Biosynthesis of endocannabinoids and their modes of action in neurodegenerative diseases

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Standard

Biosynthesis of endocannabinoids and their modes of action in neurodegenerative diseases. / van der Stelt, M.; Veldink, G.A.; Vliegenthart, J.F.G.; Hansen, H.H.; Hansen, Harald S.; Veldhuis, W.B.; Nicolay, K.; Bär, P.R.

I: Neurotoxicity Research, Bind 5, Nr. 3, 01.01.2003, s. 183-199.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

van der Stelt, M, Veldink, GA, Vliegenthart, JFG, Hansen, HH, Hansen, HS, Veldhuis, WB, Nicolay, K & Bär, PR 2003, 'Biosynthesis of endocannabinoids and their modes of action in neurodegenerative diseases', Neurotoxicity Research, bind 5, nr. 3, s. 183-199. https://doi.org/10.1007/BF03033139

APA

van der Stelt, M., Veldink, G. A., Vliegenthart, J. F. G., Hansen, H. H., Hansen, H. S., Veldhuis, W. B., Nicolay, K., & Bär, P. R. (2003). Biosynthesis of endocannabinoids and their modes of action in neurodegenerative diseases. Neurotoxicity Research, 5(3), 183-199. https://doi.org/10.1007/BF03033139

Vancouver

van der Stelt M, Veldink GA, Vliegenthart JFG, Hansen HH, Hansen HS, Veldhuis WB o.a. Biosynthesis of endocannabinoids and their modes of action in neurodegenerative diseases. Neurotoxicity Research. 2003 jan. 1;5(3):183-199. https://doi.org/10.1007/BF03033139

Author

van der Stelt, M. ; Veldink, G.A. ; Vliegenthart, J.F.G. ; Hansen, H.H. ; Hansen, Harald S. ; Veldhuis, W.B. ; Nicolay, K. ; Bär, P.R. / Biosynthesis of endocannabinoids and their modes of action in neurodegenerative diseases. I: Neurotoxicity Research. 2003 ; Bind 5, Nr. 3. s. 183-199.

Bibtex

@article{791cbcff4a2c431b9338e0b19d2d3024,
title = "Biosynthesis of endocannabinoids and their modes of action in neurodegenerative diseases",
abstract = "Endocannabinoids are thought to function as retrograde messengers, which modulate neurotransmitter release by activating presynaptic cannabinoid receptors. Anandamide and 2-arachidonoylglycerol (2-AG) are the two best studied endogenous lipids which can act as endocannabinoids. Together with the proteins responsible for their biosynthesis, inactivation and the cannabinoid receptors, these lipids constitute the endocannabinoid system. This system is proposed to be involved in various neurodegenerative diseases such as Parkinson's and Huntington's diseases as well as Multiple Sclerosis. It has been demonstrated that the endocannabinoid system can protect neurons against glutamate excitotoxicity and acute neuronal damage in both in vitro and in vivo models. In this paper we review the data concerning the involvement of the endocannabinoid system in neurodegenerative diseases in which neuronal cell death may be elicited by excitotoxicity. We focus on the biosynthesis of endocannabinoids and on their modes of action in animal models of these neurodegenerative diseases.",
author = "{van der Stelt}, M. and G.A. Veldink and J.F.G. Vliegenthart and H.H. Hansen and Hansen, {Harald S.} and W.B. Veldhuis and K. Nicolay and P.R. B{\"a}r",
year = "2003",
month = jan,
day = "1",
doi = "10.1007/BF03033139",
language = "English",
volume = "5",
pages = "183--199",
journal = "Neurotoxicity Research",
issn = "1029-8428",
publisher = "Springer",
number = "3",

}

RIS

TY - JOUR

T1 - Biosynthesis of endocannabinoids and their modes of action in neurodegenerative diseases

AU - van der Stelt, M.

AU - Veldink, G.A.

AU - Vliegenthart, J.F.G.

AU - Hansen, H.H.

AU - Hansen, Harald S.

AU - Veldhuis, W.B.

AU - Nicolay, K.

AU - Bär, P.R.

PY - 2003/1/1

Y1 - 2003/1/1

N2 - Endocannabinoids are thought to function as retrograde messengers, which modulate neurotransmitter release by activating presynaptic cannabinoid receptors. Anandamide and 2-arachidonoylglycerol (2-AG) are the two best studied endogenous lipids which can act as endocannabinoids. Together with the proteins responsible for their biosynthesis, inactivation and the cannabinoid receptors, these lipids constitute the endocannabinoid system. This system is proposed to be involved in various neurodegenerative diseases such as Parkinson's and Huntington's diseases as well as Multiple Sclerosis. It has been demonstrated that the endocannabinoid system can protect neurons against glutamate excitotoxicity and acute neuronal damage in both in vitro and in vivo models. In this paper we review the data concerning the involvement of the endocannabinoid system in neurodegenerative diseases in which neuronal cell death may be elicited by excitotoxicity. We focus on the biosynthesis of endocannabinoids and on their modes of action in animal models of these neurodegenerative diseases.

AB - Endocannabinoids are thought to function as retrograde messengers, which modulate neurotransmitter release by activating presynaptic cannabinoid receptors. Anandamide and 2-arachidonoylglycerol (2-AG) are the two best studied endogenous lipids which can act as endocannabinoids. Together with the proteins responsible for their biosynthesis, inactivation and the cannabinoid receptors, these lipids constitute the endocannabinoid system. This system is proposed to be involved in various neurodegenerative diseases such as Parkinson's and Huntington's diseases as well as Multiple Sclerosis. It has been demonstrated that the endocannabinoid system can protect neurons against glutamate excitotoxicity and acute neuronal damage in both in vitro and in vivo models. In this paper we review the data concerning the involvement of the endocannabinoid system in neurodegenerative diseases in which neuronal cell death may be elicited by excitotoxicity. We focus on the biosynthesis of endocannabinoids and on their modes of action in animal models of these neurodegenerative diseases.

UR - http://www.scopus.com/inward/record.url?scp=0037771394&partnerID=8YFLogxK

U2 - 10.1007/BF03033139

DO - 10.1007/BF03033139

M3 - Journal article

AN - SCOPUS:0037771394

VL - 5

SP - 183

EP - 199

JO - Neurotoxicity Research

JF - Neurotoxicity Research

SN - 1029-8428

IS - 3

ER -

ID: 45561768