Differential effect of continuous administration of beta‐adrenoceptor antagonists on antipyrine and phenytoin clearance
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Differential effect of continuous administration of beta‐adrenoceptor antagonists on antipyrine and phenytoin clearance. / Perrild, H.; Kayser, L.; Poulsen, H.E.; Skovsted, L.; Jørgensen, B.; Hansen, J.M.
I: British Journal of Clinical Pharmacology, Bind 28, Nr. 5, 1989, s. 551-554.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Differential effect of continuous administration of beta‐adrenoceptor antagonists on antipyrine and phenytoin clearance
AU - Perrild, H.
AU - Kayser, L.
AU - Poulsen, H.E.
AU - Skovsted, L.
AU - Jørgensen, B.
AU - Hansen, J.M.
PY - 1989
Y1 - 1989
N2 - 1. Antipyrine (1000 mg orally) clearance was studied 3 days before treatment with either atenolol (50 mg twice daily), metoprolol (100 mg twice daily), propranolol (80 mg twice daily) or placebo, and at day 5 and 18 during treatment. Phenytoin (100 mg intravenously) clearance was measured on days 0, 7 and 21 during treatment. 2. Antipyrine clearance was decreased by about 20% after 5 days of treatment with either propranolol or atenolol and this decrease persisted after 18 days of treatment. Antipyrine clearance did not change during treatment with either metoprolol or placebo. Phenytoin clearance did not change during any of the treatments. 1989 The British Pharmacological Society
AB - 1. Antipyrine (1000 mg orally) clearance was studied 3 days before treatment with either atenolol (50 mg twice daily), metoprolol (100 mg twice daily), propranolol (80 mg twice daily) or placebo, and at day 5 and 18 during treatment. Phenytoin (100 mg intravenously) clearance was measured on days 0, 7 and 21 during treatment. 2. Antipyrine clearance was decreased by about 20% after 5 days of treatment with either propranolol or atenolol and this decrease persisted after 18 days of treatment. Antipyrine clearance did not change during treatment with either metoprolol or placebo. Phenytoin clearance did not change during any of the treatments. 1989 The British Pharmacological Society
U2 - 10.1111/j.1365-2125.1989.tb03541.x
DO - 10.1111/j.1365-2125.1989.tb03541.x
M3 - Journal article
C2 - 2574053
AN - SCOPUS:0024454805
VL - 28
SP - 551
EP - 554
JO - British Journal of Clinical Pharmacology, Supplement
JF - British Journal of Clinical Pharmacology, Supplement
SN - 0264-3774
IS - 5
ER -
ID: 335355756