Blood-brain barrier permeability and electroconvulsive therapy: a systematic review
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Blood-brain barrier permeability and electroconvulsive therapy : a systematic review. / Lundsgaard, Christoffer C.; Gbyl, Krzysztof; Videbech, Poul.
I: Acta Neuropsychiatrica, 2024.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Blood-brain barrier permeability and electroconvulsive therapy
T2 - a systematic review
AU - Lundsgaard, Christoffer C.
AU - Gbyl, Krzysztof
AU - Videbech, Poul
N1 - Publisher Copyright: © The Author(s), 2023. Published by Cambridge University Press on behalf of Scandinavian College of Neuropsychopharmacology.
PY - 2024
Y1 - 2024
N2 - OBJECTIVE: The cause of cognitive side-effects after electroconvulsive therapy (ECT) is largely unknown. Alterations in the blood-brain barrier (BBB) has been considered in several recent ECT studies. We therefore found it worthwhile to perform a systematic review of the literature to examine if electrically induced seizures affect the permeability of the BBB. METHODS: PubMed/MEDLINE and Embase were searched 16 November 2022. Studies with a direct measurement of BBB permeability in animals treated with modified electroconvulsive stimulation (ECS) and in humans treated with ECT were included. Synthesis of results were narrative due to the low number of studies and differences in study designs. RESULTS: Four animal and two human (31 participants) studies were included. In animals, two studies found increased BBB permeability to some smaller molecules after modified ECS, while the two other studies found marginally increased or unchanged permeability to albumin after treatment. In contrast, the human studies did not find increased BBB permeability to smaller molecules or albumin after ECT. CONCLUSION: Animal but not human studies support increased BBB permeability to some smaller molecules after electrically induced seizures. However, this conclusion is confined by the low number of studies and the lack of studies applying state-of-the art methods. More studies using modern approaches to measuring of BBB permeability are warranted.
AB - OBJECTIVE: The cause of cognitive side-effects after electroconvulsive therapy (ECT) is largely unknown. Alterations in the blood-brain barrier (BBB) has been considered in several recent ECT studies. We therefore found it worthwhile to perform a systematic review of the literature to examine if electrically induced seizures affect the permeability of the BBB. METHODS: PubMed/MEDLINE and Embase were searched 16 November 2022. Studies with a direct measurement of BBB permeability in animals treated with modified electroconvulsive stimulation (ECS) and in humans treated with ECT were included. Synthesis of results were narrative due to the low number of studies and differences in study designs. RESULTS: Four animal and two human (31 participants) studies were included. In animals, two studies found increased BBB permeability to some smaller molecules after modified ECS, while the two other studies found marginally increased or unchanged permeability to albumin after treatment. In contrast, the human studies did not find increased BBB permeability to smaller molecules or albumin after ECT. CONCLUSION: Animal but not human studies support increased BBB permeability to some smaller molecules after electrically induced seizures. However, this conclusion is confined by the low number of studies and the lack of studies applying state-of-the art methods. More studies using modern approaches to measuring of BBB permeability are warranted.
U2 - 10.1017/neu.2023.48
DO - 10.1017/neu.2023.48
M3 - Review
C2 - 37842858
AN - SCOPUS:85175488166
JO - Acta Neuropsychiatrica
JF - Acta Neuropsychiatrica
SN - 0924-2708
ER -
ID: 386602344