Characterization of oral and intravenous glucose handling in truncally vagotomised subjects with pyloroplasty
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Characterization of oral and intravenous glucose handling in truncally vagotomised subjects with pyloroplasty. / Plamboeck, Astrid; Veedfald, Simon; Deacon, Carolyn; Hartmann, Bolette; Wettergren, Andre; Svendsen, Lars Bo; Meisner, Søren; Hovendal, Claus; Knop, Filip Krag; Vilsbøll, Tina; Holst, Jens Juul.
I: European Journal of Endocrinology, Bind 169, 23.05.2013, s. 187-201.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › fagfællebedømt
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TY - JOUR
T1 - Characterization of oral and intravenous glucose handling in truncally vagotomised subjects with pyloroplasty
AU - Plamboeck, Astrid
AU - Veedfald, Simon
AU - Deacon, Carolyn
AU - Hartmann, Bolette
AU - Wettergren, Andre
AU - Svendsen, Lars Bo
AU - Meisner, Søren
AU - Hovendal, Claus
AU - Knop, Filip Krag
AU - Vilsbøll, Tina
AU - Holst, Jens Juul
PY - 2013/5/23
Y1 - 2013/5/23
N2 - OBJECTIVE: Glucagon-like peptide-1 (GLP-1) is rapidly inactivated by dipeptidyl peptidase 4, but may interact with vagal neurons at its site of secretion. We investigated the role of vagal innervation for handling of oral and iv glucose. Design and methods: Truncally vagotomised subjects (n=16) and matched controls (n=10) underwent 50g oral glucose tolerance test (OGTT)±vildagliptin, a DPP-4 inhibitor (DPP-4i) and isoglycaemic iv glucose infusion (IIGI) copying the OGTT without DPP-4i. Results: Isoglycaemia was obtained with 25±2 g glucose in vagotomised subjects and 18±2 g in controls (P
AB - OBJECTIVE: Glucagon-like peptide-1 (GLP-1) is rapidly inactivated by dipeptidyl peptidase 4, but may interact with vagal neurons at its site of secretion. We investigated the role of vagal innervation for handling of oral and iv glucose. Design and methods: Truncally vagotomised subjects (n=16) and matched controls (n=10) underwent 50g oral glucose tolerance test (OGTT)±vildagliptin, a DPP-4 inhibitor (DPP-4i) and isoglycaemic iv glucose infusion (IIGI) copying the OGTT without DPP-4i. Results: Isoglycaemia was obtained with 25±2 g glucose in vagotomised subjects and 18±2 g in controls (P
U2 - 10.1530/EJE-13-0264
DO - 10.1530/EJE-13-0264
M3 - Journal article
C2 - 23704713
VL - 169
SP - 187
EP - 201
JO - European Journal of Endocrinology
JF - European Journal of Endocrinology
SN - 0804-4643
ER -
ID: 45842367