Clinical utility of 18F-FDG positron emission tomography/computed tomography scan vs. 99mTc-HMPAO white blood cell single-photon emission computed tomography in extra-cardiac work-up of infective endocarditis

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Standard

Clinical utility of 18F-FDG positron emission tomography/computed tomography scan vs. 99mTc-HMPAO white blood cell single-photon emission computed tomography in extra-cardiac work-up of infective endocarditis. / Lauridsen, Trine K; Iversen, Kasper K; Ihlemann, Nikolaj; Hasbak, Philip; Loft, Annika; Berthelsen, Anne K; Dahl, Anders; Dejanovic, Danijela; Albrecht-Beste, Elisabeth; Mortensen, Jann; Kjær, Andreas; Bundgaard, Henning; Bruun, Niels Eske.

I: International Journal of Cardiovascular Imaging, Bind 33, Nr. 5, 2017, s. 751-760.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Lauridsen, TK, Iversen, KK, Ihlemann, N, Hasbak, P, Loft, A, Berthelsen, AK, Dahl, A, Dejanovic, D, Albrecht-Beste, E, Mortensen, J, Kjær, A, Bundgaard, H & Bruun, NE 2017, 'Clinical utility of 18F-FDG positron emission tomography/computed tomography scan vs. 99mTc-HMPAO white blood cell single-photon emission computed tomography in extra-cardiac work-up of infective endocarditis', International Journal of Cardiovascular Imaging, bind 33, nr. 5, s. 751-760. https://doi.org/10.1007/s10554-016-1047-1

APA

Lauridsen, T. K., Iversen, K. K., Ihlemann, N., Hasbak, P., Loft, A., Berthelsen, A. K., Dahl, A., Dejanovic, D., Albrecht-Beste, E., Mortensen, J., Kjær, A., Bundgaard, H., & Bruun, N. E. (2017). Clinical utility of 18F-FDG positron emission tomography/computed tomography scan vs. 99mTc-HMPAO white blood cell single-photon emission computed tomography in extra-cardiac work-up of infective endocarditis. International Journal of Cardiovascular Imaging, 33(5), 751-760. https://doi.org/10.1007/s10554-016-1047-1

Vancouver

Lauridsen TK, Iversen KK, Ihlemann N, Hasbak P, Loft A, Berthelsen AK o.a. Clinical utility of 18F-FDG positron emission tomography/computed tomography scan vs. 99mTc-HMPAO white blood cell single-photon emission computed tomography in extra-cardiac work-up of infective endocarditis. International Journal of Cardiovascular Imaging. 2017;33(5):751-760. https://doi.org/10.1007/s10554-016-1047-1

Author

Lauridsen, Trine K ; Iversen, Kasper K ; Ihlemann, Nikolaj ; Hasbak, Philip ; Loft, Annika ; Berthelsen, Anne K ; Dahl, Anders ; Dejanovic, Danijela ; Albrecht-Beste, Elisabeth ; Mortensen, Jann ; Kjær, Andreas ; Bundgaard, Henning ; Bruun, Niels Eske. / Clinical utility of 18F-FDG positron emission tomography/computed tomography scan vs. 99mTc-HMPAO white blood cell single-photon emission computed tomography in extra-cardiac work-up of infective endocarditis. I: International Journal of Cardiovascular Imaging. 2017 ; Bind 33, Nr. 5. s. 751-760.

Bibtex

@article{b65d5306b83f44a0bea1cb81583cd0dc,
title = "Clinical utility of 18F-FDG positron emission tomography/computed tomography scan vs. 99mTc-HMPAO white blood cell single-photon emission computed tomography in extra-cardiac work-up of infective endocarditis",
abstract = "The extra-cardiac work-up in infective endocarditis (IE) comprises a search for primary and secondary infective foci. Whether18FDG-PET/CT or WBC-SPECT/CT is superior in detection of clinically relevant extra-cardiac manifestations in IE is unexplored. The objectives of this study were to identify the numbers of positive findings detected by each imaging modality, to evaluate the clinical relevance of these findings and to define the reproducibility for extra-cardiac foci in patients with definite IE. Each modality was evaluated for numbers and location of positive extra-cardiac foci in patients with definite IE. A team of 2 × 2 cardiologists evaluated each finding to determine clinical relevance. Clinical utility was determined by 4 criteria converted into an ordinal scale. Using the manifestation with highest clinical utility rating in each patient, the clinical impact of the two imaging modalities was expressed in a clinical utility score. To evaluate reproducibility for each modality, an imaging core laboratory reviewed all findings. In 55 IE patients, 91 pathological foci were found by FDG-PET/CT and 37 foci were identified by WBC-SPECT/CT (p < 0.001). The clinical utility of FDG-PET/CT was significantly higher than that of WBC-SPECT/CT when comparing clinical utility score (2.06 vs. 1.17; p = 0.01). In assessment of extra-cardiac diagnostics in IE, inter-observer reproducibility was substantial for WBC-SPECT/CT (k 0.69, 95% CI 0.49-0.89) and substantial to excellent for FDG-PET/CT (k 0.79, 95% CI 0.61-0.98). FDG-PET/CT has a significantly higher clinical utility score than WBC SPECT/CT and is potentially superior to WBC-SPECT/CT in detection of extra-cardiac pathology in patients with IE.",
keywords = "Aged, Endocarditis/blood, Female, Fluorodeoxyglucose F18/administration & dosage, Humans, Leukocytes, Male, Middle Aged, Observer Variation, Positron Emission Tomography Computed Tomography, Predictive Value of Tests, Radiopharmaceuticals/administration & dosage, Reproducibility of Results, Single Photon Emission Computed Tomography Computed Tomography, Technetium Tc 99m Exametazime/administration & dosage",
author = "Lauridsen, {Trine K} and Iversen, {Kasper K} and Nikolaj Ihlemann and Philip Hasbak and Annika Loft and Berthelsen, {Anne K} and Anders Dahl and Danijela Dejanovic and Elisabeth Albrecht-Beste and Jann Mortensen and Andreas Kj{\ae}r and Henning Bundgaard and Bruun, {Niels Eske}",
year = "2017",
doi = "10.1007/s10554-016-1047-1",
language = "English",
volume = "33",
pages = "751--760",
journal = "International Journal of Cardiovascular Imaging",
issn = "1569-5794",
publisher = "Springer",
number = "5",

}

RIS

TY - JOUR

T1 - Clinical utility of 18F-FDG positron emission tomography/computed tomography scan vs. 99mTc-HMPAO white blood cell single-photon emission computed tomography in extra-cardiac work-up of infective endocarditis

AU - Lauridsen, Trine K

AU - Iversen, Kasper K

AU - Ihlemann, Nikolaj

AU - Hasbak, Philip

AU - Loft, Annika

AU - Berthelsen, Anne K

AU - Dahl, Anders

AU - Dejanovic, Danijela

AU - Albrecht-Beste, Elisabeth

AU - Mortensen, Jann

AU - Kjær, Andreas

AU - Bundgaard, Henning

AU - Bruun, Niels Eske

PY - 2017

Y1 - 2017

N2 - The extra-cardiac work-up in infective endocarditis (IE) comprises a search for primary and secondary infective foci. Whether18FDG-PET/CT or WBC-SPECT/CT is superior in detection of clinically relevant extra-cardiac manifestations in IE is unexplored. The objectives of this study were to identify the numbers of positive findings detected by each imaging modality, to evaluate the clinical relevance of these findings and to define the reproducibility for extra-cardiac foci in patients with definite IE. Each modality was evaluated for numbers and location of positive extra-cardiac foci in patients with definite IE. A team of 2 × 2 cardiologists evaluated each finding to determine clinical relevance. Clinical utility was determined by 4 criteria converted into an ordinal scale. Using the manifestation with highest clinical utility rating in each patient, the clinical impact of the two imaging modalities was expressed in a clinical utility score. To evaluate reproducibility for each modality, an imaging core laboratory reviewed all findings. In 55 IE patients, 91 pathological foci were found by FDG-PET/CT and 37 foci were identified by WBC-SPECT/CT (p < 0.001). The clinical utility of FDG-PET/CT was significantly higher than that of WBC-SPECT/CT when comparing clinical utility score (2.06 vs. 1.17; p = 0.01). In assessment of extra-cardiac diagnostics in IE, inter-observer reproducibility was substantial for WBC-SPECT/CT (k 0.69, 95% CI 0.49-0.89) and substantial to excellent for FDG-PET/CT (k 0.79, 95% CI 0.61-0.98). FDG-PET/CT has a significantly higher clinical utility score than WBC SPECT/CT and is potentially superior to WBC-SPECT/CT in detection of extra-cardiac pathology in patients with IE.

AB - The extra-cardiac work-up in infective endocarditis (IE) comprises a search for primary and secondary infective foci. Whether18FDG-PET/CT or WBC-SPECT/CT is superior in detection of clinically relevant extra-cardiac manifestations in IE is unexplored. The objectives of this study were to identify the numbers of positive findings detected by each imaging modality, to evaluate the clinical relevance of these findings and to define the reproducibility for extra-cardiac foci in patients with definite IE. Each modality was evaluated for numbers and location of positive extra-cardiac foci in patients with definite IE. A team of 2 × 2 cardiologists evaluated each finding to determine clinical relevance. Clinical utility was determined by 4 criteria converted into an ordinal scale. Using the manifestation with highest clinical utility rating in each patient, the clinical impact of the two imaging modalities was expressed in a clinical utility score. To evaluate reproducibility for each modality, an imaging core laboratory reviewed all findings. In 55 IE patients, 91 pathological foci were found by FDG-PET/CT and 37 foci were identified by WBC-SPECT/CT (p < 0.001). The clinical utility of FDG-PET/CT was significantly higher than that of WBC-SPECT/CT when comparing clinical utility score (2.06 vs. 1.17; p = 0.01). In assessment of extra-cardiac diagnostics in IE, inter-observer reproducibility was substantial for WBC-SPECT/CT (k 0.69, 95% CI 0.49-0.89) and substantial to excellent for FDG-PET/CT (k 0.79, 95% CI 0.61-0.98). FDG-PET/CT has a significantly higher clinical utility score than WBC SPECT/CT and is potentially superior to WBC-SPECT/CT in detection of extra-cardiac pathology in patients with IE.

KW - Aged

KW - Endocarditis/blood

KW - Female

KW - Fluorodeoxyglucose F18/administration & dosage

KW - Humans

KW - Leukocytes

KW - Male

KW - Middle Aged

KW - Observer Variation

KW - Positron Emission Tomography Computed Tomography

KW - Predictive Value of Tests

KW - Radiopharmaceuticals/administration & dosage

KW - Reproducibility of Results

KW - Single Photon Emission Computed Tomography Computed Tomography

KW - Technetium Tc 99m Exametazime/administration & dosage

U2 - 10.1007/s10554-016-1047-1

DO - 10.1007/s10554-016-1047-1

M3 - Journal article

C2 - 28050751

VL - 33

SP - 751

EP - 760

JO - International Journal of Cardiovascular Imaging

JF - International Journal of Cardiovascular Imaging

SN - 1569-5794

IS - 5

ER -

ID: 194814544