Can the DEX/CRH test or markers of oxidative stress distinguish work-related stress from major depressive disorder and normal controls?

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Standard

Can the DEX/CRH test or markers of oxidative stress distinguish work-related stress from major depressive disorder and normal controls? / Rotvig, Ditte H.; Jorgensen, Anders; Jensen, Johan Høy; Hansen, Allan Rene; Eller, Nanna Hurwitz; Jonsson, Steffen H.; Knorr, Ulla; Klose, Marianne C.; Feldt-Rasmussen, Ulla; Menke, Andreas; Poulsen, Henrik Enghusen; Bauer, Jeanett; Jørgensen, Martin Balslev.

I: Stress, Bind 27, Nr. 1, 2353781, 2024.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Rotvig, DH, Jorgensen, A, Jensen, JH, Hansen, AR, Eller, NH, Jonsson, SH, Knorr, U, Klose, MC, Feldt-Rasmussen, U, Menke, A, Poulsen, HE, Bauer, J & Jørgensen, MB 2024, 'Can the DEX/CRH test or markers of oxidative stress distinguish work-related stress from major depressive disorder and normal controls?', Stress, bind 27, nr. 1, 2353781. https://doi.org/10.1080/10253890.2024.2353781

APA

Rotvig, D. H., Jorgensen, A., Jensen, J. H., Hansen, A. R., Eller, N. H., Jonsson, S. H., Knorr, U., Klose, M. C., Feldt-Rasmussen, U., Menke, A., Poulsen, H. E., Bauer, J., & Jørgensen, M. B. (2024). Can the DEX/CRH test or markers of oxidative stress distinguish work-related stress from major depressive disorder and normal controls? Stress, 27(1), [2353781]. https://doi.org/10.1080/10253890.2024.2353781

Vancouver

Rotvig DH, Jorgensen A, Jensen JH, Hansen AR, Eller NH, Jonsson SH o.a. Can the DEX/CRH test or markers of oxidative stress distinguish work-related stress from major depressive disorder and normal controls? Stress. 2024;27(1). 2353781. https://doi.org/10.1080/10253890.2024.2353781

Author

Rotvig, Ditte H. ; Jorgensen, Anders ; Jensen, Johan Høy ; Hansen, Allan Rene ; Eller, Nanna Hurwitz ; Jonsson, Steffen H. ; Knorr, Ulla ; Klose, Marianne C. ; Feldt-Rasmussen, Ulla ; Menke, Andreas ; Poulsen, Henrik Enghusen ; Bauer, Jeanett ; Jørgensen, Martin Balslev. / Can the DEX/CRH test or markers of oxidative stress distinguish work-related stress from major depressive disorder and normal controls?. I: Stress. 2024 ; Bind 27, Nr. 1.

Bibtex

@article{7b448e90b8f945d38f9b0c4274a51703,

title = "Can the DEX/CRH test or markers of oxidative stress distinguish work-related stress from major depressive disorder and normal controls?",

abstract = "Hypothalamic-pituitary-adrenal (HPA)-axis hyperactivity measured by the combined dexamethasone-CRH test (DEX-CRH test) has been found in patients with major depressive disorder (MDD), whereas hypoactivity has been found in patients with work-related stress. We aimed to investigate the DEX-CRH test as a biomarker to distinguish between MDD and work-related stress (exhaustion disorder - ED). We hypothesized that there would be lower cortisol and ACTH response in participants with ED compared to MDD and healthy controls (HC). Also, we explored if the cortisol response of those patients interacted with robust markers of oxidative stress. Thirty inpatients with MDD and 23 outpatients with ED were recruited. Plasma cortisol and ACTH were sampled during a DEX-CRH test. The main outcome measure, area under the curve (AUC) for cortisol and ACTH, was compa-red between MDD vs. ED participants and a historical HC group. Secondary markers of oxidative stress urinary 8-oxodG and 8-oxoGuo; quality of sleep and psychometrics were obtained. Cortisol concentrations were higher in MDD and ED participants compared to HC, and no differences in AUC cortisol and ACTH were found between ED vs. MDD. Compared to ED, MDD participants had higher stress symptom severity and a lower sense of well-being. No differences in oxidative stress markers or quality of sleep between the groups were found. The result indicates that the patients with ED, like patients with MDD, are non-suppressors in DEX-CRH test and not hypocortisolemic as suggested.",

keywords = "cortisol, dexamethasone-CRH suppression test, HPA axis, major depression, oxidative stress, Work stress",

author = "Rotvig, {Ditte H.} and Anders Jorgensen and Jensen, {Johan H{\o}y} and Hansen, {Allan Rene} and Eller, {Nanna Hurwitz} and Jonsson, {Steffen H.} and Ulla Knorr and Klose, {Marianne C.} and Ulla Feldt-Rasmussen and Andreas Menke and Poulsen, {Henrik Enghusen} and Jeanett Bauer and J{\o}rgensen, {Martin Balslev}",

note = "Publisher Copyright: {\textcopyright} 2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.",

year = "2024",

doi = "10.1080/10253890.2024.2353781",

language = "English",

volume = "27",

journal = "Stress: The International Journal on the Biology of Stress ",

issn = "1025-3890",

publisher = "Taylor & Francis",

number = "1",