Broadly neutralizing antibodies targeted to mucin-type carbohydrate epitopes of human immunodeficiency virus.

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Standard

Broadly neutralizing antibodies targeted to mucin-type carbohydrate epitopes of human immunodeficiency virus. / Hansen, J E; Nielsen, C; Arendrup, M; Olofsson, S; Mathiesen, Lars Reinhardt; Nielsen, Jens Ole; Clausen, H.

I: Journal of Virology, Bind 65, Nr. 12, 1991, s. 6461-6467.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning

Harvard

Hansen, JE, Nielsen, C, Arendrup, M, Olofsson, S, Mathiesen, LR, Nielsen, JO & Clausen, H 1991, 'Broadly neutralizing antibodies targeted to mucin-type carbohydrate epitopes of human immunodeficiency virus.', Journal of Virology, bind 65, nr. 12, s. 6461-6467. <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=1719230&query_hl=96>

APA

Hansen, J. E., Nielsen, C., Arendrup, M., Olofsson, S., Mathiesen, L. R., Nielsen, J. O., & Clausen, H. (1991). Broadly neutralizing antibodies targeted to mucin-type carbohydrate epitopes of human immunodeficiency virus. Journal of Virology, 65(12), 6461-6467. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=1719230&query_hl=96

Vancouver

Hansen JE, Nielsen C, Arendrup M, Olofsson S, Mathiesen LR, Nielsen JO o.a. Broadly neutralizing antibodies targeted to mucin-type carbohydrate epitopes of human immunodeficiency virus. Journal of Virology. 1991;65(12):6461-6467.

Author

Hansen, J E ; Nielsen, C ; Arendrup, M ; Olofsson, S ; Mathiesen, Lars Reinhardt ; Nielsen, Jens Ole ; Clausen, H. / Broadly neutralizing antibodies targeted to mucin-type carbohydrate epitopes of human immunodeficiency virus. I: Journal of Virology. 1991 ; Bind 65, Nr. 12. s. 6461-6467.

Bibtex

@article{8b7dd4f1d22c45d39359f7d65dcbda32,
title = "Broadly neutralizing antibodies targeted to mucin-type carbohydrate epitopes of human immunodeficiency virus.",
abstract = "The cancer-related mucin-type carbohydrate neoantigen Tn was found on gp160 and gp120 of human immunodeficiency virus (HIV). Immunoglobulin G (IgG) and IgM monoclonal antibodies (MAbs) against Tn neutralized infection with cell-free virus and blocked fusion between HIV-infected and uninfected cells. This inhibition was found in infection of both lymphocytic cells and monocytoid cells. Viruses tested included six HIV-1 and five HIV-2 isolates propagated in different cells, as well as infectious plasma from AIDS patients. The antiviral effect of anti-Tn MAbs occurred by specific binding of the MAb to the virus; this binding was inhibitable by pure Tn antigen, and indications were found that this inhibition occurred at a pre-entry step. Boosting the naturally occurring low-titer anti-Tn activity may be of prophylactic value, as suggested by the in vitro neutralization found in this study.",
author = "Hansen, {J E} and C Nielsen and M Arendrup and S Olofsson and Mathiesen, {Lars Reinhardt} and Nielsen, {Jens Ole} and H Clausen",
year = "1991",
language = "English",
volume = "65",
pages = "6461--6467",
journal = "Journal of Virology",
issn = "0022-538X",
publisher = "American Society for Microbiology",
number = "12",

}

RIS

TY - JOUR

T1 - Broadly neutralizing antibodies targeted to mucin-type carbohydrate epitopes of human immunodeficiency virus.

AU - Hansen, J E

AU - Nielsen, C

AU - Arendrup, M

AU - Olofsson, S

AU - Mathiesen, Lars Reinhardt

AU - Nielsen, Jens Ole

AU - Clausen, H

PY - 1991

Y1 - 1991

N2 - The cancer-related mucin-type carbohydrate neoantigen Tn was found on gp160 and gp120 of human immunodeficiency virus (HIV). Immunoglobulin G (IgG) and IgM monoclonal antibodies (MAbs) against Tn neutralized infection with cell-free virus and blocked fusion between HIV-infected and uninfected cells. This inhibition was found in infection of both lymphocytic cells and monocytoid cells. Viruses tested included six HIV-1 and five HIV-2 isolates propagated in different cells, as well as infectious plasma from AIDS patients. The antiviral effect of anti-Tn MAbs occurred by specific binding of the MAb to the virus; this binding was inhibitable by pure Tn antigen, and indications were found that this inhibition occurred at a pre-entry step. Boosting the naturally occurring low-titer anti-Tn activity may be of prophylactic value, as suggested by the in vitro neutralization found in this study.

AB - The cancer-related mucin-type carbohydrate neoantigen Tn was found on gp160 and gp120 of human immunodeficiency virus (HIV). Immunoglobulin G (IgG) and IgM monoclonal antibodies (MAbs) against Tn neutralized infection with cell-free virus and blocked fusion between HIV-infected and uninfected cells. This inhibition was found in infection of both lymphocytic cells and monocytoid cells. Viruses tested included six HIV-1 and five HIV-2 isolates propagated in different cells, as well as infectious plasma from AIDS patients. The antiviral effect of anti-Tn MAbs occurred by specific binding of the MAb to the virus; this binding was inhibitable by pure Tn antigen, and indications were found that this inhibition occurred at a pre-entry step. Boosting the naturally occurring low-titer anti-Tn activity may be of prophylactic value, as suggested by the in vitro neutralization found in this study.

M3 - Journal article

VL - 65

SP - 6461

EP - 6467

JO - Journal of Virology

JF - Journal of Virology

SN - 0022-538X

IS - 12

ER -

ID: 34125763