calderón encodes an organic cation transporter of the major facilitator superfamily required for cell growth and proliferation of Drosophila tissues

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Standard

calderón encodes an organic cation transporter of the major facilitator superfamily required for cell growth and proliferation of Drosophila tissues. / Herranz, Héctor; Morata, Ginés; Milán, Marco.

I: Development (Cambridge, England), Bind 133, Nr. 14, 07.2006, s. 2617-25.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Herranz, H, Morata, G & Milán, M 2006, 'calderón encodes an organic cation transporter of the major facilitator superfamily required for cell growth and proliferation of Drosophila tissues', Development (Cambridge, England), bind 133, nr. 14, s. 2617-25. https://doi.org/10.1242/dev.02436

APA

Herranz, H., Morata, G., & Milán, M. (2006). calderón encodes an organic cation transporter of the major facilitator superfamily required for cell growth and proliferation of Drosophila tissues. Development (Cambridge, England), 133(14), 2617-25. https://doi.org/10.1242/dev.02436

Vancouver

Herranz H, Morata G, Milán M. calderón encodes an organic cation transporter of the major facilitator superfamily required for cell growth and proliferation of Drosophila tissues. Development (Cambridge, England). 2006 jul.;133(14):2617-25. https://doi.org/10.1242/dev.02436

Author

Herranz, Héctor ; Morata, Ginés ; Milán, Marco. / calderón encodes an organic cation transporter of the major facilitator superfamily required for cell growth and proliferation of Drosophila tissues. I: Development (Cambridge, England). 2006 ; Bind 133, Nr. 14. s. 2617-25.

Bibtex

@article{f3eb018ca4734387b42ad1ee6aaf4d0c,
title = "calder{\'o}n encodes an organic cation transporter of the major facilitator superfamily required for cell growth and proliferation of Drosophila tissues",
abstract = "The adaptation of growth in response to dietary changes is essential for the normal development of all organisms. The insulin receptor (InR) signalling pathway controls growth and metabolism in response to nutrient availability. The elements of this pathway have been described, although little is known about the downstream elements regulated by this cascade. We identified calder{\'o}n, a gene that encodes a protein with highest homology with organic cation transporters of the major facilitator superfamily, as a new transcriptional target of the InR pathway. These transporters are believed to function mainly in the uptake of sugars, as well as other organic metabolites. Genetic experiments demonstrate that calder{\'o}n is required cell autonomously and downstream of the InR pathway for normal growth and proliferation of larval tissues. Our results indicate that growth of imaginal cells may be modulated by two distinct, but coordinated, nutrient-sensing mechanisms: one cell-autonomous and the other humoral.",
keywords = "Amino Acid Sequence, Animals, Cell Proliferation, Drosophila Proteins, Drosophila melanogaster, Embryonic Structures, Humans, Insulin, Molecular Sequence Data, Organic Cation Transport Proteins, Phenotype, Receptor, Insulin, Sequence Alignment, Sequence Homology, Nucleic Acid, Signal Transduction",
author = "H{\'e}ctor Herranz and Gin{\'e}s Morata and Marco Mil{\'a}n",
year = "2006",
month = jul,
doi = "10.1242/dev.02436",
language = "English",
volume = "133",
pages = "2617--25",
journal = "Development",
issn = "0950-1991",
publisher = "The Company of Biologists",
number = "14",

}

RIS

TY - JOUR

T1 - calderón encodes an organic cation transporter of the major facilitator superfamily required for cell growth and proliferation of Drosophila tissues

AU - Herranz, Héctor

AU - Morata, Ginés

AU - Milán, Marco

PY - 2006/7

Y1 - 2006/7

N2 - The adaptation of growth in response to dietary changes is essential for the normal development of all organisms. The insulin receptor (InR) signalling pathway controls growth and metabolism in response to nutrient availability. The elements of this pathway have been described, although little is known about the downstream elements regulated by this cascade. We identified calderón, a gene that encodes a protein with highest homology with organic cation transporters of the major facilitator superfamily, as a new transcriptional target of the InR pathway. These transporters are believed to function mainly in the uptake of sugars, as well as other organic metabolites. Genetic experiments demonstrate that calderón is required cell autonomously and downstream of the InR pathway for normal growth and proliferation of larval tissues. Our results indicate that growth of imaginal cells may be modulated by two distinct, but coordinated, nutrient-sensing mechanisms: one cell-autonomous and the other humoral.

AB - The adaptation of growth in response to dietary changes is essential for the normal development of all organisms. The insulin receptor (InR) signalling pathway controls growth and metabolism in response to nutrient availability. The elements of this pathway have been described, although little is known about the downstream elements regulated by this cascade. We identified calderón, a gene that encodes a protein with highest homology with organic cation transporters of the major facilitator superfamily, as a new transcriptional target of the InR pathway. These transporters are believed to function mainly in the uptake of sugars, as well as other organic metabolites. Genetic experiments demonstrate that calderón is required cell autonomously and downstream of the InR pathway for normal growth and proliferation of larval tissues. Our results indicate that growth of imaginal cells may be modulated by two distinct, but coordinated, nutrient-sensing mechanisms: one cell-autonomous and the other humoral.

KW - Amino Acid Sequence

KW - Animals

KW - Cell Proliferation

KW - Drosophila Proteins

KW - Drosophila melanogaster

KW - Embryonic Structures

KW - Humans

KW - Insulin

KW - Molecular Sequence Data

KW - Organic Cation Transport Proteins

KW - Phenotype

KW - Receptor, Insulin

KW - Sequence Alignment

KW - Sequence Homology, Nucleic Acid

KW - Signal Transduction

U2 - 10.1242/dev.02436

DO - 10.1242/dev.02436

M3 - Journal article

C2 - 16774996

VL - 133

SP - 2617

EP - 2625

JO - Development

JF - Development

SN - 0950-1991

IS - 14

ER -

ID: 119179855