Chemokine Oligomers and the Impact of Fondaparinux Binding

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Standard

Chemokine Oligomers and the Impact of Fondaparinux Binding. / Szekeres, Gergo Peter; Dyer, Douglas P.; Miller, Rebecca L.; Pagel, Kevin.

I: Journal of the American Society for Mass Spectrometry, 2024.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Szekeres, GP, Dyer, DP, Miller, RL & Pagel, K 2024, 'Chemokine Oligomers and the Impact of Fondaparinux Binding', Journal of the American Society for Mass Spectrometry. https://doi.org/10.1021/jasms.4c00142

APA

Szekeres, G. P., Dyer, D. P., Miller, R. L., & Pagel, K. (2024). Chemokine Oligomers and the Impact of Fondaparinux Binding. Journal of the American Society for Mass Spectrometry. https://doi.org/10.1021/jasms.4c00142

Vancouver

Szekeres GP, Dyer DP, Miller RL, Pagel K. Chemokine Oligomers and the Impact of Fondaparinux Binding. Journal of the American Society for Mass Spectrometry. 2024. https://doi.org/10.1021/jasms.4c00142

Author

Szekeres, Gergo Peter ; Dyer, Douglas P. ; Miller, Rebecca L. ; Pagel, Kevin. / Chemokine Oligomers and the Impact of Fondaparinux Binding. I: Journal of the American Society for Mass Spectrometry. 2024.

Bibtex

@article{d52e175e9a7545f4868c148010b0438f,

title = "Chemokine Oligomers and the Impact of Fondaparinux Binding",

abstract = "Heparin, a widely used clinical anticoagulant, is generally well-tolerated; however, approximately 1% of patients develop heparin-induced thrombocytopenia (HIT), a serious side effect. While efforts to understand the role of chemokines in HIT development are ongoing, certain aspects remain less studied, such as the stabilization of chemokine oligomers by heparin. Here, we conducted a combined ion mobility-native mass spectrometry study to investigate the stability of chemokine oligomers and their complexes with fondaparinux, a synthetic heparin analog. Collision-induced dissociation and unfolding experiments provided clarity on the specificity and relevance of chemokine oligomers and their fondaparinux complexes with varying stoichiometries, as well as the stabilizing effects of fondaparinux binding.",

author = "Szekeres, {Gergo Peter} and Dyer, {Douglas P.} and Miller, {Rebecca L.} and Kevin Pagel",

note = "Publisher Copyright: {\textcopyright} 2024 The Authors. Published by American Chemical Society.",

year = "2024",

doi = "10.1021/jasms.4c00142",

language = "English",

journal = "Journal of The American Society for Mass Spectrometry",

issn = "1044-0305",

publisher = "Springer Nature",

}

RIS

TY - JOUR

T1 - Chemokine Oligomers and the Impact of Fondaparinux Binding

AU - Szekeres, Gergo Peter

AU - Dyer, Douglas P.

AU - Miller, Rebecca L.

AU - Pagel, Kevin

PY - 2024

Y1 - 2024

N2 - Heparin, a widely used clinical anticoagulant, is generally well-tolerated; however, approximately 1% of patients develop heparin-induced thrombocytopenia (HIT), a serious side effect. While efforts to understand the role of chemokines in HIT development are ongoing, certain aspects remain less studied, such as the stabilization of chemokine oligomers by heparin. Here, we conducted a combined ion mobility-native mass spectrometry study to investigate the stability of chemokine oligomers and their complexes with fondaparinux, a synthetic heparin analog. Collision-induced dissociation and unfolding experiments provided clarity on the specificity and relevance of chemokine oligomers and their fondaparinux complexes with varying stoichiometries, as well as the stabilizing effects of fondaparinux binding.

AB - Heparin, a widely used clinical anticoagulant, is generally well-tolerated; however, approximately 1% of patients develop heparin-induced thrombocytopenia (HIT), a serious side effect. While efforts to understand the role of chemokines in HIT development are ongoing, certain aspects remain less studied, such as the stabilization of chemokine oligomers by heparin. Here, we conducted a combined ion mobility-native mass spectrometry study to investigate the stability of chemokine oligomers and their complexes with fondaparinux, a synthetic heparin analog. Collision-induced dissociation and unfolding experiments provided clarity on the specificity and relevance of chemokine oligomers and their fondaparinux complexes with varying stoichiometries, as well as the stabilizing effects of fondaparinux binding.

U2 - 10.1021/jasms.4c00142

DO - 10.1021/jasms.4c00142

M3 - Journal article

C2 - 38836362

AN - SCOPUS:85195286733

JO - Journal of The American Society for Mass Spectrometry

JF - Journal of The American Society for Mass Spectrometry

SN - 1044-0305

ER -

ID: 395088401

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