Brain marker protein changes after short- and long-term ethanol intoxication and withdrawal in the rat.

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Standard

Brain marker protein changes after short- and long-term ethanol intoxication and withdrawal in the rat. / Clemmesen, L; Jørgensen, Ole Steen; Hemmingsen, R; Barry, D I; Bolwig, T G.

I: Journal of Psychiatric Research, Bind 21, Nr. 2, 1987, s. 171-83.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Clemmesen, L, Jørgensen, OS, Hemmingsen, R, Barry, DI & Bolwig, TG 1987, 'Brain marker protein changes after short- and long-term ethanol intoxication and withdrawal in the rat.', Journal of Psychiatric Research, bind 21, nr. 2, s. 171-83.

APA

Clemmesen, L., Jørgensen, O. S., Hemmingsen, R., Barry, D. I., & Bolwig, T. G. (1987). Brain marker protein changes after short- and long-term ethanol intoxication and withdrawal in the rat. Journal of Psychiatric Research, 21(2), 171-83.

Vancouver

Clemmesen L, Jørgensen OS, Hemmingsen R, Barry DI, Bolwig TG. Brain marker protein changes after short- and long-term ethanol intoxication and withdrawal in the rat. Journal of Psychiatric Research. 1987;21(2):171-83.

Author

Clemmesen, L ; Jørgensen, Ole Steen ; Hemmingsen, R ; Barry, D I ; Bolwig, T G. / Brain marker protein changes after short- and long-term ethanol intoxication and withdrawal in the rat. I: Journal of Psychiatric Research. 1987 ; Bind 21, Nr. 2. s. 171-83.

Bibtex

@article{c755ef007da011dd81b0000ea68e967b,
title = "Brain marker protein changes after short- and long-term ethanol intoxication and withdrawal in the rat.",
abstract = "The brain marker proteins, D1, D2, and D3, localised to neuronal membranes, and mitochondrial and cytoplasmic marker proteins (MM and CM), were studied during 1-6 days (short term) intragastrically-induced severe ethanol intoxication and during 1 month (long-term) ethanol intoxication established by a liquid diet regimen. The concentrations of the same brain proteins were also measured during withdrawal from the ethanol intoxication periods. Three categories of effect were encountered: decreased concentration of brain marker proteins during severe short-term intoxication the effect being most marked for D3, possibly indicating degradation of mature synapses; increased concentration of proteins D2 and MM during withdrawal, the D2 changes possibly indicating formation of new synapses; increased concentration of D1 protein and MM during long-term intoxication. We suggest that the changes in brain marker proteins reflect dynamic changes of subcellular neuronal structures which may form a part of the basis of functional tolerance to and physical dependence upon ethanol or the reversion of these states after withdrawal of ethanol.",
author = "L Clemmesen and J{\o}rgensen, {Ole Steen} and R Hemmingsen and Barry, {D I} and Bolwig, {T G}",
note = "Keywords: Alcohol Withdrawal Delirium; Alcoholic Intoxication; Alcoholism; Animals; Brain; Cytoplasm; Male; Mitochondria; Nerve Tissue Proteins; Psychoses, Alcoholic; Rats; Rats, Inbred Strains",
year = "1987",
language = "English",
volume = "21",
pages = "171--83",
journal = "Journal of Psychiatric Research",
issn = "0022-3956",
publisher = "Pergamon Press",
number = "2",

}

RIS

TY - JOUR

T1 - Brain marker protein changes after short- and long-term ethanol intoxication and withdrawal in the rat.

AU - Clemmesen, L

AU - Jørgensen, Ole Steen

AU - Hemmingsen, R

AU - Barry, D I

AU - Bolwig, T G

N1 - Keywords: Alcohol Withdrawal Delirium; Alcoholic Intoxication; Alcoholism; Animals; Brain; Cytoplasm; Male; Mitochondria; Nerve Tissue Proteins; Psychoses, Alcoholic; Rats; Rats, Inbred Strains

PY - 1987

Y1 - 1987

N2 - The brain marker proteins, D1, D2, and D3, localised to neuronal membranes, and mitochondrial and cytoplasmic marker proteins (MM and CM), were studied during 1-6 days (short term) intragastrically-induced severe ethanol intoxication and during 1 month (long-term) ethanol intoxication established by a liquid diet regimen. The concentrations of the same brain proteins were also measured during withdrawal from the ethanol intoxication periods. Three categories of effect were encountered: decreased concentration of brain marker proteins during severe short-term intoxication the effect being most marked for D3, possibly indicating degradation of mature synapses; increased concentration of proteins D2 and MM during withdrawal, the D2 changes possibly indicating formation of new synapses; increased concentration of D1 protein and MM during long-term intoxication. We suggest that the changes in brain marker proteins reflect dynamic changes of subcellular neuronal structures which may form a part of the basis of functional tolerance to and physical dependence upon ethanol or the reversion of these states after withdrawal of ethanol.

AB - The brain marker proteins, D1, D2, and D3, localised to neuronal membranes, and mitochondrial and cytoplasmic marker proteins (MM and CM), were studied during 1-6 days (short term) intragastrically-induced severe ethanol intoxication and during 1 month (long-term) ethanol intoxication established by a liquid diet regimen. The concentrations of the same brain proteins were also measured during withdrawal from the ethanol intoxication periods. Three categories of effect were encountered: decreased concentration of brain marker proteins during severe short-term intoxication the effect being most marked for D3, possibly indicating degradation of mature synapses; increased concentration of proteins D2 and MM during withdrawal, the D2 changes possibly indicating formation of new synapses; increased concentration of D1 protein and MM during long-term intoxication. We suggest that the changes in brain marker proteins reflect dynamic changes of subcellular neuronal structures which may form a part of the basis of functional tolerance to and physical dependence upon ethanol or the reversion of these states after withdrawal of ethanol.

M3 - Journal article

C2 - 3585806

VL - 21

SP - 171

EP - 183

JO - Journal of Psychiatric Research

JF - Journal of Psychiatric Research

SN - 0022-3956

IS - 2

ER -

ID: 5941424