Comparison of the effects of SAG-M and whole-blood transfusions on postoperative suppression of delayed hypersensitivity.

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Standard

Comparison of the effects of SAG-M and whole-blood transfusions on postoperative suppression of delayed hypersensitivity. / Nielsen, Hans Jørgen; Hammer, J H; Moesgaard, F; Kehlet, H.

I: Canadian Journal of Surgery, Bind 34, Nr. 2, 1991, s. 146-150.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning

Harvard

Nielsen, HJ, Hammer, JH, Moesgaard, F & Kehlet, H 1991, 'Comparison of the effects of SAG-M and whole-blood transfusions on postoperative suppression of delayed hypersensitivity.', Canadian Journal of Surgery, bind 34, nr. 2, s. 146-150. <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=2025803&query_hl=44>

APA

Nielsen, H. J., Hammer, J. H., Moesgaard, F., & Kehlet, H. (1991). Comparison of the effects of SAG-M and whole-blood transfusions on postoperative suppression of delayed hypersensitivity. Canadian Journal of Surgery, 34(2), 146-150. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=2025803&query_hl=44

Vancouver

Nielsen HJ, Hammer JH, Moesgaard F, Kehlet H. Comparison of the effects of SAG-M and whole-blood transfusions on postoperative suppression of delayed hypersensitivity. Canadian Journal of Surgery. 1991;34(2):146-150.

Author

Nielsen, Hans Jørgen ; Hammer, J H ; Moesgaard, F ; Kehlet, H. / Comparison of the effects of SAG-M and whole-blood transfusions on postoperative suppression of delayed hypersensitivity. I: Canadian Journal of Surgery. 1991 ; Bind 34, Nr. 2. s. 146-150.

Bibtex

@article{d91aa60d2e094759a03f544b261653ef,
title = "Comparison of the effects of SAG-M and whole-blood transfusions on postoperative suppression of delayed hypersensitivity.",
abstract = "The influence of perioperative whole-blood transfusion and transfusion with erythrocyte suspension (SAG-M blood) on postoperative depression of cell-mediated immunity (CMI) was investigated in 67 patients who underwent elective resection for colorectal cancer. Cell-mediated immunity was assessed pre- and postoperatively by skin testing with seven common delayed-type hypersensitivity (DTH) antigens. The postoperative skin-test response decreased more in the patients who received whole blood (15 patients) than in those who received SAG-M blood (16 patients) (60% versus 42%, p less than 0.001) and in those who did not receive a blood transfusion (36 patients) (60% versus 40%, p less than 0.001). The enhanced postoperative immunosuppression in patients who received whole-blood transfusions persisted after matching according to age, sex, height, weight, hemoglobin and serum albumin levels, duration of surgery and diagnosis. Thus, perioperative transfusion with SAG-M blood does not enhance surgically induced immunosuppression as effectively as does transfusion with whole blood.",
author = "Nielsen, {Hans J{\o}rgen} and Hammer, {J H} and F Moesgaard and H Kehlet",
year = "1991",
language = "English",
volume = "34",
pages = "146--150",
journal = "Canadian Journal of Surgery",
issn = "0008-428X",
publisher = "Canadian Medical Association",
number = "2",

}

RIS

TY - JOUR

T1 - Comparison of the effects of SAG-M and whole-blood transfusions on postoperative suppression of delayed hypersensitivity.

AU - Nielsen, Hans Jørgen

AU - Hammer, J H

AU - Moesgaard, F

AU - Kehlet, H

PY - 1991

Y1 - 1991

N2 - The influence of perioperative whole-blood transfusion and transfusion with erythrocyte suspension (SAG-M blood) on postoperative depression of cell-mediated immunity (CMI) was investigated in 67 patients who underwent elective resection for colorectal cancer. Cell-mediated immunity was assessed pre- and postoperatively by skin testing with seven common delayed-type hypersensitivity (DTH) antigens. The postoperative skin-test response decreased more in the patients who received whole blood (15 patients) than in those who received SAG-M blood (16 patients) (60% versus 42%, p less than 0.001) and in those who did not receive a blood transfusion (36 patients) (60% versus 40%, p less than 0.001). The enhanced postoperative immunosuppression in patients who received whole-blood transfusions persisted after matching according to age, sex, height, weight, hemoglobin and serum albumin levels, duration of surgery and diagnosis. Thus, perioperative transfusion with SAG-M blood does not enhance surgically induced immunosuppression as effectively as does transfusion with whole blood.

AB - The influence of perioperative whole-blood transfusion and transfusion with erythrocyte suspension (SAG-M blood) on postoperative depression of cell-mediated immunity (CMI) was investigated in 67 patients who underwent elective resection for colorectal cancer. Cell-mediated immunity was assessed pre- and postoperatively by skin testing with seven common delayed-type hypersensitivity (DTH) antigens. The postoperative skin-test response decreased more in the patients who received whole blood (15 patients) than in those who received SAG-M blood (16 patients) (60% versus 42%, p less than 0.001) and in those who did not receive a blood transfusion (36 patients) (60% versus 40%, p less than 0.001). The enhanced postoperative immunosuppression in patients who received whole-blood transfusions persisted after matching according to age, sex, height, weight, hemoglobin and serum albumin levels, duration of surgery and diagnosis. Thus, perioperative transfusion with SAG-M blood does not enhance surgically induced immunosuppression as effectively as does transfusion with whole blood.

M3 - Journal article

VL - 34

SP - 146

EP - 150

JO - Canadian Journal of Surgery

JF - Canadian Journal of Surgery

SN - 0008-428X

IS - 2

ER -

ID: 34089024