Changes in Inflammatory Cytokines in Responders and Non-Responders to TNFα Inhibitor and IL-17A Inhibitor: A Study Examining Psoriatic Arthritis Patients
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his study aimed to examine the changes in biomarker levels in responders and non-responders to tumor necrosis factor alpha inhibitor (TNFi) and interleukin-17A inhibitor (IL-17Ai) in psoriatic arthritis (PsA) patients over a 4-month period after treatment initiation. A total of 68 PsA patients initiating either TNFi, IL-17Ai, or methotrexate treatment were included. Blood plasma and clinical outcome measures were collected adjacent to treatment initiation and after four months. A commercially available multiplex immunoassay was included to evaluate 54 biomarkers. Mean changes were used to evaluate change over time. A statistically significant decrease in pro-inflammatory cytokines IL-6 (log-transformed mean change −0.97, 95%CI −4.30; 2.37, [p = 0.032]) and an increase in anti-inflammatory IL-10 (0.38, 95%CI 1.74; 2.50 [p = 0.010]) were seen in TNFi responders. Meanwhile, a statistically significant increase in the target cytokine IL-17A was seen in both IL-17Ai responders (2.49, 95%CI −1.84; 6.85 [p = 0.031]) and non-responders (2.48, 95%CI −1.46; 6.41 [p = 0.001]). This study demonstrated differing changes in cytokine levels when comparing treatment responders and non-responders, highlighting the need to improve the understanding of the different immune response mechanisms explaining different responses to medical treatment in PsA patients.
Keywords: psoriatic arthritis; cytokine; bDMARDs; TNFα; IL-17A
Keywords: psoriatic arthritis; cytokine; bDMARDs; TNFα; IL-17A
Originalsprog | Engelsk |
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Artikelnummer | 3002 |
Tidsskrift | International Journal of Molecular Sciences |
Vol/bind | 25 |
Udgave nummer | 5 |
Antal sider | 15 |
ISSN | 1661-6596 |
DOI | |
Status | Udgivet - 2024 |
Bibliografisk note
Funding Information:
This work was supported by an Investigator-Initiated Research Grant from Lilly (I1F-NS-O004), The Danish Rheumatism Association (R188-A6597)), Elisabeth and Karl Ejnar Nis-Hanssens Mindelegat and Minister Erna Hamiltons Legat for Videnskab og Kunst. The study was further supported by an unrestricted core grant to the Parker Institute from the Oak Foundation (OCAY-18-774-OFIL).
Publisher Copyright:
© 2024 by the authors.
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