Child-to-adult body size change and risk of type 2 diabetes and cardiovascular disease
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Child-to-adult body size change and risk of type 2 diabetes and cardiovascular disease. / Carrasquilla, Germán D.; Ängquist, Lars; Sørensen, Thorkild I.A.; Kilpeläinen, Tuomas O.; Loos, Ruth J.F.
I: Diabetologia, Bind 67, 2024, s. 864–873.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Child-to-adult body size change and risk of type 2 diabetes and cardiovascular disease
AU - Carrasquilla, Germán D.
AU - Ängquist, Lars
AU - Sørensen, Thorkild I.A.
AU - Kilpeläinen, Tuomas O.
AU - Loos, Ruth J.F.
N1 - Publisher Copyright: © 2023, The Author(s).
PY - 2024
Y1 - 2024
N2 - Aims/hypothesis: Childhood overweight increases the risk of type 2 diabetes and cardiovascular disease in adulthood. However, the impact of childhood leanness on adult obesity and disease risk has been overlooked. We examined the independent and combined influences of child and adult body size on the risk of type 2 diabetes and cardiovascular disease. Methods: Data from the UK Biobank on 364,695 individuals of European ancestry and free of type 2 diabetes and cardiovascular disease were divided into nine categories based on their self-reported body size at age 10 and measured BMI in adulthood. After a median follow-up of 12.8 years, 33,460 individuals had developed type 2 diabetes and/or cardiovascular disease. We used Cox regression models to assess the associations of body size categories with disease incidence. Results: Individuals with low body size in childhood and high body size in adulthood had the highest risk of type 2 diabetes (HR 4.73; 95% CI 4.50, 4.99), compared to those with average body size in both childhood and adulthood. This was significantly higher than the risk in those with high body size in both childhood and adulthood (HR 4.05; 95% CI 3.84, 4.26). By contrast, cardiovascular disease risk was determined by adult body size, irrespective of childhood body size. Conclusions/interpretation: Low body size in childhood exacerbates the risk of type 2 diabetes associated with adult obesity but not the risk of cardiovascular disease. Thus, promoting healthy weight management from childhood to adulthood, among lean children, is crucial. Graphical Abstract: [Figure not available: see fulltext.].
AB - Aims/hypothesis: Childhood overweight increases the risk of type 2 diabetes and cardiovascular disease in adulthood. However, the impact of childhood leanness on adult obesity and disease risk has been overlooked. We examined the independent and combined influences of child and adult body size on the risk of type 2 diabetes and cardiovascular disease. Methods: Data from the UK Biobank on 364,695 individuals of European ancestry and free of type 2 diabetes and cardiovascular disease were divided into nine categories based on their self-reported body size at age 10 and measured BMI in adulthood. After a median follow-up of 12.8 years, 33,460 individuals had developed type 2 diabetes and/or cardiovascular disease. We used Cox regression models to assess the associations of body size categories with disease incidence. Results: Individuals with low body size in childhood and high body size in adulthood had the highest risk of type 2 diabetes (HR 4.73; 95% CI 4.50, 4.99), compared to those with average body size in both childhood and adulthood. This was significantly higher than the risk in those with high body size in both childhood and adulthood (HR 4.05; 95% CI 3.84, 4.26). By contrast, cardiovascular disease risk was determined by adult body size, irrespective of childhood body size. Conclusions/interpretation: Low body size in childhood exacerbates the risk of type 2 diabetes associated with adult obesity but not the risk of cardiovascular disease. Thus, promoting healthy weight management from childhood to adulthood, among lean children, is crucial. Graphical Abstract: [Figure not available: see fulltext.].
KW - Cardiovascular diseases
KW - Follow-up studies
KW - Obesity
KW - Paediatric obesity
KW - Preventive medicine
KW - Public health
KW - Type 2 diabetes
KW - Weight gain
U2 - 10.1007/s00125-023-06058-4
DO - 10.1007/s00125-023-06058-4
M3 - Journal article
C2 - 38085289
AN - SCOPUS:85179357236
VL - 67
SP - 864
EP - 873
JO - Diabetologia
JF - Diabetologia
SN - 0012-186X
ER -
ID: 378127441