Does the release of potassium from astrocyte endfeet regulate cerebral blood flow?

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

Does the release of potassium from astrocyte endfeet regulate cerebral blood flow? / Paulson, O B; Newman, E A.

I: Science (New York, N.Y.), Bind 237, Nr. 4817, 21.08.1987, s. 896-8.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Paulson, OB & Newman, EA 1987, 'Does the release of potassium from astrocyte endfeet regulate cerebral blood flow?', Science (New York, N.Y.), bind 237, nr. 4817, s. 896-8. https://doi.org/10.1126/science.3616619

APA

Paulson, O. B., & Newman, E. A. (1987). Does the release of potassium from astrocyte endfeet regulate cerebral blood flow? Science (New York, N.Y.), 237(4817), 896-8. https://doi.org/10.1126/science.3616619

Vancouver

Paulson OB, Newman EA. Does the release of potassium from astrocyte endfeet regulate cerebral blood flow? Science (New York, N.Y.). 1987 aug. 21;237(4817):896-8. https://doi.org/10.1126/science.3616619

Author

Paulson, O B ; Newman, E A. / Does the release of potassium from astrocyte endfeet regulate cerebral blood flow?. I: Science (New York, N.Y.). 1987 ; Bind 237, Nr. 4817. s. 896-8.

Bibtex

@article{727d370007944df789f90f3a432fe281,
title = "Does the release of potassium from astrocyte endfeet regulate cerebral blood flow?",
abstract = "Local increases in neuronal activity within the brain lead to dilation of blood vessels and to increased regional cerebral blood flow. Increases in extracellular potassium concentration are known to dilate cerebral arterioles. Recent studies have suggested that the potassium released by active neurons is transported through astrocytic glial cells and released from their endfeet onto blood vessels. The results of computer simulations of potassium dynamics in the brain indicate that the release of potassium from astrocyte endfeet raises perivascular potassium concentration much more rapidly and to higher levels than does diffusion of potassium through extracellular space, particularly when the site of a potassium increase is some distance from the vessel wall. On the basis of this finding, it is proposed that the release of potassium from astrocyte endfeet plays an important role in regulating regional cerebral blood flow in response to changes in neuronal activity.",
keywords = "Arteries/innervation, Arterioles/innervation, Astrocytes/physiology, Cerebrovascular Circulation, Computer Simulation, Potassium/physiology, Regional Blood Flow",
author = "Paulson, {O B} and Newman, {E A}",
year = "1987",
month = aug,
day = "21",
doi = "10.1126/science.3616619",
language = "English",
volume = "237",
pages = "896--8",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "4817",

}

RIS

TY - JOUR

T1 - Does the release of potassium from astrocyte endfeet regulate cerebral blood flow?

AU - Paulson, O B

AU - Newman, E A

PY - 1987/8/21

Y1 - 1987/8/21

N2 - Local increases in neuronal activity within the brain lead to dilation of blood vessels and to increased regional cerebral blood flow. Increases in extracellular potassium concentration are known to dilate cerebral arterioles. Recent studies have suggested that the potassium released by active neurons is transported through astrocytic glial cells and released from their endfeet onto blood vessels. The results of computer simulations of potassium dynamics in the brain indicate that the release of potassium from astrocyte endfeet raises perivascular potassium concentration much more rapidly and to higher levels than does diffusion of potassium through extracellular space, particularly when the site of a potassium increase is some distance from the vessel wall. On the basis of this finding, it is proposed that the release of potassium from astrocyte endfeet plays an important role in regulating regional cerebral blood flow in response to changes in neuronal activity.

AB - Local increases in neuronal activity within the brain lead to dilation of blood vessels and to increased regional cerebral blood flow. Increases in extracellular potassium concentration are known to dilate cerebral arterioles. Recent studies have suggested that the potassium released by active neurons is transported through astrocytic glial cells and released from their endfeet onto blood vessels. The results of computer simulations of potassium dynamics in the brain indicate that the release of potassium from astrocyte endfeet raises perivascular potassium concentration much more rapidly and to higher levels than does diffusion of potassium through extracellular space, particularly when the site of a potassium increase is some distance from the vessel wall. On the basis of this finding, it is proposed that the release of potassium from astrocyte endfeet plays an important role in regulating regional cerebral blood flow in response to changes in neuronal activity.

KW - Arteries/innervation

KW - Arterioles/innervation

KW - Astrocytes/physiology

KW - Cerebrovascular Circulation

KW - Computer Simulation

KW - Potassium/physiology

KW - Regional Blood Flow

U2 - 10.1126/science.3616619

DO - 10.1126/science.3616619

M3 - Journal article

C2 - 3616619

VL - 237

SP - 896

EP - 898

JO - Science

JF - Science

SN - 0036-8075

IS - 4817

ER -

ID: 275604607