Broadly neutralizing antibodies targeted to mucin-type carbohydrate epitopes of human immunodeficiency virus.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning
The cancer-related mucin-type carbohydrate neoantigen Tn was found on gp160 and gp120 of human immunodeficiency virus (HIV). Immunoglobulin G (IgG) and IgM monoclonal antibodies (MAbs) against Tn neutralized infection with cell-free virus and blocked fusion between HIV-infected and uninfected cells. This inhibition was found in infection of both lymphocytic cells and monocytoid cells. Viruses tested included six HIV-1 and five HIV-2 isolates propagated in different cells, as well as infectious plasma from AIDS patients. The antiviral effect of anti-Tn MAbs occurred by specific binding of the MAb to the virus; this binding was inhibitable by pure Tn antigen, and indications were found that this inhibition occurred at a pre-entry step. Boosting the naturally occurring low-titer anti-Tn activity may be of prophylactic value, as suggested by the in vitro neutralization found in this study.
Bidragets oversatte titel | Broadly neutralizing antibodies targeted to mucin-type carbohydrate epitopes of human immunodeficiency virus. |
---|---|
Originalsprog | Engelsk |
Tidsskrift | Journal of Virology |
Vol/bind | 65 |
Udgave nummer | 12 |
Sider (fra-til) | 6461-6467 |
Antal sider | 7 |
ISSN | 0022-538X |
Status | Udgivet - 1991 |
ID: 34125763