic coupling and mode elimination, and (iii) distantly located areas show asynchronous behavior or, if all nephrons and branches are perfectly identical, an infinitely long transient behavior. These results contribute to the understanding of mechanisms responsible for the highly dynamic and limited synchronization observed among groups of nephrons despite of the fairly strong interaction between the individual units.
AB - The paper presents a modeling study of the spatial dynamics of a nephro-vascular network consisting of individual nephrons connected via a tree-like vascular branching structure. We focus on the effects of nonlinear mechanisms that are responsible for the formation of synchronous patterns in order to learn about processes not directly amenable to experimentation. We demonstrate that: (i) the nearest nephrons are synchronized in-phase due to a vascular propagated electrical coupling, (ii) the next few branching levels display a formation of phase-shifted patterns due to hemodynamic coupling and mode elimination, and (iii) distantly located areas show asynchronous behavior or, if all nephrons and branches are perfectly identical, an infinitely long transient behavior. These results contribute to the understanding of mechanisms responsible for the highly dynamic and limited synchronization observed among groups of nephrons despite of the fairly strong interaction between the individual units.
U2 - 10.1007/s11538-012-9781-6
DO - 10.1007/s11538-012-9781-6
M3 - Journal article
C2 - 23081729
VL - 74
SP - 2820
EP - 2841
JO - Bulletin of Mathematical Biology
JF - Bulletin of Mathematical Biology
SN - 0092-8240
IS - 12
ER -
ID: 41983112