Cimetidine treatment of protein-losing gastropathy (Ménétrier's disease). A clinical and pathophysiological study
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Cimetidine treatment of protein-losing gastropathy (Ménétrier's disease). A clinical and pathophysiological study. / Krag, E; Frederiksen, H J; Olsen, N; Henriksen, Jens Henrik Sahl.
I: Scandinavian Journal of Gastroenterology, Bind 13, Nr. 5, 1978, s. 636-9.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Cimetidine treatment of protein-losing gastropathy (Ménétrier's disease). A clinical and pathophysiological study
AU - Krag, E
AU - Frederiksen, H J
AU - Olsen, N
AU - Henriksen, Jens Henrik Sahl
N1 - Keywords: Cimetidine; Guanidines; Humans; Intestinal Absorption; Male; Membrane Potentials; Middle Aged; Protein-Losing Enteropathies; Proteins; Water-Electrolyte Balance
PY - 1978
Y1 - 1978
N2 - In a 47-year-old male with Ménétrier's disease (protein-losing gastropathy) the histamine-H2-receptor antagonist Cimetidine stops the protein loss and improves the clinical condition. Gastric perfusion studies on net and bidirectional ionic fluxes, protein secretion rates, and permeability, with simultaneous recording of the transmural electrical potential difference indicate that Cimetidine decreases a paracellular protein secretion by 'tightening' the tight junctions of the gastric epithelium.
AB - In a 47-year-old male with Ménétrier's disease (protein-losing gastropathy) the histamine-H2-receptor antagonist Cimetidine stops the protein loss and improves the clinical condition. Gastric perfusion studies on net and bidirectional ionic fluxes, protein secretion rates, and permeability, with simultaneous recording of the transmural electrical potential difference indicate that Cimetidine decreases a paracellular protein secretion by 'tightening' the tight junctions of the gastric epithelium.
M3 - Journal article
C2 - 705259
VL - 13
SP - 636
EP - 639
JO - Scandinavian Journal of Gastroenterology
JF - Scandinavian Journal of Gastroenterology
SN - 0036-5521
IS - 5
ER -
ID: 19398750