Calcium and vitamin D homoeostasis in male fertility
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Calcium and vitamin D have well-established roles in maintaining calcium balance and bone health. Decades of research in human subjects and animals have revealed that calcium and vitamin D also have effects on many other organs including male reproductive organs. The presence of calcium-sensing receptor, vitamin D receptor, vitamin D activating and inactivating enzymes and calcium channels in the testes, male reproductive tract and human spermatozoa suggests that vitamin D and calcium may modify male reproductive function. Functional animal models have shown that vitamin D deficiency in male rodents leads to a decrease in successful mating and fewer pregnancies, often caused by impaired sperm motility and poor sperm morphology. Human studies have to a lesser extent validated these findings; however, newer studies suggest a positive effect of vitamin D supplementation on semen quality in cases with vitamin D deficiency, which highlights the need for initiatives to prevent vitamin D deficiency. Calcium channels in male reproductive organs and spermatozoa contribute to the regulation of sperm motility and capacitation, both essential for successful fertilisation, which supports a need to avoid calcium deficiency. Studies have demonstrated that vitamin D, as a regulator of calcium homoeostasis, influences calcium influx in the testis and spermatozoa. Emerging evidence suggests a potential link between vitamin D deficiency and male infertility, although further investigation is needed to establish a definitive causal relationship. Understanding the interplay between vitamin D, calcium and male reproductive health may open new avenues for improving fertility outcomes in men.
Originalsprog | Engelsk |
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Tidsskrift | Proceedings of the Nutrition Society |
Vol/bind | 83 |
Udgave nummer | 2 |
Sider (fra-til) | 95-108 |
Antal sider | 14 |
ISSN | 0029-6651 |
DOI | |
Status | Udgivet - 2024 |
Begivenhed | The Nutrition Society Irish Section Conference 2023 - Technological University of the Shannon, Athlone, Irland Varighed: 14 jun. 2023 → 16 jun. 2023 |
Konference
Konference | The Nutrition Society Irish Section Conference 2023 |
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Lokation | Technological University of the Shannon |
Land | Irland |
By | Athlone |
Periode | 14/06/2023 → 16/06/2023 |
ID: 387110088