Collagen synthesis in postmenopausal women during therapy with anabolic steroid or female sex hormones
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Collagen synthesis in postmenopausal women during therapy with anabolic steroid or female sex hormones. / Hassager, C; Jensen, L T; Pødenphant, J; Riis, B J; Christiansen, C.
I: Metabolism, Bind 39, Nr. 11, 11.1990, s. 1167-9.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Collagen synthesis in postmenopausal women during therapy with anabolic steroid or female sex hormones
AU - Hassager, C
AU - Jensen, L T
AU - Pødenphant, J
AU - Riis, B J
AU - Christiansen, C
PY - 1990/11
Y1 - 1990/11
N2 - The effect of anabolic steroid therapy and estrogen-progestogen substitution therapy on serum concentration of procollagen type III aminoterminal peptide (PIIINP), a measure of collagen synthesis, in postmenopausal women was studied in two double-blind studies: (1) 39 women allocated to treatment with either 50 mg nandrolone decanoate as an intramuscular depot or placebo injections every third week for 1 year, and (2) 40 women allocated to receive either 2 mg 17 beta-estradiol plus 1 mg norethisterone acetate daily or placebo tablets for 1 year. Serum PIIINP was measured every 3 months during the study. Anabolic steroid therapy resulted in a more than 50% increase (P less than .001) in serum PIIINP at 3 months, which thereafter decayed but remained significantly increased throughout the study period. Serum PIIINP showed the same pattern during estrogen-progestogen therapy, but to a lesser degree. We conclude that anabolic steroids stimulate type III collagen synthesis in postmenopausal women, while estrogen-progestogen therapy may have such an effect, but only to a lesser degree.
AB - The effect of anabolic steroid therapy and estrogen-progestogen substitution therapy on serum concentration of procollagen type III aminoterminal peptide (PIIINP), a measure of collagen synthesis, in postmenopausal women was studied in two double-blind studies: (1) 39 women allocated to treatment with either 50 mg nandrolone decanoate as an intramuscular depot or placebo injections every third week for 1 year, and (2) 40 women allocated to receive either 2 mg 17 beta-estradiol plus 1 mg norethisterone acetate daily or placebo tablets for 1 year. Serum PIIINP was measured every 3 months during the study. Anabolic steroid therapy resulted in a more than 50% increase (P less than .001) in serum PIIINP at 3 months, which thereafter decayed but remained significantly increased throughout the study period. Serum PIIINP showed the same pattern during estrogen-progestogen therapy, but to a lesser degree. We conclude that anabolic steroids stimulate type III collagen synthesis in postmenopausal women, while estrogen-progestogen therapy may have such an effect, but only to a lesser degree.
KW - Aged
KW - Anabolic Agents
KW - Collagen
KW - Drug Combinations
KW - Estradiol
KW - Female
KW - Humans
KW - Menopause
KW - Middle Aged
KW - Nandrolone
KW - Norethindrone
KW - Peptide Fragments
KW - Procollagen
KW - Clinical Trial
KW - Controlled Clinical Trial
KW - Journal Article
M3 - Journal article
C2 - 2233278
VL - 39
SP - 1167
EP - 1169
JO - Metabolism
JF - Metabolism
SN - 0026-0495
IS - 11
ER -
ID: 168533768