Cortisol secretion in patients with normoprolactinemic amenorrhea

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Standard

Cortisol secretion in patients with normoprolactinemic amenorrhea. / Boesgaard, S; Hagen, C; Andersen, A N; Djursing, H; Fenger, M.

I: Acta Endocrinologica (Copenh), Bind 118, Nr. 4, 1988, s. 544-50.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Boesgaard, S, Hagen, C, Andersen, AN, Djursing, H & Fenger, M 1988, 'Cortisol secretion in patients with normoprolactinemic amenorrhea', Acta Endocrinologica (Copenh), bind 118, nr. 4, s. 544-50.

APA

Boesgaard, S., Hagen, C., Andersen, A. N., Djursing, H., & Fenger, M. (1988). Cortisol secretion in patients with normoprolactinemic amenorrhea. Acta Endocrinologica (Copenh), 118(4), 544-50.

Vancouver

Boesgaard S, Hagen C, Andersen AN, Djursing H, Fenger M. Cortisol secretion in patients with normoprolactinemic amenorrhea. Acta Endocrinologica (Copenh). 1988;118(4):544-50.

Author

Boesgaard, S ; Hagen, C ; Andersen, A N ; Djursing, H ; Fenger, M. / Cortisol secretion in patients with normoprolactinemic amenorrhea. I: Acta Endocrinologica (Copenh). 1988 ; Bind 118, Nr. 4. s. 544-50.

Bibtex

@article{134d3ee0e5394c2d82582f2840a53a77,
title = "Cortisol secretion in patients with normoprolactinemic amenorrhea",
abstract = "Patients with functional amenorrhea have raised central dopaminergic activity and opioid-mediated GnRH inhibition leading to inhibition of hypothalamic-pituitary-ovarian function. In the present study, basal serum cortisol and ACTH levels were measured in normoprolactinemic amenorrheic patients with (N = 14) and without (N = 7) insulin-dependent diabetes mellitus. Basal serum cortisol levels was significantly (P less than 0.01) elevated in patients with normoprolactinemic amenorrhea compared with normal women. Basal serum cortisol was significantly (P less than 0.02) elevated in amenorrheic diabetic patients compared with menstruating diabetic women. In the amenorrheic groups both cortisol and ACTH levels increased significantly (P less than 0.01) after dopamine D-2 receptor blockade, whereas no hormonal changes occurred in the control groups. It is concluded that patients with normoprolactinemic amenorrhea have elevated basal serum cortisol, the reason probably being hypersecretion of corticotropin-releasing hormone. Secondly that dopaminergic blockade with metoclopramide stimulates ACTH and cortisol secretion in patients presumed to have raised dopaminergic activity.",
author = "S Boesgaard and C Hagen and Andersen, {A N} and H Djursing and M Fenger",
year = "1988",
language = "English",
volume = "118",
pages = "544--50",
journal = "Acta Endocrinologica (Copenh)",
number = "4",

}

RIS

TY - JOUR

T1 - Cortisol secretion in patients with normoprolactinemic amenorrhea

AU - Boesgaard, S

AU - Hagen, C

AU - Andersen, A N

AU - Djursing, H

AU - Fenger, M

PY - 1988

Y1 - 1988

N2 - Patients with functional amenorrhea have raised central dopaminergic activity and opioid-mediated GnRH inhibition leading to inhibition of hypothalamic-pituitary-ovarian function. In the present study, basal serum cortisol and ACTH levels were measured in normoprolactinemic amenorrheic patients with (N = 14) and without (N = 7) insulin-dependent diabetes mellitus. Basal serum cortisol levels was significantly (P less than 0.01) elevated in patients with normoprolactinemic amenorrhea compared with normal women. Basal serum cortisol was significantly (P less than 0.02) elevated in amenorrheic diabetic patients compared with menstruating diabetic women. In the amenorrheic groups both cortisol and ACTH levels increased significantly (P less than 0.01) after dopamine D-2 receptor blockade, whereas no hormonal changes occurred in the control groups. It is concluded that patients with normoprolactinemic amenorrhea have elevated basal serum cortisol, the reason probably being hypersecretion of corticotropin-releasing hormone. Secondly that dopaminergic blockade with metoclopramide stimulates ACTH and cortisol secretion in patients presumed to have raised dopaminergic activity.

AB - Patients with functional amenorrhea have raised central dopaminergic activity and opioid-mediated GnRH inhibition leading to inhibition of hypothalamic-pituitary-ovarian function. In the present study, basal serum cortisol and ACTH levels were measured in normoprolactinemic amenorrheic patients with (N = 14) and without (N = 7) insulin-dependent diabetes mellitus. Basal serum cortisol levels was significantly (P less than 0.01) elevated in patients with normoprolactinemic amenorrhea compared with normal women. Basal serum cortisol was significantly (P less than 0.02) elevated in amenorrheic diabetic patients compared with menstruating diabetic women. In the amenorrheic groups both cortisol and ACTH levels increased significantly (P less than 0.01) after dopamine D-2 receptor blockade, whereas no hormonal changes occurred in the control groups. It is concluded that patients with normoprolactinemic amenorrhea have elevated basal serum cortisol, the reason probably being hypersecretion of corticotropin-releasing hormone. Secondly that dopaminergic blockade with metoclopramide stimulates ACTH and cortisol secretion in patients presumed to have raised dopaminergic activity.

M3 - Journal article

VL - 118

SP - 544

EP - 550

JO - Acta Endocrinologica (Copenh)

JF - Acta Endocrinologica (Copenh)

IS - 4

ER -

ID: 34131017