Cerebral blood flow in patients with congestive heart failure treated with captopril
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Cerebral blood flow in patients with congestive heart failure treated with captopril. / Paulson, O B; Jarden, J O; Godtfredsen, J; Vorstrup, S.
I: The American Journal of Medicine, Bind 76, Nr. 5B, 31.05.1984, s. 91-5.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Cerebral blood flow in patients with congestive heart failure treated with captopril
AU - Paulson, O B
AU - Jarden, J O
AU - Godtfredsen, J
AU - Vorstrup, S
PY - 1984/5/31
Y1 - 1984/5/31
N2 - The effect of captopril on cerebral blood flow was studied in five patients with severe congestive heart failure and in five control subjects. Cerebral blood flow was measured by inhalation of 133xenon and registration of its uptake and washout from the brain by single photon emission computer tomography. In addition, cerebral (internal jugular) venous oxygen tension was determined in the controls. The measurements were made before and 15, 60, and 180 minutes after a single oral dose of captopril (6.25 mg in patients with congestive heart failure and 25 mg in controls). Despite a marked decrease in blood pressure, cerebral blood flow increased slightly in the patients with severe congestive heart failure. When a correction was applied to take account of a change in arterial carbon dioxide tension, however, cerebral blood flow was unchanged after captopril administration even in patients with the greatest decrease in blood pressure, in whom a decrease in cerebral blood flow might have been expected. In the controls, blood pressure was little affected by captopril, whereas a slight, but not statistically significant, decrease in cerebral blood flow was observed. The cerebral venous oxygen tension decreased concomitantly.
AB - The effect of captopril on cerebral blood flow was studied in five patients with severe congestive heart failure and in five control subjects. Cerebral blood flow was measured by inhalation of 133xenon and registration of its uptake and washout from the brain by single photon emission computer tomography. In addition, cerebral (internal jugular) venous oxygen tension was determined in the controls. The measurements were made before and 15, 60, and 180 minutes after a single oral dose of captopril (6.25 mg in patients with congestive heart failure and 25 mg in controls). Despite a marked decrease in blood pressure, cerebral blood flow increased slightly in the patients with severe congestive heart failure. When a correction was applied to take account of a change in arterial carbon dioxide tension, however, cerebral blood flow was unchanged after captopril administration even in patients with the greatest decrease in blood pressure, in whom a decrease in cerebral blood flow might have been expected. In the controls, blood pressure was little affected by captopril, whereas a slight, but not statistically significant, decrease in cerebral blood flow was observed. The cerebral venous oxygen tension decreased concomitantly.
KW - Adult
KW - Angiotensin-Converting Enzyme Inhibitors
KW - Blood Pressure/drug effects
KW - Brain/diagnostic imaging
KW - Captopril/therapeutic use
KW - Cerebrovascular Circulation/drug effects
KW - Heart Failure/diagnostic imaging
KW - Humans
KW - Middle Aged
KW - Proline/analogs & derivatives
KW - Pulmonary Gas Exchange/drug effects
KW - Tomography, Emission-Computed
KW - Xenon Radioisotopes
U2 - 10.1016/0002-9343(84)90892-1
DO - 10.1016/0002-9343(84)90892-1
M3 - Journal article
C2 - 6328991
VL - 76
SP - 91
EP - 95
JO - American Journal of Medicine
JF - American Journal of Medicine
SN - 0002-9343
IS - 5B
ER -
ID: 279582828