Danish Nationwide Study on Surgical Treatment of Infective Native Abdominal Aortic Aneurysms
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Danish Nationwide Study on Surgical Treatment of Infective Native Abdominal Aortic Aneurysms. / Skov, Rebecca A.C.; Lawaetz, Martin; Eldrup, Nikolaj; Resch, Timothy A.; Sörelius, Karl; Houlind, Kim; Lindholt, Jes; Bloksgaard, Kristian Aldrup; Hansen, Allan Kornmaaler; Rudolph, Claudina; Budtz-Lilly, Jacob; Shahidi, Saeid; Høgh, Annette; the Danish Academic Research Consortium for INAAs.
I: European Journal of Vascular and Endovascular Surgery, 2024.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Danish Nationwide Study on Surgical Treatment of Infective Native Abdominal Aortic Aneurysms
AU - Skov, Rebecca A.C.
AU - Lawaetz, Martin
AU - Eldrup, Nikolaj
AU - Resch, Timothy A.
AU - Sörelius, Karl
AU - Houlind, Kim
AU - Lindholt, Jes
AU - Bloksgaard, Kristian Aldrup
AU - Hansen, Allan Kornmaaler
AU - Rudolph, Claudina
AU - Budtz-Lilly, Jacob
AU - Shahidi, Saeid
AU - Høgh, Annette
AU - the Danish Academic Research Consortium for INAAs
N1 - Publisher Copyright: © 2023 The Author(s)
PY - 2024
Y1 - 2024
N2 - Objective: This study aimed to describe surgical trends, survival, and infection related complications (IRC) in a Danish cohort of patients with infective native aortic aneurysms (INAAs). Methods: A retrospective nationwide cohort study including all patients in Denmark who were surgically treated for abdominal INAA between 2000 and 2020 was conducted. Patients were identified through the Danish vascular registry, Karbase, which is a database registering all patients treated with vascular surgery in Denmark. Subsequent data on clinical presentation, treatment, all cause mortality, and complications were obtained from the electronic patient charts. Results: Seventy-five patients were included in the study, of whom 60 (80%) were male, with a median age of 69 (IQR 64, 75) years. Open surgical repair (OSR) was performed in 54 (72%) patients and endovascular aortic repair (EVAR) in 21 (28%). Median follow up was 52 (IQR 32, 103) months. Open repair was consistently the most frequent treatment modality throughout the study period, but EVAR became more frequent over time. The 30 day survival of the total cohort was 97% (94 – 100%). Kaplan–Meier survival estimates for the cohort were 92% (95% CI 85 – 98%), 80% (95% CI 71 – 91%), 63% (95% CI 52 – 78%), and 48% (95% CI 35 – 66%) at one, three, five and 10 years, respectively. Patients treated by EVAR had comparable long term survival to patients treated by OSR, with a hazard ratio of 0.35 (95% CI 0.10 – 1.22), but was associated with better short term survival up to five years. The most common cause of death was sepsis. Five (9%) OSR patients had IRC compared with one (5%) EVAR patient. Conclusion: In this nationwide study of patients treated for abdominal INAA, an increasing number of patients were surgically treated during the study period. Patients treated by EVAR demonstrated long term survival comparable to OSR. The incidence of post-operative IRC was low. These results should be interpreted with caution and prospective registries are needed.
AB - Objective: This study aimed to describe surgical trends, survival, and infection related complications (IRC) in a Danish cohort of patients with infective native aortic aneurysms (INAAs). Methods: A retrospective nationwide cohort study including all patients in Denmark who were surgically treated for abdominal INAA between 2000 and 2020 was conducted. Patients were identified through the Danish vascular registry, Karbase, which is a database registering all patients treated with vascular surgery in Denmark. Subsequent data on clinical presentation, treatment, all cause mortality, and complications were obtained from the electronic patient charts. Results: Seventy-five patients were included in the study, of whom 60 (80%) were male, with a median age of 69 (IQR 64, 75) years. Open surgical repair (OSR) was performed in 54 (72%) patients and endovascular aortic repair (EVAR) in 21 (28%). Median follow up was 52 (IQR 32, 103) months. Open repair was consistently the most frequent treatment modality throughout the study period, but EVAR became more frequent over time. The 30 day survival of the total cohort was 97% (94 – 100%). Kaplan–Meier survival estimates for the cohort were 92% (95% CI 85 – 98%), 80% (95% CI 71 – 91%), 63% (95% CI 52 – 78%), and 48% (95% CI 35 – 66%) at one, three, five and 10 years, respectively. Patients treated by EVAR had comparable long term survival to patients treated by OSR, with a hazard ratio of 0.35 (95% CI 0.10 – 1.22), but was associated with better short term survival up to five years. The most common cause of death was sepsis. Five (9%) OSR patients had IRC compared with one (5%) EVAR patient. Conclusion: In this nationwide study of patients treated for abdominal INAA, an increasing number of patients were surgically treated during the study period. Patients treated by EVAR demonstrated long term survival comparable to OSR. The incidence of post-operative IRC was low. These results should be interpreted with caution and prospective registries are needed.
KW - Complications
KW - Endovascular repair
KW - Infective native aortic aneurysm
KW - Mycotic aneurysm
KW - Open repair
KW - Survival
U2 - 10.1016/j.ejvs.2023.11.006
DO - 10.1016/j.ejvs.2023.11.006
M3 - Journal article
C2 - 37944790
AN - SCOPUS:85184077158
JO - European Journal of Vascular and Endovascular Surgery
JF - European Journal of Vascular and Endovascular Surgery
SN - 1078-5884
ER -
ID: 383746007